A Case of Kawasaki Disease with Coronary Aneurysm Responding to the 4th IVIG Treatment
Kawasaki disease is an acute febrile illness that usually occurs in children younger than 5 years of age. The use of intravenous immunoglobulin (IVIG) within the first 10 days of illness has been shown to reduce the incidence of coronary artery aneurysms significantly. The relative roles of repeated...
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Online Access: | http://dx.doi.org/10.1155/2014/821812 |
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doaj-abc84702d16d4e989e1b9c8a8d2a0e872020-11-24T22:20:53ZengHindawi LimitedCase Reports in Cardiology2090-64042090-64122014-01-01201410.1155/2014/821812821812A Case of Kawasaki Disease with Coronary Aneurysm Responding to the 4th IVIG TreatmentJu Young Kim0Hyun Jung Kim1Department of Pediatrics, Eulji University Hospital, Eulji University School of Medicine, 1306, Dunsan-dong, Seo-gu, Daejeon 302-799, Republic of KoreaDepartment of Pediatrics, Eulji University Hospital, Eulji University School of Medicine, 1306, Dunsan-dong, Seo-gu, Daejeon 302-799, Republic of KoreaKawasaki disease is an acute febrile illness that usually occurs in children younger than 5 years of age. The use of intravenous immunoglobulin (IVIG) within the first 10 days of illness has been shown to reduce the incidence of coronary artery aneurysms significantly. The relative roles of repeated doses of intravenous immunoglobulin (IVIG) are controversial in refractory Kawasaki disease (KD). Most experts recommend the second retreatment with IVIG, 2 g/kg in refractory KD. However, the dose-response effect of the third or fourth IVIG was uncertain. Although there have been a significant number of reports on new therapeutic options for refractory KD, such as steroid, infliximab, methotrexate, and other immunosuppressants, their effectiveness in reducing the prevalence of coronary artery aneurysms was unproven. We present here KD patient with small coronary artery aneurysm who is resistant to the third IVIG and steroid pulse therapy but showed improvement immediately after the infusion of the 4th IVIG on fever day 18.http://dx.doi.org/10.1155/2014/821812 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ju Young Kim Hyun Jung Kim |
spellingShingle |
Ju Young Kim Hyun Jung Kim A Case of Kawasaki Disease with Coronary Aneurysm Responding to the 4th IVIG Treatment Case Reports in Cardiology |
author_facet |
Ju Young Kim Hyun Jung Kim |
author_sort |
Ju Young Kim |
title |
A Case of Kawasaki Disease with Coronary Aneurysm Responding to the 4th IVIG Treatment |
title_short |
A Case of Kawasaki Disease with Coronary Aneurysm Responding to the 4th IVIG Treatment |
title_full |
A Case of Kawasaki Disease with Coronary Aneurysm Responding to the 4th IVIG Treatment |
title_fullStr |
A Case of Kawasaki Disease with Coronary Aneurysm Responding to the 4th IVIG Treatment |
title_full_unstemmed |
A Case of Kawasaki Disease with Coronary Aneurysm Responding to the 4th IVIG Treatment |
title_sort |
case of kawasaki disease with coronary aneurysm responding to the 4th ivig treatment |
publisher |
Hindawi Limited |
series |
Case Reports in Cardiology |
issn |
2090-6404 2090-6412 |
publishDate |
2014-01-01 |
description |
Kawasaki disease is an acute febrile illness that usually occurs in children younger than 5 years of age. The use of intravenous immunoglobulin (IVIG) within the first 10 days of illness has been shown to reduce the incidence of coronary artery aneurysms significantly. The relative roles of repeated doses of intravenous immunoglobulin (IVIG) are controversial in refractory Kawasaki disease (KD). Most experts recommend the second retreatment with IVIG, 2 g/kg in refractory KD. However, the dose-response effect of the third or fourth IVIG was uncertain. Although there have been a significant number of reports on new therapeutic options for refractory KD, such as steroid, infliximab, methotrexate, and other immunosuppressants, their effectiveness in reducing the prevalence of coronary artery aneurysms was unproven. We present here KD patient with small coronary artery aneurysm who is resistant to the third IVIG and steroid pulse therapy but showed improvement immediately after the infusion of the 4th IVIG on fever day 18. |
url |
http://dx.doi.org/10.1155/2014/821812 |
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