Early L-dopa, but not pramipexole, restores basal ganglia activity in partially 6-OHDA-lesioned rats

Early L-dopa, but not pramipexole, restores basal ganglia activity in partially 6-OHDA-lesioned rats

The most appropriate time for the initiation of dopaminergic symptomatic therapy in Parkinson's disease remains debatable. It has been suggested that early correction of basal ganglia pathophysiological abnormalities may have long-term beneficial effects. To test this hypothesis, we investigate...

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Bibliographic Details
Main Authors: C. Marin, M. Bonastre, G. Mengod, R. Cortés, A. Giralt, J.A. Obeso, A.H. Schapira
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
L-dopa
Pramipexole
Dyskinesias
6-Hydroxydopamine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113003537

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