Dynamic changes in serum steroid hormone during the first trimester of pregnancy between infertile women conceiving with and without hormone replacement therapy
Objective: Recent advances in cancer treatment and reproductive medicine have made the post-treatment quality of life an important concern for cancer survivors. We aimed to evaluate the safety of sex hormone (estradiol and progesterone) replacement therapy (HRT) in women who conceived by assisted re...
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doaj-abd33e8157f545308e51a4c439438cb02021-10-07T04:26:26ZengElsevierHeliyon2405-84402021-10-01710e08100Dynamic changes in serum steroid hormone during the first trimester of pregnancy between infertile women conceiving with and without hormone replacement therapyAyumu Ito0Yukiko Katagiri1Yusuke Fukuda2Mineto Morita3Department of Obstetrics and Gynecology, Toho University Graduate School of Medicine, 5-21-16 Omorinishi Ota-ku, Tokyo, Japan; Department of Obstetrics and Gynecology, Faculty of Medicine, Toho University, 5-21-16 Omorinishi Ota-ku, Tokyo, Japan; Reproduction Center, Toho University Omori Medical Center, 6-11-1 Omorinishi Ota-ku, Tokyo, JapanDepartment of Obstetrics and Gynecology, Toho University Graduate School of Medicine, 5-21-16 Omorinishi Ota-ku, Tokyo, Japan; Department of Obstetrics and Gynecology, Faculty of Medicine, Toho University, 5-21-16 Omorinishi Ota-ku, Tokyo, Japan; Reproduction Center, Toho University Omori Medical Center, 6-11-1 Omorinishi Ota-ku, Tokyo, Japan; Corresponding author.Department of Obstetrics and Gynecology, Faculty of Medicine, Toho University, 5-21-16 Omorinishi Ota-ku, Tokyo, Japan; Reproduction Center, Toho University Omori Medical Center, 6-11-1 Omorinishi Ota-ku, Tokyo, JapanDepartment of Obstetrics and Gynecology, Toho University Graduate School of Medicine, 5-21-16 Omorinishi Ota-ku, Tokyo, Japan; Department of Obstetrics and Gynecology, Faculty of Medicine, Toho University, 5-21-16 Omorinishi Ota-ku, Tokyo, JapanObjective: Recent advances in cancer treatment and reproductive medicine have made the post-treatment quality of life an important concern for cancer survivors. We aimed to evaluate the safety of sex hormone (estradiol and progesterone) replacement therapy (HRT) in women who conceived by assisted reproductive technology (ART) with hormone receptor-positive breast cancer. Methods: We measured serum E2 and P4 levels at 4–10 weeks of gestation in women who conceived naturally or after timed intercourse or intrauterine insemination for infertility without HRT for luteal support (non-HR group; n = 135). We conducted a retrospective comparison of the values from the non-HR group with those of women who conceived by ART with HRT for infertility (HR group; n = 75). Results: Serum E2 levels were significantly higher in the non-HR group than in the HR group at 5, 6, and 8 weeks of gestation. Similarly, serum P4 levels were significantly higher in the non-HR group than in the HR group at 4, 5, and 6 weeks of gestation. Conclusions: This study suggests that in cancer reproductive medicine for hormone-dependent breast cancer survivors, HRT administered during the first trimester of a pregnancy after primary disease treatment may not increase the sex hormone levels to levels above those seen in spontaneous pregnancy.http://www.sciencedirect.com/science/article/pii/S2405844021022039Breast cancerHormone receptor-positiveCancer survivorOncofertilityFertility preservationAdolescent and young adult |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ayumu Ito Yukiko Katagiri Yusuke Fukuda Mineto Morita |
spellingShingle |
Ayumu Ito Yukiko Katagiri Yusuke Fukuda Mineto Morita Dynamic changes in serum steroid hormone during the first trimester of pregnancy between infertile women conceiving with and without hormone replacement therapy Heliyon Breast cancer Hormone receptor-positive Cancer survivor Oncofertility Fertility preservation Adolescent and young adult |
author_facet |
Ayumu Ito Yukiko Katagiri Yusuke Fukuda Mineto Morita |
author_sort |
Ayumu Ito |
title |
Dynamic changes in serum steroid hormone during the first trimester of pregnancy between infertile women conceiving with and without hormone replacement therapy |
title_short |
Dynamic changes in serum steroid hormone during the first trimester of pregnancy between infertile women conceiving with and without hormone replacement therapy |
title_full |
Dynamic changes in serum steroid hormone during the first trimester of pregnancy between infertile women conceiving with and without hormone replacement therapy |
title_fullStr |
Dynamic changes in serum steroid hormone during the first trimester of pregnancy between infertile women conceiving with and without hormone replacement therapy |
title_full_unstemmed |
Dynamic changes in serum steroid hormone during the first trimester of pregnancy between infertile women conceiving with and without hormone replacement therapy |
title_sort |
dynamic changes in serum steroid hormone during the first trimester of pregnancy between infertile women conceiving with and without hormone replacement therapy |
publisher |
Elsevier |
series |
Heliyon |
issn |
2405-8440 |
publishDate |
2021-10-01 |
description |
Objective: Recent advances in cancer treatment and reproductive medicine have made the post-treatment quality of life an important concern for cancer survivors. We aimed to evaluate the safety of sex hormone (estradiol and progesterone) replacement therapy (HRT) in women who conceived by assisted reproductive technology (ART) with hormone receptor-positive breast cancer. Methods: We measured serum E2 and P4 levels at 4–10 weeks of gestation in women who conceived naturally or after timed intercourse or intrauterine insemination for infertility without HRT for luteal support (non-HR group; n = 135). We conducted a retrospective comparison of the values from the non-HR group with those of women who conceived by ART with HRT for infertility (HR group; n = 75). Results: Serum E2 levels were significantly higher in the non-HR group than in the HR group at 5, 6, and 8 weeks of gestation. Similarly, serum P4 levels were significantly higher in the non-HR group than in the HR group at 4, 5, and 6 weeks of gestation. Conclusions: This study suggests that in cancer reproductive medicine for hormone-dependent breast cancer survivors, HRT administered during the first trimester of a pregnancy after primary disease treatment may not increase the sex hormone levels to levels above those seen in spontaneous pregnancy. |
topic |
Breast cancer Hormone receptor-positive Cancer survivor Oncofertility Fertility preservation Adolescent and young adult |
url |
http://www.sciencedirect.com/science/article/pii/S2405844021022039 |
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