Krüppel-Like Factor 15 Modulates CXCL1/CXCR2 Signaling-Mediated Inflammatory Response Contributing to Angiotensin II-Induced Cardiac Remodeling

Krüppel-Like Factor 15 Modulates CXCL1/CXCR2 Signaling-Mediated Inflammatory Response Contributing to Angiotensin II-Induced Cardiac Remodeling

Inflammation is involved in cardiac remodeling. In response to pathological stimuli, activated cardiac fibroblasts (CFs) secreting inflammatory cytokines and chemokines play an important role in monocyte/macrophage recruitment. However, the precise mechanism of CF-mediated inflammatory response in h...

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Bibliographic Details
Main Authors: Shun He, Yuanyuan Lu, Yuetong Guo, Shijin Li, Xiao Lu, Shuai Shao, Handan Zhou, Ruiqi Wang, Jiguang Wang, Pingjin Gao, Xiaodong Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hypertension
renin-angiotensin system
transcription factor
cardiac remodeling
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.644954/full

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