The Selection of Oral Antidiabetic Drugs in Type 2 Diabetes Mellitus Patients with High Risk for Cardiovascular Events
Type 2 diabetes mellitus (DMT2) patients are associated with an increased risk of cardiovascular events. Prior to the era of cardio-vascular trial outcome (CVOT) evidence on the efficacy of old oral diabetes (OAD) drugs such as metformin, sulfonylurea, thiazolidindion, glinid, and alpha glucosidase...
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Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital
2020-12-01
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doaj-abeb864f9afb434db783e6f0dbad34fa2021-01-01T11:14:24ZindDepartment of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalJurnal Penyakit Dalam Indonesia2406-89692549-06212020-12-0174240248http://dx.doi.org/10.7454/jpdi.v7i4.292The Selection of Oral Antidiabetic Drugs in Type 2 Diabetes Mellitus Patients with High Risk for Cardiovascular EventsDerlin J. Leander0Dicky L Tahapary1Fakultas Kedokteran Universitas Indonesia, Jakarta Indonesia Divisi Metabolik Endokrin, Departemen Ilmu Penyakit Dalam, RSUPN Dr. Cipto Mangunkusumo, Fakultas Kedokteran Universitas Indonesia Type 2 diabetes mellitus (DMT2) patients are associated with an increased risk of cardiovascular events. Prior to the era of cardio-vascular trial outcome (CVOT) evidence on the efficacy of old oral diabetes (OAD) drugs such as metformin, sulfonylurea, thiazolidindion, glinid, and alpha glucosidase inhibitors in reducing the risk of cardiovascular events was very limited. Since 2008, all OADs must have CVOT data. DPP-4 inhibitors are neutral against the risk of cardiovascular events while SGLT-2 inhibitors are reported to significantly reduce the risk of cardiovascular events. This finding even helped to change the DMT2 management guidelines issued by American Diabetes Association (ADA-EASD) in late 2018. However, SGLT-2 inhibitor applications in Indonesia are likely to be constrained in terms of costs. When compared with an intensive multifactorial approach that seeks to reduce blood glucose, lipids, blood pressure, weight, and aspirin; it turns out that this multifactorial approach is associated with a lower risk of higher cardiovascular events and lower costs. In the JKN era, where quality control and cost control are needed, it seems that the multifactorial approach will still be the main choice in reducing cardiovascular events in people with T2DM in Indonesia.http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/292/258cardiovascular eventsdiabetes mellitus type 2multifactorial approachoral antidiabetic drugs |
collection |
DOAJ |
language |
Indonesian |
format |
Article |
sources |
DOAJ |
author |
Derlin J. Leander Dicky L Tahapary |
spellingShingle |
Derlin J. Leander Dicky L Tahapary The Selection of Oral Antidiabetic Drugs in Type 2 Diabetes Mellitus Patients with High Risk for Cardiovascular Events Jurnal Penyakit Dalam Indonesia cardiovascular events diabetes mellitus type 2 multifactorial approach oral antidiabetic drugs |
author_facet |
Derlin J. Leander Dicky L Tahapary |
author_sort |
Derlin J. Leander |
title |
The Selection of Oral Antidiabetic Drugs in Type 2 Diabetes Mellitus Patients with High Risk for Cardiovascular Events |
title_short |
The Selection of Oral Antidiabetic Drugs in Type 2 Diabetes Mellitus Patients with High Risk for Cardiovascular Events |
title_full |
The Selection of Oral Antidiabetic Drugs in Type 2 Diabetes Mellitus Patients with High Risk for Cardiovascular Events |
title_fullStr |
The Selection of Oral Antidiabetic Drugs in Type 2 Diabetes Mellitus Patients with High Risk for Cardiovascular Events |
title_full_unstemmed |
The Selection of Oral Antidiabetic Drugs in Type 2 Diabetes Mellitus Patients with High Risk for Cardiovascular Events |
title_sort |
selection of oral antidiabetic drugs in type 2 diabetes mellitus patients with high risk for cardiovascular events |
publisher |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital |
series |
Jurnal Penyakit Dalam Indonesia |
issn |
2406-8969 2549-0621 |
publishDate |
2020-12-01 |
description |
Type 2 diabetes mellitus (DMT2) patients are associated with an increased risk of cardiovascular events. Prior to the era of cardio-vascular trial outcome (CVOT) evidence on the efficacy of old oral diabetes (OAD) drugs such as metformin, sulfonylurea, thiazolidindion, glinid, and alpha glucosidase inhibitors in reducing the risk of cardiovascular events was very limited. Since 2008, all OADs must have CVOT data. DPP-4 inhibitors are neutral against the risk of cardiovascular events while SGLT-2 inhibitors are reported to significantly reduce the risk of cardiovascular events. This finding even helped to change the DMT2 management guidelines issued by American Diabetes Association (ADA-EASD) in late 2018. However, SGLT-2 inhibitor applications in Indonesia are likely to be constrained in terms of costs. When compared with an intensive multifactorial approach that seeks to reduce blood glucose, lipids, blood pressure, weight, and aspirin; it turns out that this multifactorial approach is associated with a lower risk of higher cardiovascular events and lower costs. In the JKN era, where quality control and cost control are needed, it seems that the multifactorial approach will still be the main choice in reducing cardiovascular events in people with T2DM in Indonesia. |
topic |
cardiovascular events diabetes mellitus type 2 multifactorial approach oral antidiabetic drugs |
url |
http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/292/258 |
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