Disease Affects Bdnf Expression in Synaptic and Extrasynaptic Regions of Skeletal Muscle of Three SBMA Mouse Models

Disease Affects Bdnf Expression in Synaptic and Extrasynaptic Regions of Skeletal Muscle of Three SBMA Mouse Models

Spinal bulbar muscular atrophy (SBMA) is a slowly progressive, androgen-dependent neuromuscular disease in men that is characterized by both muscle and synaptic dysfunction. Because gene expression in muscle is heterogeneous, with synaptic myonuclei expressing genes that regulate synaptic function a...

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Bibliographic Details
Main Authors: Katherine Halievski, Samir R. Nath, Masahisa Katsuno, Hiroaki Adachi, Gen Sobue, S. Marc Breedlove, Andrew P. Lieberman, Cynthia L. Jordan
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
SBMA
synaptic
extrasynaptic
gene expression
neurotrophic factors
muscle
Online Access:http://www.mdpi.com/1422-0067/20/6/1314

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