A cdk1 gradient guides surface contraction waves in oocytes

Surface contraction waves (SCWs) are prominent shape changes coupled to cell cycle transitions in oocytes. Here the authors show that SCWs are patterned by the spatiotemporal integration of two conserved modules, cdk1-cyclinB for cell cycle regulation and RhoA/Rok/NMYII for actomyosin contractility.

Bibliographic Details
Main Authors:	Johanna Bischof, Christoph A. Brand, Kálmán Somogyi, Imre Májer, Sarah Thome, Masashi Mori, Ulrich S. Schwarz, Péter Lénárt
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-00979-6

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spelling	doaj-abec266d937c4acfa74253dfd390e3c92021-05-11T07:17:41ZengNature Publishing GroupNature Communications2041-17232017-10-018111010.1038/s41467-017-00979-6A cdk1 gradient guides surface contraction waves in oocytesJohanna Bischof0Christoph A. Brand1Kálmán Somogyi2Imre Májer3Sarah Thome4Masashi Mori5Ulrich S. Schwarz6Péter Lénárt7Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL)Institute for Theoretical Physics and BioQuant, Heidelberg UniversityCell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL)Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL)Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL)Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL)Institute for Theoretical Physics and BioQuant, Heidelberg UniversityCell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL)Surface contraction waves (SCWs) are prominent shape changes coupled to cell cycle transitions in oocytes. Here the authors show that SCWs are patterned by the spatiotemporal integration of two conserved modules, cdk1-cyclinB for cell cycle regulation and RhoA/Rok/NMYII for actomyosin contractility.https://doi.org/10.1038/s41467-017-00979-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Johanna Bischof Christoph A. Brand Kálmán Somogyi Imre Májer Sarah Thome Masashi Mori Ulrich S. Schwarz Péter Lénárt
spellingShingle	Johanna Bischof Christoph A. Brand Kálmán Somogyi Imre Májer Sarah Thome Masashi Mori Ulrich S. Schwarz Péter Lénárt A cdk1 gradient guides surface contraction waves in oocytes Nature Communications
author_facet	Johanna Bischof Christoph A. Brand Kálmán Somogyi Imre Májer Sarah Thome Masashi Mori Ulrich S. Schwarz Péter Lénárt
author_sort	Johanna Bischof
title	A cdk1 gradient guides surface contraction waves in oocytes
title_short	A cdk1 gradient guides surface contraction waves in oocytes
title_full	A cdk1 gradient guides surface contraction waves in oocytes
title_fullStr	A cdk1 gradient guides surface contraction waves in oocytes
title_full_unstemmed	A cdk1 gradient guides surface contraction waves in oocytes
title_sort	cdk1 gradient guides surface contraction waves in oocytes
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-10-01
description	Surface contraction waves (SCWs) are prominent shape changes coupled to cell cycle transitions in oocytes. Here the authors show that SCWs are patterned by the spatiotemporal integration of two conserved modules, cdk1-cyclinB for cell cycle regulation and RhoA/Rok/NMYII for actomyosin contractility.
url	https://doi.org/10.1038/s41467-017-00979-6
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A cdk1 gradient guides surface contraction waves in oocytes

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