Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus
Nitric oxide (NO) is a major neurotransmitter associated with motor control in basal ganglia. Movement disorders, as essential tremor and Parkinson’s disease, are more prevalent on aged individuals. We investigated the effects of aging on neuronal density and diameter/area of nitrergic neurons in sa...
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Academia Brasileira de Neurologia (ABNEURO)
2015-09-01
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doaj-abd3b5e431ff4a45b5ae1a36aa5e2dd22020-11-24T23:26:38ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272015-09-0173977978310.1590/0004-282X20150097S0004-282X2015000900779Effects of aging on nitrergic neurons in human striatum and subthalamic nucleusBruno Lopes dos Santos-LobatoElaine Aparecida Del-BelJosé Eymard Homem PittellaVitor TumasNitric oxide (NO) is a major neurotransmitter associated with motor control in basal ganglia. Movement disorders, as essential tremor and Parkinson’s disease, are more prevalent on aged individuals. We investigated the effects of aging on neuronal density and diameter/area of nitrergic neurons in samples of striatum (caudate and putamen) and subthalamic nucleus of 20 human brains from normal subjects, stained by histochemistry for NADPH-diaphorase and immunohistochemistry for neuronal NO synthase. Our data showed aging does not modify the neuronal density and size of nitrergic neurons in striatum and subthalamic nucleus. These findings suggest a lack of association between aging and morphologic changes on nitrergic neurons.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000900779&lng=en&tlng=enóxido nítriconúcleos da baseestriadonúcleo subtalâmicoenvelhecimento |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bruno Lopes dos Santos-Lobato Elaine Aparecida Del-Bel José Eymard Homem Pittella Vitor Tumas |
spellingShingle |
Bruno Lopes dos Santos-Lobato Elaine Aparecida Del-Bel José Eymard Homem Pittella Vitor Tumas Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus Arquivos de Neuro-Psiquiatria óxido nítrico núcleos da base estriado núcleo subtalâmico envelhecimento |
author_facet |
Bruno Lopes dos Santos-Lobato Elaine Aparecida Del-Bel José Eymard Homem Pittella Vitor Tumas |
author_sort |
Bruno Lopes dos Santos-Lobato |
title |
Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus |
title_short |
Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus |
title_full |
Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus |
title_fullStr |
Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus |
title_full_unstemmed |
Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus |
title_sort |
effects of aging on nitrergic neurons in human striatum and subthalamic nucleus |
publisher |
Academia Brasileira de Neurologia (ABNEURO) |
series |
Arquivos de Neuro-Psiquiatria |
issn |
1678-4227 |
publishDate |
2015-09-01 |
description |
Nitric oxide (NO) is a major neurotransmitter associated with motor control in basal ganglia. Movement disorders, as essential tremor and Parkinson’s disease, are more prevalent on aged individuals. We investigated the effects of aging on neuronal density and diameter/area of nitrergic neurons in samples of striatum (caudate and putamen) and subthalamic nucleus of 20 human brains from normal subjects, stained by histochemistry for NADPH-diaphorase and immunohistochemistry for neuronal NO synthase. Our data showed aging does not modify the neuronal density and size of nitrergic neurons in striatum and subthalamic nucleus. These findings suggest a lack of association between aging and morphologic changes on nitrergic neurons. |
topic |
óxido nítrico núcleos da base estriado núcleo subtalâmico envelhecimento |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000900779&lng=en&tlng=en |
work_keys_str_mv |
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