Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia
Lipocalin 2 (LCN2) has been recently identified as an endogenous regulator of appetite. Here, using pancreatic cancer as a model of cachexia, the authors demonstrate that LCN2 is a critical mediator of cancer-associated anorexia and may be therapeutically targeted to improve patient outcomes.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22361-3 |
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Article |
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doaj-abf8c7f4da7a45d4af0d1631fd5836592021-04-11T11:11:48ZengNature Publishing GroupNature Communications2041-17232021-04-0112111510.1038/s41467-021-22361-3Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexiaBrennan Olson0Xinxia Zhu1Mason A. Norgard2Peter R. Levasseur3John T. Butler4Abigail Buenafe5Kevin G. Burfeind6Katherine A. Michaelis7Katherine R. Pelz8Heike Mendez9Jared Edwards10Stephanie M. Krasnow11Aaron J. Grossberg12Daniel L. Marks13Papé Family Pediatric Research Institute, Oregon Health & Science UniversityPapé Family Pediatric Research Institute, Oregon Health & Science UniversityPapé Family Pediatric Research Institute, Oregon Health & Science UniversityPapé Family Pediatric Research Institute, Oregon Health & Science UniversityPapé Family Pediatric Research Institute, Oregon Health & Science UniversityPapé Family Pediatric Research Institute, Oregon Health & Science UniversityPapé Family Pediatric Research Institute, Oregon Health & Science UniversityPapé Family Pediatric Research Institute, Oregon Health & Science UniversityBrenden-Colson Center for Pancreatic Care, Oregon Health and & Science UniversityBrenden-Colson Center for Pancreatic Care, Oregon Health and & Science UniversityPapé Family Pediatric Research Institute, Oregon Health & Science UniversityPapé Family Pediatric Research Institute, Oregon Health & Science UniversityBrenden-Colson Center for Pancreatic Care, Oregon Health and & Science UniversityPapé Family Pediatric Research Institute, Oregon Health & Science UniversityLipocalin 2 (LCN2) has been recently identified as an endogenous regulator of appetite. Here, using pancreatic cancer as a model of cachexia, the authors demonstrate that LCN2 is a critical mediator of cancer-associated anorexia and may be therapeutically targeted to improve patient outcomes.https://doi.org/10.1038/s41467-021-22361-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Brennan Olson Xinxia Zhu Mason A. Norgard Peter R. Levasseur John T. Butler Abigail Buenafe Kevin G. Burfeind Katherine A. Michaelis Katherine R. Pelz Heike Mendez Jared Edwards Stephanie M. Krasnow Aaron J. Grossberg Daniel L. Marks |
| spellingShingle |
Brennan Olson Xinxia Zhu Mason A. Norgard Peter R. Levasseur John T. Butler Abigail Buenafe Kevin G. Burfeind Katherine A. Michaelis Katherine R. Pelz Heike Mendez Jared Edwards Stephanie M. Krasnow Aaron J. Grossberg Daniel L. Marks Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia Nature Communications |
| author_facet |
Brennan Olson Xinxia Zhu Mason A. Norgard Peter R. Levasseur John T. Butler Abigail Buenafe Kevin G. Burfeind Katherine A. Michaelis Katherine R. Pelz Heike Mendez Jared Edwards Stephanie M. Krasnow Aaron J. Grossberg Daniel L. Marks |
| author_sort |
Brennan Olson |
| title |
Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia |
| title_short |
Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia |
| title_full |
Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia |
| title_fullStr |
Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia |
| title_full_unstemmed |
Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia |
| title_sort |
lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-04-01 |
| description |
Lipocalin 2 (LCN2) has been recently identified as an endogenous regulator of appetite. Here, using pancreatic cancer as a model of cachexia, the authors demonstrate that LCN2 is a critical mediator of cancer-associated anorexia and may be therapeutically targeted to improve patient outcomes. |
| url |
https://doi.org/10.1038/s41467-021-22361-3 |
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