FUNCTIONAL STATE OF THE AUTONOMIC NERVOUS SYSTEM IN RATS AFTER INHALING A HIGHLY DISPERSED AEROSOL FROM THE ELECTRONIC NICOTINE DELIVERY SYSTEM

• Main Authors: Igor Borisovich Korolev, Oksana Vladimirovna Podkaura
• Format: Article
• Language: English
• Published: Science and Innovation Center Publishing House 2018-06-01
• Series: В мире научных открытий
• Subjects: крыса; вейп; вейпинг; вегетативная нервная система; вариабельность ритма сердца
• Online Access: http://journal-s.org/index.php/vmno/article/view/11031

The purpose of the study was to study the functional state of the autonomic nervous system in rats after inhaling a highly dispersed aerosol from the electronic nicotine delivery system. The study was conducted on 20 mature rats. The inversion of the sensitivity of the vegetative nervous system in rats is revealed when a highly dispersed aerosol (vapor) comes from the device simulating an electronic cigarette. With a single exposure to aerosol (steam), a functional imbalance in vegetative regulation of the heart rhythm with a predominance of parasympathicotonia and a failure of neurohumoral autoregulation of the myocardium was recorded in the animals against the backdrop of centralized control of cardiac function against the background of pronounced fluctuations in the adrenergic component. With the increase in exposure to multiple inhalations of aerosol (vapor), pronounced maladaptation of animals is observed, which is associated with autonomic nervous system dysfunction in the form of a decrease in parasympathetic activity and an increase in the tone of the sympathetic department.