Hodgkin Lymphoma as a Secondary Neoplasm During Therapy for Chronic Myeloid Leukaemia: Case Report and Review of the Literature

• Main Authors: Paczkowska E, Janowski M, Karpińska K, Ryłów M, Zdziarska B, Poncyljusz W, Machaliński B
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-04-01
• Series: OncoTargets and Therapy
• Subjects: chronic myeloid leukemia; hodgkin lymphoma; dasatinib; lymphadenopathy; tyrosine kinase inhibitors
• Online Access: https://www.dovepress.com/hodgkin-lymphoma-as-a-secondary-neoplasm-during-therapy-for-chronic-my-peer-reviewed-article-OTT
• ISSN: 1178-6930

Edyta Paczkowska,1,2 Michał Janowski,2 Katarzyna Karpińska,3 Małgorzata Ryłów,2 Barbara Zdziarska,2 Wojciech Poncyljusz,4 Bogusław Machaliński1 1Department of General Pathology, Pomeranian Medical University, Szczecin, Poland; 2Department of Hematology with Bone Marrow Transplantation Unit, University Hospital No. 1 of Pomeranian Medical University, Szczecin, Poland; 3Department of Pathomorphology, Pomeranian Medical University, Szczecin, Poland; 4Department of Diagnostic Imaging and Interventional Radiology, Pomeranian Medical University, Szczecin, PolandCorrespondence: Edyta PaczkowskaDepartment of General Pathology, Pomeranian Medical University, Al. Powstańców Wlkp. 72, Szczecin, 70-111, PolandEmail [e-mail]: Incidences of chronic myeloid leukaemia (CML) after treatment of Hodgkin lymphoma (HL) are well described. Here, we report a case of secondary HL in a patient with CML treated with dasatinib as a third-line treatment.Patient Information: A 64-year-old male was diagnosed with CML and initially treated with imatinib and then with nilotinib due to resistance. Finally, the patient experienced cardiovascular complications, and dasatinib was introduced. After 19 months of treatment, the patient experienced enlargement of lymph nodes that formed packs on the neck.Interventions: Based on histopathological examination of the lymph nodes, a diagnosis of classical Hodgkin lymphoma – mixed cellularity was established. The patient was successfully treated with 4 cycles of AVD (adriamycin, vinblastine, dacarbazine) chemotherapy.Outcomes: Complete metabolic remission of Hodgkin lymphoma is currently sustained, and the molecular response to dasatinib at a reduced dose of 50 mg daily corresponds with a deep molecular response.Conclusion: In this report, we demonstrate the efficacy and safety of the combination of dasatinib and AVD regimens in coexisting CML and HL. This case report emphasizes the importance of insightful evaluation and differential diagnosis in cases of lymphadenopathy during CML treatment.Keywords: chronic myeloid leukemia, Hodgkin lymphoma, dasatinib, lymphadenopathy, tyrosine kinase inhibitors