Recovery from Age-Related Infertility under Environmental Light-Dark Cycles Adjusted to the Intrinsic Circadian Period
Female reproductive function changes during aging with the estrous cycle becoming more irregular during the transition to menopause. We found that intermittent shifts of the light-dark cycle disrupted regularity of estrous cycles in middle-aged female mice, whose estrous cycles were regular under un...
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doaj-abaf19e37ef94fb6b30c80c24eb6d9cb2020-11-24T21:47:27ZengElsevierCell Reports2211-12472015-09-011291407141310.1016/j.celrep.2015.07.049Recovery from Age-Related Infertility under Environmental Light-Dark Cycles Adjusted to the Intrinsic Circadian PeriodNana N. Takasu0Takahiro J. Nakamura1Isao T. Tokuda2Takeshi Todo3Gene D. Block4Wataru Nakamura5Laboratory of Oral Chronobiology, Graduate School of Dentistry, Osaka University, Suita, Osaka 565-0871, JapanDepartment of Life Sciences, School of Agriculture, Meiji University, Kawasaki, Kanagawa 214-8571, JapanDepartment of Mechanical Engineering, Ritsumeikan University, Kusatsu, Shiga 525-8577, JapanDepartment of Radiation Biology and Medical Genetics, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, JapanDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90024-1759, USALaboratory of Oral Chronobiology, Graduate School of Dentistry, Osaka University, Suita, Osaka 565-0871, JapanFemale reproductive function changes during aging with the estrous cycle becoming more irregular during the transition to menopause. We found that intermittent shifts of the light-dark cycle disrupted regularity of estrous cycles in middle-aged female mice, whose estrous cycles were regular under unperturbed 24-hr light-dark cycles. Although female mice deficient in Cry1 or Cry2, the core components of the molecular circadian clock, exhibited regular estrous cycles during youth, they showed accelerated senescence characterized by irregular and unstable estrous cycles and resultant infertility in middle age. Notably, tuning the period length of the environmental light-dark cycles closely to the endogenous one inherent in the Cry-deficient females restored the regularity of the estrous cycles and, consequently, improved fertility in middle age. These results suggest that reproductive potential can be strongly influenced by age-related changes in the circadian system and normal reproductive functioning can be rescued by the manipulation of environmental timing signals.http://www.sciencedirect.com/science/article/pii/S221112471500827X |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nana N. Takasu Takahiro J. Nakamura Isao T. Tokuda Takeshi Todo Gene D. Block Wataru Nakamura |
spellingShingle |
Nana N. Takasu Takahiro J. Nakamura Isao T. Tokuda Takeshi Todo Gene D. Block Wataru Nakamura Recovery from Age-Related Infertility under Environmental Light-Dark Cycles Adjusted to the Intrinsic Circadian Period Cell Reports |
author_facet |
Nana N. Takasu Takahiro J. Nakamura Isao T. Tokuda Takeshi Todo Gene D. Block Wataru Nakamura |
author_sort |
Nana N. Takasu |
title |
Recovery from Age-Related Infertility under Environmental Light-Dark Cycles Adjusted to the Intrinsic Circadian Period |
title_short |
Recovery from Age-Related Infertility under Environmental Light-Dark Cycles Adjusted to the Intrinsic Circadian Period |
title_full |
Recovery from Age-Related Infertility under Environmental Light-Dark Cycles Adjusted to the Intrinsic Circadian Period |
title_fullStr |
Recovery from Age-Related Infertility under Environmental Light-Dark Cycles Adjusted to the Intrinsic Circadian Period |
title_full_unstemmed |
Recovery from Age-Related Infertility under Environmental Light-Dark Cycles Adjusted to the Intrinsic Circadian Period |
title_sort |
recovery from age-related infertility under environmental light-dark cycles adjusted to the intrinsic circadian period |
publisher |
Elsevier |
series |
Cell Reports |
issn |
2211-1247 |
publishDate |
2015-09-01 |
description |
Female reproductive function changes during aging with the estrous cycle becoming more irregular during the transition to menopause. We found that intermittent shifts of the light-dark cycle disrupted regularity of estrous cycles in middle-aged female mice, whose estrous cycles were regular under unperturbed 24-hr light-dark cycles. Although female mice deficient in Cry1 or Cry2, the core components of the molecular circadian clock, exhibited regular estrous cycles during youth, they showed accelerated senescence characterized by irregular and unstable estrous cycles and resultant infertility in middle age. Notably, tuning the period length of the environmental light-dark cycles closely to the endogenous one inherent in the Cry-deficient females restored the regularity of the estrous cycles and, consequently, improved fertility in middle age. These results suggest that reproductive potential can be strongly influenced by age-related changes in the circadian system and normal reproductive functioning can be rescued by the manipulation of environmental timing signals. |
url |
http://www.sciencedirect.com/science/article/pii/S221112471500827X |
work_keys_str_mv |
AT nanantakasu recoveryfromagerelatedinfertilityunderenvironmentallightdarkcyclesadjustedtotheintrinsiccircadianperiod AT takahirojnakamura recoveryfromagerelatedinfertilityunderenvironmentallightdarkcyclesadjustedtotheintrinsiccircadianperiod AT isaottokuda recoveryfromagerelatedinfertilityunderenvironmentallightdarkcyclesadjustedtotheintrinsiccircadianperiod AT takeshitodo recoveryfromagerelatedinfertilityunderenvironmentallightdarkcyclesadjustedtotheintrinsiccircadianperiod AT genedblock recoveryfromagerelatedinfertilityunderenvironmentallightdarkcyclesadjustedtotheintrinsiccircadianperiod AT watarunakamura recoveryfromagerelatedinfertilityunderenvironmentallightdarkcyclesadjustedtotheintrinsiccircadianperiod |
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