Synthesis and characterization of silver nanoparticle-decorated cobalt nanocomposites (Co@AgNPs) and their density-dependent antibacterial activity
Magnetic cores loaded with metallic nanoparticles can be promising nano-carriers for successful drug delivery at infectious sites. We report fabrication, characteristic analysis and in vitro antibacterial performance of nanocomposites comprising cobalt cores (Co-cores) functionalized with a varied c...
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doaj-abe3455d30b24c5ca0337247f9dc53642020-11-25T03:06:28ZengThe Royal SocietyRoyal Society Open Science2054-57032019-05-016510.1098/rsos.182135182135Synthesis and characterization of silver nanoparticle-decorated cobalt nanocomposites (Co@AgNPs) and their density-dependent antibacterial activityZakia KanwalMuhammad Akram RazaSaira RiazSaher ManzoorAsima TayyebImran SajidShahzad NaseemMagnetic cores loaded with metallic nanoparticles can be promising nano-carriers for successful drug delivery at infectious sites. We report fabrication, characteristic analysis and in vitro antibacterial performance of nanocomposites comprising cobalt cores (Co-cores) functionalized with a varied concentration of silver nanoparticles (AgNPs). A two-step polyol process synchronized with the transmetalation reduction method was used. Co-cores were synthesized with cobalt acetate, and decoration of AgNPs was carried out with silver acetate. The density of AgNPs was varied by changing the amount of silver content as 0.01, 0.1 and 0.2 g in the synthesis solution. Both AgNPs and Co-cores were spherical having a size range of 30–80 nm and 200 nm to more than 1 µm, respectively, as determined by scanning electron microscopy. The metallic nature and face-centred cubic crystalline phase of prepared nanocomposites were confirmed by X-ray diffraction. Biocompatibility analysis confirmed high cell viability of MCF7 at low concentrations of tested particles. The antibacterial performance of nanocomposites (Co@AgNPs) against Escherichia coli and Bacillus subtilis was found to be AgNPs density-dependent, and nanocomposites with the highest AgNPs density exhibited the maximum bactericidal efficacy. We therefore propose that Co@AgNPs as effective drug containers for various biomedical applications.https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.182135nanocompositesmagnetic coressilver nanoparticlescytotoxicityantibacterial activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zakia Kanwal Muhammad Akram Raza Saira Riaz Saher Manzoor Asima Tayyeb Imran Sajid Shahzad Naseem |
spellingShingle |
Zakia Kanwal Muhammad Akram Raza Saira Riaz Saher Manzoor Asima Tayyeb Imran Sajid Shahzad Naseem Synthesis and characterization of silver nanoparticle-decorated cobalt nanocomposites (Co@AgNPs) and their density-dependent antibacterial activity Royal Society Open Science nanocomposites magnetic cores silver nanoparticles cytotoxicity antibacterial activity |
author_facet |
Zakia Kanwal Muhammad Akram Raza Saira Riaz Saher Manzoor Asima Tayyeb Imran Sajid Shahzad Naseem |
author_sort |
Zakia Kanwal |
title |
Synthesis and characterization of silver nanoparticle-decorated cobalt nanocomposites (Co@AgNPs) and their density-dependent antibacterial activity |
title_short |
Synthesis and characterization of silver nanoparticle-decorated cobalt nanocomposites (Co@AgNPs) and their density-dependent antibacterial activity |
title_full |
Synthesis and characterization of silver nanoparticle-decorated cobalt nanocomposites (Co@AgNPs) and their density-dependent antibacterial activity |
title_fullStr |
Synthesis and characterization of silver nanoparticle-decorated cobalt nanocomposites (Co@AgNPs) and their density-dependent antibacterial activity |
title_full_unstemmed |
Synthesis and characterization of silver nanoparticle-decorated cobalt nanocomposites (Co@AgNPs) and their density-dependent antibacterial activity |
title_sort |
synthesis and characterization of silver nanoparticle-decorated cobalt nanocomposites (co@agnps) and their density-dependent antibacterial activity |
publisher |
The Royal Society |
series |
Royal Society Open Science |
issn |
2054-5703 |
publishDate |
2019-05-01 |
description |
Magnetic cores loaded with metallic nanoparticles can be promising nano-carriers for successful drug delivery at infectious sites. We report fabrication, characteristic analysis and in vitro antibacterial performance of nanocomposites comprising cobalt cores (Co-cores) functionalized with a varied concentration of silver nanoparticles (AgNPs). A two-step polyol process synchronized with the transmetalation reduction method was used. Co-cores were synthesized with cobalt acetate, and decoration of AgNPs was carried out with silver acetate. The density of AgNPs was varied by changing the amount of silver content as 0.01, 0.1 and 0.2 g in the synthesis solution. Both AgNPs and Co-cores were spherical having a size range of 30–80 nm and 200 nm to more than 1 µm, respectively, as determined by scanning electron microscopy. The metallic nature and face-centred cubic crystalline phase of prepared nanocomposites were confirmed by X-ray diffraction. Biocompatibility analysis confirmed high cell viability of MCF7 at low concentrations of tested particles. The antibacterial performance of nanocomposites (Co@AgNPs) against Escherichia coli and Bacillus subtilis was found to be AgNPs density-dependent, and nanocomposites with the highest AgNPs density exhibited the maximum bactericidal efficacy. We therefore propose that Co@AgNPs as effective drug containers for various biomedical applications. |
topic |
nanocomposites magnetic cores silver nanoparticles cytotoxicity antibacterial activity |
url |
https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.182135 |
work_keys_str_mv |
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1724673904974233600 |