Antisense Oligonucleotide Against Clusterin Regulates Human Hepatocellular Carcinoma Invasion Through Transcriptional Regulation of Matrix Metalloproteinase-2 and E-Cadherin

Antisense Oligonucleotide Against Clusterin Regulates Human Hepatocellular Carcinoma Invasion Through Transcriptional Regulation of Matrix Metalloproteinase-2 and E-Cadherin

Secreted clusterin (sCLU) has been shown to be overexpressed in metastatic hepatocellular carcinoma (HCC) tissue, and its overexpression in HCC cells increases cell migration and the formation of liver metastatic tumor nodules <em>in vivo</em>. In this study, we tested th...

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Bibliographic Details
Main Authors: Bomin Yan, Jun Liang, Xuelong Jiao, Kejun Zhang, Yan Wang, Dong Chen
Format: Article
Language:English
Published: MDPI AG 2012-08-01
Series:International Journal of Molecular Sciences
Subjects:
hepatocellular carcinoma
metastasis
clusterin
Online Access:http://www.mdpi.com/1422-0067/13/8/10594

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