Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland

Various types of genetic variation contribute to the etiology of intellectual disability (ID). Here, the authors study a cohort of ID patients enriched for mild ID from Finland, to investigate contributions of rare and common variants associated with ID of different levels of severity.

Bibliographic Details
Main Authors:	Mitja I. Kurki, Elmo Saarentaus, Olli Pietiläinen, Padhraig Gormley, Dennis Lal, Sini Kerminen, Minna Torniainen-Holm, Eija Hämäläinen, Elisa Rahikkala, Riikka Keski-Filppula, Merja Rauhala, Satu Korpi-Heikkilä, Jonna Komulainen–Ebrahim, Heli Helander, Päivi Vieira, Minna Männikkö, Markku Peltonen, Aki S. Havulinna, Veikko Salomaa, Matti Pirinen, Jaana Suvisaari, Jukka S. Moilanen, Jarmo Körkkö, Outi Kuismin, Mark J. Daly, Aarno Palotie
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-08262-y

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spelling	doaj-ab9e0271d0224acca582195c7d5d71d82021-05-11T12:15:49ZengNature Publishing GroupNature Communications2041-17232019-01-0110111510.1038/s41467-018-08262-yContribution of rare and common variants to intellectual disability in a sub-isolate of Northern FinlandMitja I. Kurki0Elmo Saarentaus1Olli Pietiläinen2Padhraig Gormley3Dennis Lal4Sini Kerminen5Minna Torniainen-Holm6Eija Hämäläinen7Elisa Rahikkala8Riikka Keski-Filppula9Merja Rauhala10Satu Korpi-Heikkilä11Jonna Komulainen–Ebrahim12Heli Helander13Päivi Vieira14Minna Männikkö15Markku Peltonen16Aki S. Havulinna17Veikko Salomaa18Matti Pirinen19Jaana Suvisaari20Jukka S. Moilanen21Jarmo Körkkö22Outi Kuismin23Mark J. Daly24Aarno Palotie25Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, BostonInstitute for Molecular Medicine Finland (FIMM), University of HelsinkiThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and HarvardPsychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, BostonPsychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, BostonInstitute for Molecular Medicine Finland (FIMM), University of HelsinkiInstitute for Molecular Medicine Finland (FIMM), University of HelsinkiInstitute for Molecular Medicine Finland (FIMM), University of HelsinkiPEDEGO Research Unit, University of OuluPEDEGO Research Unit, University of OuluNorthern Ostrobothnia Hospital District, Center for Intellectual Disability CareNorthern Ostrobothnia Hospital District, Center for Intellectual Disability CareDepartment of Children and Adolescents, Oulu University Hospital, Medical Research Center Oulu, University of OuluDepartment of Children and Adolescents, Oulu University Hospital, Medical Research Center Oulu, University of OuluDepartment of Children and Adolescents, Oulu University Hospital, Medical Research Center Oulu, University of OuluCenter for Life Course Health Research, Faculty of Medicine, University of OuluNational Institute for Health and WelfareInstitute for Molecular Medicine Finland (FIMM), University of HelsinkiNational Institute for Health and WelfareInstitute for Molecular Medicine Finland (FIMM), University of HelsinkiNational Institute for Health and WelfarePEDEGO Research Unit, University of OuluNorthern Ostrobothnia Hospital District, Center for Intellectual Disability CareInstitute for Molecular Medicine Finland (FIMM), University of HelsinkiPsychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, BostonPsychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, BostonVarious types of genetic variation contribute to the etiology of intellectual disability (ID). Here, the authors study a cohort of ID patients enriched for mild ID from Finland, to investigate contributions of rare and common variants associated with ID of different levels of severity.https://doi.org/10.1038/s41467-018-08262-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mitja I. Kurki Elmo Saarentaus Olli Pietiläinen Padhraig Gormley Dennis Lal Sini Kerminen Minna Torniainen-Holm Eija Hämäläinen Elisa Rahikkala Riikka Keski-Filppula Merja Rauhala Satu Korpi-Heikkilä Jonna Komulainen–Ebrahim Heli Helander Päivi Vieira Minna Männikkö Markku Peltonen Aki S. Havulinna Veikko Salomaa Matti Pirinen Jaana Suvisaari Jukka S. Moilanen Jarmo Körkkö Outi Kuismin Mark J. Daly Aarno Palotie
spellingShingle	Mitja I. Kurki Elmo Saarentaus Olli Pietiläinen Padhraig Gormley Dennis Lal Sini Kerminen Minna Torniainen-Holm Eija Hämäläinen Elisa Rahikkala Riikka Keski-Filppula Merja Rauhala Satu Korpi-Heikkilä Jonna Komulainen–Ebrahim Heli Helander Päivi Vieira Minna Männikkö Markku Peltonen Aki S. Havulinna Veikko Salomaa Matti Pirinen Jaana Suvisaari Jukka S. Moilanen Jarmo Körkkö Outi Kuismin Mark J. Daly Aarno Palotie Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland Nature Communications
author_facet	Mitja I. Kurki Elmo Saarentaus Olli Pietiläinen Padhraig Gormley Dennis Lal Sini Kerminen Minna Torniainen-Holm Eija Hämäläinen Elisa Rahikkala Riikka Keski-Filppula Merja Rauhala Satu Korpi-Heikkilä Jonna Komulainen–Ebrahim Heli Helander Päivi Vieira Minna Männikkö Markku Peltonen Aki S. Havulinna Veikko Salomaa Matti Pirinen Jaana Suvisaari Jukka S. Moilanen Jarmo Körkkö Outi Kuismin Mark J. Daly Aarno Palotie
author_sort	Mitja I. Kurki
title	Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland
title_short	Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland
title_full	Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland
title_fullStr	Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland
title_full_unstemmed	Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland
title_sort	contribution of rare and common variants to intellectual disability in a sub-isolate of northern finland
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-01-01
description	Various types of genetic variation contribute to the etiology of intellectual disability (ID). Here, the authors study a cohort of ID patients enriched for mild ID from Finland, to investigate contributions of rare and common variants associated with ID of different levels of severity.
url	https://doi.org/10.1038/s41467-018-08262-y
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Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland

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