Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation
Pyruvate kinase M2 (PKM2) activity is regulated by the availability of metabolic intermediates for nucleotide and amino acid synthesis. Here, the authors show that PKM2 citrullination by PADI1 and PADI3 lowers its sensitivity to metabolic inhibitors leading to increased glycolysis and reduced cancer...
Main Authors: | Sébastien Coassolo, Guillaume Davidson, Luc Negroni, Giovanni Gambi, Sylvain Daujat, Christophe Romier, Irwin Davidson |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-03-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-21960-4 |
Similar Items
-
Potential role for PADI-mediated histone citrullination in preimplantation development
by: Kan Rui, et al.
Published: (2012-06-01) -
Pyruvate kinase & glycolysis in potato
by: Robinson, Andrew James Cave
Published: (1990) -
Peptidyl Arginine Deiminase 2 (PADI2)-Mediated Arginine Citrullination Modulates Transcription in Cancer
by: Miguel Beato, et al.
Published: (2020-02-01) -
Anti-PADI4 antibody suppresses breast cancer by repressing the citrullinated fibronectin in the tumor microenvironment
by: Cai, D., et al.
Published: (2022) -
BALAI BESAR PENELITIAN TANAMAN PADI (BB PADI) SUKAMANDI
by: Dian Indra Dewi, et al.
Published: (2012-11-01)