Bronchodilator Response in Patients with Persistent Allergic Asthma Could Not Predict Airway Hyperresponsiveness
<p/> <p>Anticholinergics, or specific antimuscarinic agents, by inhibition of muscarinic receptors cause bronchodilatation, which might correlate with activation of these receptors by the muscarinic agonist methacholine. The aim of this study was to determine whether a positive bronchodi...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2007-12-01
|
Series: | Allergy, Asthma & Clinical Immunology |
Subjects: | |
Online Access: | http://www.aacijournal.com/content/3/4/123 |
id |
doaj-abd8eb2fb812439a8d2ae454f123fd5f |
---|---|
record_format |
Article |
spelling |
doaj-abd8eb2fb812439a8d2ae454f123fd5f2020-11-24T21:28:04ZengBMCAllergy, Asthma & Clinical Immunology1710-14841710-14922007-12-013412312710.1186/1710-1492-3-4-123Bronchodilator Response in Patients with Persistent Allergic Asthma Could Not Predict Airway HyperresponsivenessPetanjek Bojana BGrle Sanja PPelicarić DubravkaVranković Dubravka<p/> <p>Anticholinergics, or specific antimuscarinic agents, by inhibition of muscarinic receptors cause bronchodilatation, which might correlate with activation of these receptors by the muscarinic agonist methacholine. The aim of this study was to determine whether a positive bronchodilator response to the anticholinergic ipratropium bromide could predict airway hyperresponsiveness in patients with persistent allergic asthma. The study comprised 40 patients with mild and moderate persistent allergic asthma. Diagnosis was established by clinical and functional follow-up (skin-prick test, spirometry, bronchodilator tests with salbutamol and ipratropium bromide, and methacholine challenge testing). The bronchodilator response was positive to both bronchodilator drugs in all patients. After salbutamol inhalation, forced expiratory volume in 1 second (FEV<sub>1</sub>) increased by 18.39 ± 6.18%, <it>p </it>< .01, whereas after ipratropium bromide, FEV<sub>1 </sub>increased by 19.14 ± 6.74%, <it>p </it>< .01. The mean value of FEV<sub>1 </sub>decreased by 25.75 ± 5.16%, <it>p </it>< .01 after methacholine (PC<sub>20 </sub>FEV<sub>1 </sub>[provocative concentration of methacholine that results in a 20% fall in FEV<sub>1</sub>] from 0.026 to 1.914 mg/mL). Using linear regression, between methacholine challenge testing and bronchodilator response to salbutamol, a positive, weak, and stastistically significant correlation for FEV<sub>1 </sub>was found (<it>p </it>< .05). Correlations between methacholine challenge testing and the bronchodilator response to ipratropium bromide were positive and weak but not statistically significant. The positive bronchodilator response to ipratropium bromide could not predict airway hyperresponsiveness.</p> http://www.aacijournal.com/content/3/4/123airway hyperresponsivenessallergic asthmabronchodilator responseipratropium bromidemethacholine challenge testingsalbutamol |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Petanjek Bojana B Grle Sanja P Pelicarić Dubravka Vranković Dubravka |
spellingShingle |
Petanjek Bojana B Grle Sanja P Pelicarić Dubravka Vranković Dubravka Bronchodilator Response in Patients with Persistent Allergic Asthma Could Not Predict Airway Hyperresponsiveness Allergy, Asthma & Clinical Immunology airway hyperresponsiveness allergic asthma bronchodilator response ipratropium bromide methacholine challenge testing salbutamol |
author_facet |
Petanjek Bojana B Grle Sanja P Pelicarić Dubravka Vranković Dubravka |
author_sort |
Petanjek Bojana B |
title |
Bronchodilator Response in Patients with Persistent Allergic Asthma Could Not Predict Airway Hyperresponsiveness |
title_short |
Bronchodilator Response in Patients with Persistent Allergic Asthma Could Not Predict Airway Hyperresponsiveness |
title_full |
Bronchodilator Response in Patients with Persistent Allergic Asthma Could Not Predict Airway Hyperresponsiveness |
title_fullStr |
Bronchodilator Response in Patients with Persistent Allergic Asthma Could Not Predict Airway Hyperresponsiveness |
title_full_unstemmed |
Bronchodilator Response in Patients with Persistent Allergic Asthma Could Not Predict Airway Hyperresponsiveness |
title_sort |
bronchodilator response in patients with persistent allergic asthma could not predict airway hyperresponsiveness |
publisher |
BMC |
series |
Allergy, Asthma & Clinical Immunology |
issn |
1710-1484 1710-1492 |
publishDate |
2007-12-01 |
description |
<p/> <p>Anticholinergics, or specific antimuscarinic agents, by inhibition of muscarinic receptors cause bronchodilatation, which might correlate with activation of these receptors by the muscarinic agonist methacholine. The aim of this study was to determine whether a positive bronchodilator response to the anticholinergic ipratropium bromide could predict airway hyperresponsiveness in patients with persistent allergic asthma. The study comprised 40 patients with mild and moderate persistent allergic asthma. Diagnosis was established by clinical and functional follow-up (skin-prick test, spirometry, bronchodilator tests with salbutamol and ipratropium bromide, and methacholine challenge testing). The bronchodilator response was positive to both bronchodilator drugs in all patients. After salbutamol inhalation, forced expiratory volume in 1 second (FEV<sub>1</sub>) increased by 18.39 ± 6.18%, <it>p </it>< .01, whereas after ipratropium bromide, FEV<sub>1 </sub>increased by 19.14 ± 6.74%, <it>p </it>< .01. The mean value of FEV<sub>1 </sub>decreased by 25.75 ± 5.16%, <it>p </it>< .01 after methacholine (PC<sub>20 </sub>FEV<sub>1 </sub>[provocative concentration of methacholine that results in a 20% fall in FEV<sub>1</sub>] from 0.026 to 1.914 mg/mL). Using linear regression, between methacholine challenge testing and bronchodilator response to salbutamol, a positive, weak, and stastistically significant correlation for FEV<sub>1 </sub>was found (<it>p </it>< .05). Correlations between methacholine challenge testing and the bronchodilator response to ipratropium bromide were positive and weak but not statistically significant. The positive bronchodilator response to ipratropium bromide could not predict airway hyperresponsiveness.</p> |
topic |
airway hyperresponsiveness allergic asthma bronchodilator response ipratropium bromide methacholine challenge testing salbutamol |
url |
http://www.aacijournal.com/content/3/4/123 |
work_keys_str_mv |
AT petanjekbojanab bronchodilatorresponseinpatientswithpersistentallergicasthmacouldnotpredictairwayhyperresponsiveness AT grlesanjap bronchodilatorresponseinpatientswithpersistentallergicasthmacouldnotpredictairwayhyperresponsiveness AT pelicaricdubravka bronchodilatorresponseinpatientswithpersistentallergicasthmacouldnotpredictairwayhyperresponsiveness AT vrankovicdubravka bronchodilatorresponseinpatientswithpersistentallergicasthmacouldnotpredictairwayhyperresponsiveness |
_version_ |
1725971785456812032 |