THE ACTIVITY OF 4-AMINOQUINOLINE AGAINST PLASMODIUM FALCIPARUM IN SOUTHERN IRAN
The resistance of Plasmodium falciparum to 4-amioquinolines has been confirmed in parts of South America such as Venezuela, Colombia, Brazil and Panama since 1961. During 1968-1970, 147 P. falciparum cases in the Kazeroon and Bandar Abbas areas were tested against 4-aminoquinolines, bases on 25 mg...
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Tehran University of Medical Sciences
1973-06-01
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doaj-abcc6c26f0584c048081a5c52d9f49df2020-12-02T18:51:56ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60931973-06-01221472THE ACTIVITY OF 4-AMINOQUINOLINE AGAINST PLASMODIUM FALCIPARUM IN SOUTHERN IRAN AV. Manouchehri0 M.Motabar1 A. Al Mohammad2 The resistance of Plasmodium falciparum to 4-amioquinolines has been confirmed in parts of South America such as Venezuela, Colombia, Brazil and Panama since 1961. During 1968-1970, 147 P. falciparum cases in the Kazeroon and Bandar Abbas areas were tested against 4-aminoquinolines, bases on 25 mg Resochin /kg of body weight over a period of 3 days. Twenty–foure, 48 , 72 and 96 hours after drug administration, the parasitemia rate was 80.5, 24.8, 1.65 and 0 per cennt, respectively . Blood samples taken from the subjects showed no asexual parasitemia for up to 28 days. Tests were carried out by the two – stage and single – stage methods (WHO, 1965 , 1967).The subjects were observed daily for 7 days after drug administration and then weekly for up to 4 weeks. Urine samples were taken and examined for chloroqine by days, one subject showed parasitemia. He was re-treated with 4-aminoquinolines and his blood was cleared of asexual parasites after the administration of 1500 mg of chloroqine.These studies showed that the local strain of P. falciparum in this area was susceptible to chloroqine.https://ijph.tums.ac.ir/index.php/ijph/article/view/14834 – aminoquinolinesAsexual parasites |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
AV. Manouchehri M.Motabar A. Al Mohammad |
spellingShingle |
AV. Manouchehri M.Motabar A. Al Mohammad THE ACTIVITY OF 4-AMINOQUINOLINE AGAINST PLASMODIUM FALCIPARUM IN SOUTHERN IRAN Iranian Journal of Public Health 4 – aminoquinolines Asexual parasites |
author_facet |
AV. Manouchehri M.Motabar A. Al Mohammad |
author_sort |
AV. Manouchehri |
title |
THE ACTIVITY OF 4-AMINOQUINOLINE AGAINST PLASMODIUM FALCIPARUM IN SOUTHERN IRAN |
title_short |
THE ACTIVITY OF 4-AMINOQUINOLINE AGAINST PLASMODIUM FALCIPARUM IN SOUTHERN IRAN |
title_full |
THE ACTIVITY OF 4-AMINOQUINOLINE AGAINST PLASMODIUM FALCIPARUM IN SOUTHERN IRAN |
title_fullStr |
THE ACTIVITY OF 4-AMINOQUINOLINE AGAINST PLASMODIUM FALCIPARUM IN SOUTHERN IRAN |
title_full_unstemmed |
THE ACTIVITY OF 4-AMINOQUINOLINE AGAINST PLASMODIUM FALCIPARUM IN SOUTHERN IRAN |
title_sort |
activity of 4-aminoquinoline against plasmodium falciparum in southern iran |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Public Health |
issn |
2251-6085 2251-6093 |
publishDate |
1973-06-01 |
description |
The resistance of Plasmodium falciparum to 4-amioquinolines has been confirmed in parts of South America such as Venezuela, Colombia, Brazil and Panama since 1961. During 1968-1970, 147 P. falciparum cases in the Kazeroon and Bandar Abbas areas were tested against 4-aminoquinolines, bases on 25 mg Resochin /kg of body weight over a period of 3 days. Twenty–foure, 48 , 72 and 96 hours after drug administration, the parasitemia rate was 80.5, 24.8, 1.65 and 0 per cennt, respectively . Blood samples taken from the subjects showed no asexual parasitemia for up to 28 days. Tests were carried out by the two – stage and single – stage methods (WHO, 1965 , 1967).The subjects were observed daily for 7 days after drug administration and then weekly for up to 4 weeks. Urine samples were taken and examined for chloroqine by days, one subject showed parasitemia. He was re-treated with 4-aminoquinolines and his blood was cleared of asexual parasites after the administration of 1500 mg of chloroqine.These studies showed that the local strain of P. falciparum in this area was susceptible to chloroqine. |
topic |
4 – aminoquinolines Asexual parasites |
url |
https://ijph.tums.ac.ir/index.php/ijph/article/view/1483 |
work_keys_str_mv |
AT avmanouchehri theactivityof4aminoquinolineagainstplasmodiumfalciparuminsoutherniran AT mmotabar theactivityof4aminoquinolineagainstplasmodiumfalciparuminsoutherniran AT aalmohammad theactivityof4aminoquinolineagainstplasmodiumfalciparuminsoutherniran AT avmanouchehri activityof4aminoquinolineagainstplasmodiumfalciparuminsoutherniran AT mmotabar activityof4aminoquinolineagainstplasmodiumfalciparuminsoutherniran AT aalmohammad activityof4aminoquinolineagainstplasmodiumfalciparuminsoutherniran |
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