Case report: Primary hemophagocytic syndrome triggered by dengue infection

Case report: Primary hemophagocytic syndrome triggered by dengue infection

HLH is a progressive syndrome of unchecked immune activation and tissue damage. If left untreated, patients with HLH survive for only a few months, due to progressive multi-organ failure. Prompt initiation of treatment for HLH is essential for the survival of affected patients. Several conditions ar...

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Bibliographic Details
Main Authors: Kanta Devi, Natasha Ali
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:IDCases
Subjects:
Primary HLH
Dengue infection
STXBP2 gene
Online Access:http://www.sciencedirect.com/science/article/pii/S2214250921002316
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spelling doaj-ac02ab64a7994bb18254908daa08c8a82021-09-03T04:45:54ZengElsevierIDCases2214-25092021-01-0126e01275Case report: Primary hemophagocytic syndrome triggered by dengue infectionKanta Devi0Natasha Ali1Department of Oncology, Aga Khan University, Karachi, Pakistan; Correspondence to: Department of Oncology, Aga Khan University, Karachi, Pakistan.Department of Pathology and Laboratory Medicine/Oncology, Aga Khan University, Karachi, PakistanHLH is a progressive syndrome of unchecked immune activation and tissue damage. If left untreated, patients with HLH survive for only a few months, due to progressive multi-organ failure. Prompt initiation of treatment for HLH is essential for the survival of affected patients. Several conditions are responsible for triggering HLH in clinically stable patients who respond to treatment of the underlying condition alone. These conditions include infection, rheumatological diseases and lymphoid malignancies. We report a rare case of primary HLH in a 32-year-old female who presented with fever, abdominal pain, pancytopenia and splenomegaly with the triggering factor being Dengue infection.http://www.sciencedirect.com/science/article/pii/S2214250921002316Primary HLHDengue infectionSTXBP2 gene
collection DOAJ
language English
format Article
sources DOAJ
author Kanta Devi
Natasha Ali
spellingShingle Kanta Devi
Natasha Ali
Case report: Primary hemophagocytic syndrome triggered by dengue infection
IDCases
Primary HLH
Dengue infection
STXBP2 gene
author_facet Kanta Devi
Natasha Ali
author_sort Kanta Devi
title Case report: Primary hemophagocytic syndrome triggered by dengue infection
title_short Case report: Primary hemophagocytic syndrome triggered by dengue infection
title_full Case report: Primary hemophagocytic syndrome triggered by dengue infection
title_fullStr Case report: Primary hemophagocytic syndrome triggered by dengue infection
title_full_unstemmed Case report: Primary hemophagocytic syndrome triggered by dengue infection
title_sort case report: primary hemophagocytic syndrome triggered by dengue infection
publisher Elsevier
series IDCases
issn 2214-2509
publishDate 2021-01-01
description HLH is a progressive syndrome of unchecked immune activation and tissue damage. If left untreated, patients with HLH survive for only a few months, due to progressive multi-organ failure. Prompt initiation of treatment for HLH is essential for the survival of affected patients. Several conditions are responsible for triggering HLH in clinically stable patients who respond to treatment of the underlying condition alone. These conditions include infection, rheumatological diseases and lymphoid malignancies. We report a rare case of primary HLH in a 32-year-old female who presented with fever, abdominal pain, pancytopenia and splenomegaly with the triggering factor being Dengue infection.
topic Primary HLH
Dengue infection
STXBP2 gene
url http://www.sciencedirect.com/science/article/pii/S2214250921002316
work_keys_str_mv AT kantadevi casereportprimaryhemophagocyticsyndrometriggeredbydengueinfection
AT natashaali casereportprimaryhemophagocyticsyndrometriggeredbydengueinfection
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