Improved Stability of Emulsions in Preparation of Uniform Small-Sized Konjac Glucomanna (KGM) Microspheres with Epoxy-Based Polymer Membrane by Premix Membrane Emulsification
Uniform small-sized (<10 μm) Konjac glucomanna (KGM) microspheres have great application prospects in bio-separation, drug delivery and controlled release. Premix membrane emulsification is an effective method to prepare uniform small-sized KGM microspheres. However, since KGM solution bears...
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doaj-aba7659ab11440ebad5eaf04c70aad422020-11-24T22:21:00ZengMDPI AGPolymers2073-43602016-02-01835310.3390/polym8030053polym8030053Improved Stability of Emulsions in Preparation of Uniform Small-Sized Konjac Glucomanna (KGM) Microspheres with Epoxy-Based Polymer Membrane by Premix Membrane EmulsificationYace Mi0Juan Li1Weiqing Zhou2Rongyue Zhang3Guanghui Ma4Zhiguo Su5National Key Laboratory of Biochemical Engineering , Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, ChinaNational Key Laboratory of Biochemical Engineering , Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, ChinaNational Key Laboratory of Biochemical Engineering , Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, ChinaNational Key Laboratory of Biochemical Engineering , Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, ChinaNational Key Laboratory of Biochemical Engineering , Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, ChinaNational Key Laboratory of Biochemical Engineering , Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, ChinaUniform small-sized (<10 μm) Konjac glucomanna (KGM) microspheres have great application prospects in bio-separation, drug delivery and controlled release. Premix membrane emulsification is an effective method to prepare uniform small-sized KGM microspheres. However, since KGM solution bears strong alkalinity, it requires the membrane to have a hydrophobic surface resistant to alkali. In this study, uniform small-sized KGM microspheres were prepared with epoxy-based polymer membrane (EP) we developed by premix membrane emulsification. It was found that emulsion coalescence and flocculation occurred frequently due to the high interface energy and sedimentation velocity of KGM emulsions. Emulsion stability had a significant influence on the uniformity and dispersity of the final KGM microspheres. To improve the stability of the emulsions, the effects of the concentration of the emulsifier, the viscosity of the KGM solution, the oil phase composition and the feeding method of epoxy chloropropane (EC) on the preparation results were studied. Under optimal preparation conditions (emulsifier 5 wt % PO-5s, KGM III (145.6 mPa·s), weight ratio of liquid paraffin (LP) to petroleum ether (PE) 11:1), uniform and stable KGM emulsions (d = 7.47 μm, CV = 15.35%) were obtained and crosslinked without emulsion-instable phenomena.http://www.mdpi.com/2073-4360/8/3/53uniform small-sized KGM microspherespremix membrane emulsificationEpoxy-based polymer membrane (EP)alkaline condition |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yace Mi Juan Li Weiqing Zhou Rongyue Zhang Guanghui Ma Zhiguo Su |
spellingShingle |
Yace Mi Juan Li Weiqing Zhou Rongyue Zhang Guanghui Ma Zhiguo Su Improved Stability of Emulsions in Preparation of Uniform Small-Sized Konjac Glucomanna (KGM) Microspheres with Epoxy-Based Polymer Membrane by Premix Membrane Emulsification Polymers uniform small-sized KGM microspheres premix membrane emulsification Epoxy-based polymer membrane (EP) alkaline condition |
author_facet |
Yace Mi Juan Li Weiqing Zhou Rongyue Zhang Guanghui Ma Zhiguo Su |
author_sort |
Yace Mi |
title |
Improved Stability of Emulsions in Preparation of Uniform Small-Sized Konjac Glucomanna (KGM) Microspheres with Epoxy-Based Polymer Membrane by Premix Membrane Emulsification |
title_short |
Improved Stability of Emulsions in Preparation of Uniform Small-Sized Konjac Glucomanna (KGM) Microspheres with Epoxy-Based Polymer Membrane by Premix Membrane Emulsification |
title_full |
Improved Stability of Emulsions in Preparation of Uniform Small-Sized Konjac Glucomanna (KGM) Microspheres with Epoxy-Based Polymer Membrane by Premix Membrane Emulsification |
title_fullStr |
Improved Stability of Emulsions in Preparation of Uniform Small-Sized Konjac Glucomanna (KGM) Microspheres with Epoxy-Based Polymer Membrane by Premix Membrane Emulsification |
title_full_unstemmed |
Improved Stability of Emulsions in Preparation of Uniform Small-Sized Konjac Glucomanna (KGM) Microspheres with Epoxy-Based Polymer Membrane by Premix Membrane Emulsification |
title_sort |
improved stability of emulsions in preparation of uniform small-sized konjac glucomanna (kgm) microspheres with epoxy-based polymer membrane by premix membrane emulsification |
publisher |
MDPI AG |
series |
Polymers |
issn |
2073-4360 |
publishDate |
2016-02-01 |
description |
Uniform small-sized (<10 μm) Konjac glucomanna (KGM) microspheres have great application prospects in bio-separation, drug delivery and controlled release. Premix membrane emulsification is an effective method to prepare uniform small-sized KGM microspheres. However, since KGM solution bears strong alkalinity, it requires the membrane to have a hydrophobic surface resistant to alkali. In this study, uniform small-sized KGM microspheres were prepared with epoxy-based polymer membrane (EP) we developed by premix membrane emulsification. It was found that emulsion coalescence and flocculation occurred frequently due to the high interface energy and sedimentation velocity of KGM emulsions. Emulsion stability had a significant influence on the uniformity and dispersity of the final KGM microspheres. To improve the stability of the emulsions, the effects of the concentration of the emulsifier, the viscosity of the KGM solution, the oil phase composition and the feeding method of epoxy chloropropane (EC) on the preparation results were studied. Under optimal preparation conditions (emulsifier 5 wt % PO-5s, KGM III (145.6 mPa·s), weight ratio of liquid paraffin (LP) to petroleum ether (PE) 11:1), uniform and stable KGM emulsions (d = 7.47 μm, CV = 15.35%) were obtained and crosslinked without emulsion-instable phenomena. |
topic |
uniform small-sized KGM microspheres premix membrane emulsification Epoxy-based polymer membrane (EP) alkaline condition |
url |
http://www.mdpi.com/2073-4360/8/3/53 |
work_keys_str_mv |
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