Protocol for a four parallel-arm, single-blind, cluster-randomised trial to assess the effectiveness of three types of dual active ingredient treated nets compared to pyrethroid-only long-lasting insecticidal nets to prevent malaria transmitted by pyrethroid insecticide-resistant vector mosquitoes in Tanzania
Introduction The massive scale-up of long-lasting insecticidal nets (LLINs) has led to major reductions in malaria burden in many sub-Saharan African countries. This progress is threatened by widespread insecticide resistance among malaria vectors. This cluster-randomised controlled trial (c-RCT) co...
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doaj-abea04bddf8c4119b1fc74df82eff6e32021-07-02T13:03:42ZengBMJ Publishing GroupBMJ Open2044-60552021-03-0111310.1136/bmjopen-2020-046664Protocol for a four parallel-arm, single-blind, cluster-randomised trial to assess the effectiveness of three types of dual active ingredient treated nets compared to pyrethroid-only long-lasting insecticidal nets to prevent malaria transmitted by pyrethroid insecticide-resistant vector mosquitoes in TanzaniaMonica Taljaard0Mark Rowland1Jacklin F. Mosha2Manisha A. Kulkarni3Louisa A. Messenger4Nancy Matowo5Eliud Lukole6Charles Thickstun7Alphaxard Manjurano8Franklin W. Mosha9Immo Kleinschmidt10Natacha Protopopoff11Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, CanadaDisease Control, London School of Hygiene & Tropical Medicine, London, UKParasitology, National Institute for Medical Research Mwanza Research Centre, Mwanza, United Republic of TanzaniaEpidemiology & Public Health, University of Ottawa Faculty of Medicine, Ottawa, Ontario, CanadaDisease Control, London School of Hygiene & Tropical Medicine, London, UKDisease Control, London School of Hygiene & Tropical Medicine, London, UKParasitology, National Institute for Medical Research Mwanza Research Centre, Mwanza, United Republic of TanzaniaEpidemiology & Public Health, University of Ottawa Faculty of Medicine, Ottawa, Ontario, CanadaParasitology, National Institute for Medical Research Mwanza Research Centre, Mwanza, United Republic of TanzaniaParasitology, Kilimanjaro Christian Medical University College, Moshi, United Republic of TanzaniaInfectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UKDisease Control, London School of Hygiene & Tropical Medicine, London, UKIntroduction The massive scale-up of long-lasting insecticidal nets (LLINs) has led to major reductions in malaria burden in many sub-Saharan African countries. This progress is threatened by widespread insecticide resistance among malaria vectors. This cluster-randomised controlled trial (c-RCT) compares three of the most promising dual active ingredients LLINs (dual-AI LLINs), which incorporate mixtures of insecticides or insecticide synergists to standard LLINs in an area of pyrethroid insecticide resistance.Methods A four-arm, single-blinded, c-RCT will evaluate the effectiveness of three types of dual-AI LLINs (1) Royal Guard, combining two insecticides, pyriproxyfen and the pyrethroid alpha-cypermethrin; (2) Interceptor G2, combining chlorfenapyr and alpha-cypermethrin; (3) Olyset Plus, an LLIN combining a synergist, piperonyl butoxide and the pyrethroid permethrin, compared with; (4) Interceptor LN, a standard LLIN containing the pyrethroid alpha-cypermethrin as the sole AI. The primary outcomes are malaria infection prevalence in children aged 6 months–14 years and entomological inoculation rate (EIR), as a standard measure of malaria transmission at 24 months postintervention and cost-effectiveness.Ethics and dissemination Ethical approval was received from the institutional review boards of the Tanzanian National Institute for Medical Research, Kilimanjaro Christian Medical University College, London School of Hygiene and Tropical Medicine, and University of Ottawa. Study findings will be actively disseminated via reports and presentations to stakeholders, local community leaders, and relevant national and international policy makers as well as through conferences, and peer-reviewed publications.Trial registration number NCT03554616.https://bmjopen.bmj.com/content/11/3/e046664.full |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Monica Taljaard Mark Rowland Jacklin F. Mosha Manisha A. Kulkarni Louisa A. Messenger Nancy Matowo Eliud Lukole Charles Thickstun Alphaxard Manjurano Franklin W. Mosha Immo Kleinschmidt Natacha Protopopoff |
spellingShingle |
Monica Taljaard Mark Rowland Jacklin F. Mosha Manisha A. Kulkarni Louisa A. Messenger Nancy Matowo Eliud Lukole Charles Thickstun Alphaxard Manjurano Franklin W. Mosha Immo Kleinschmidt Natacha Protopopoff Protocol for a four parallel-arm, single-blind, cluster-randomised trial to assess the effectiveness of three types of dual active ingredient treated nets compared to pyrethroid-only long-lasting insecticidal nets to prevent malaria transmitted by pyrethroid insecticide-resistant vector mosquitoes in Tanzania BMJ Open |
author_facet |
Monica Taljaard Mark Rowland Jacklin F. Mosha Manisha A. Kulkarni Louisa A. Messenger Nancy Matowo Eliud Lukole Charles Thickstun Alphaxard Manjurano Franklin W. Mosha Immo Kleinschmidt Natacha Protopopoff |
author_sort |
Monica Taljaard |
title |
Protocol for a four parallel-arm, single-blind, cluster-randomised trial to assess the effectiveness of three types of dual active ingredient treated nets compared to pyrethroid-only long-lasting insecticidal nets to prevent malaria transmitted by pyrethroid insecticide-resistant vector mosquitoes in Tanzania |
title_short |
Protocol for a four parallel-arm, single-blind, cluster-randomised trial to assess the effectiveness of three types of dual active ingredient treated nets compared to pyrethroid-only long-lasting insecticidal nets to prevent malaria transmitted by pyrethroid insecticide-resistant vector mosquitoes in Tanzania |
title_full |
Protocol for a four parallel-arm, single-blind, cluster-randomised trial to assess the effectiveness of three types of dual active ingredient treated nets compared to pyrethroid-only long-lasting insecticidal nets to prevent malaria transmitted by pyrethroid insecticide-resistant vector mosquitoes in Tanzania |
title_fullStr |
Protocol for a four parallel-arm, single-blind, cluster-randomised trial to assess the effectiveness of three types of dual active ingredient treated nets compared to pyrethroid-only long-lasting insecticidal nets to prevent malaria transmitted by pyrethroid insecticide-resistant vector mosquitoes in Tanzania |
title_full_unstemmed |
Protocol for a four parallel-arm, single-blind, cluster-randomised trial to assess the effectiveness of three types of dual active ingredient treated nets compared to pyrethroid-only long-lasting insecticidal nets to prevent malaria transmitted by pyrethroid insecticide-resistant vector mosquitoes in Tanzania |
title_sort |
protocol for a four parallel-arm, single-blind, cluster-randomised trial to assess the effectiveness of three types of dual active ingredient treated nets compared to pyrethroid-only long-lasting insecticidal nets to prevent malaria transmitted by pyrethroid insecticide-resistant vector mosquitoes in tanzania |
publisher |
BMJ Publishing Group |
series |
BMJ Open |
issn |
2044-6055 |
publishDate |
2021-03-01 |
description |
Introduction The massive scale-up of long-lasting insecticidal nets (LLINs) has led to major reductions in malaria burden in many sub-Saharan African countries. This progress is threatened by widespread insecticide resistance among malaria vectors. This cluster-randomised controlled trial (c-RCT) compares three of the most promising dual active ingredients LLINs (dual-AI LLINs), which incorporate mixtures of insecticides or insecticide synergists to standard LLINs in an area of pyrethroid insecticide resistance.Methods A four-arm, single-blinded, c-RCT will evaluate the effectiveness of three types of dual-AI LLINs (1) Royal Guard, combining two insecticides, pyriproxyfen and the pyrethroid alpha-cypermethrin; (2) Interceptor G2, combining chlorfenapyr and alpha-cypermethrin; (3) Olyset Plus, an LLIN combining a synergist, piperonyl butoxide and the pyrethroid permethrin, compared with; (4) Interceptor LN, a standard LLIN containing the pyrethroid alpha-cypermethrin as the sole AI. The primary outcomes are malaria infection prevalence in children aged 6 months–14 years and entomological inoculation rate (EIR), as a standard measure of malaria transmission at 24 months postintervention and cost-effectiveness.Ethics and dissemination Ethical approval was received from the institutional review boards of the Tanzanian National Institute for Medical Research, Kilimanjaro Christian Medical University College, London School of Hygiene and Tropical Medicine, and University of Ottawa. Study findings will be actively disseminated via reports and presentations to stakeholders, local community leaders, and relevant national and international policy makers as well as through conferences, and peer-reviewed publications.Trial registration number NCT03554616. |
url |
https://bmjopen.bmj.com/content/11/3/e046664.full |
work_keys_str_mv |
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