VEGF-A, sVEGFR-1, and sVEGFR-2 in BCR-ABL negative myeloproliferative neoplasms
Background and objective: Data from the literature indicate the relationship between the bone marrow microvessel density and the blood parameters of angiogenesis. The aim of this study was to evaluate selected parameters of angiogenesis (VEGF-A, sVEGFR-1, and sVEGFR-2) and their correlations with wh...
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doaj-ac102f02c934452eb0aa08feb63d608b2020-11-25T01:33:14ZengMDPI AGMedicina1010-660X2017-01-01531343910.1016/j.medici.2017.01.004VEGF-A, sVEGFR-1, and sVEGFR-2 in BCR-ABL negative myeloproliferative neoplasmsGrażyna Gadomska0Katarzyna Stankowska1Joanna Boinska2Robert Ślusarz3Marzena Tylicka4Małgorzata Michalska5Anna Jachalska6Danuta Rość7Department of Hematology and Malignant Diseases of Hematopoietic System, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, PolandDepartment of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, PolandDepartment of Neurological and Neurosurgical Nursing, Faculty of Health Sciences, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, PolandDepartment of Neurological and Neurosurgical Nursing, Faculty of Health Sciences, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, PolandDepartment of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, PolandDepartment of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, PolandDepartment of Hematology and Malignant Diseases of Hematopoietic System, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, PolandDepartment of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, PolandBackground and objective: Data from the literature indicate the relationship between the bone marrow microvessel density and the blood parameters of angiogenesis. The aim of this study was to evaluate selected parameters of angiogenesis (VEGF-A, sVEGFR-1, and sVEGFR-2) and their correlations with white blood cells, platelets, and red blood cells. Materials and methods: The study included 72 patients (mean age, 61.84 years) with myeloproliferative neoplasms (MPNs): essential thrombocythemia (ET) (n = 46), polycythemia vera (PV) (n = 19), and primary myelofibrosis (PMF) (n = 7). Serum VEGF-A, sVEGFR-1, and sVEGFR-2 were determined using the ELISA assay. Results: We observed a significantly higher level of VEGF-A and reduced concentrations of sVEGFR-1 and sVEGFR-2 in the whole group of patients with MPNs as compared to controls. Detailed analysis confirmed significantly higher level of VEGF-A and lower concentration of sVEGFR-2 in each subgroups of MPNs patients. However, sVEGFR-1 concentrations were significantly lower only in PV and ET patients. Conclusions: The study showed an increased level of VEGF-A, which may indicate the intensity of neoangiogenesis in the bone marrow. Decreased sVEGFR-1 and sVEGFR-2 in the blood of patients with MPNs may reflect consumption of these soluble receptors.http://www.sciencedirect.com/science/article/pii/S1010660X17300046BCR-ABL-negative myeloproliferative neoplasmVEGF-AsVEGFR-1sVEGFR-2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Grażyna Gadomska Katarzyna Stankowska Joanna Boinska Robert Ślusarz Marzena Tylicka Małgorzata Michalska Anna Jachalska Danuta Rość |
spellingShingle |
Grażyna Gadomska Katarzyna Stankowska Joanna Boinska Robert Ślusarz Marzena Tylicka Małgorzata Michalska Anna Jachalska Danuta Rość VEGF-A, sVEGFR-1, and sVEGFR-2 in BCR-ABL negative myeloproliferative neoplasms Medicina BCR-ABL-negative myeloproliferative neoplasm VEGF-A sVEGFR-1 sVEGFR-2 |
author_facet |
Grażyna Gadomska Katarzyna Stankowska Joanna Boinska Robert Ślusarz Marzena Tylicka Małgorzata Michalska Anna Jachalska Danuta Rość |
author_sort |
Grażyna Gadomska |
title |
VEGF-A, sVEGFR-1, and sVEGFR-2 in BCR-ABL negative myeloproliferative neoplasms |
title_short |
VEGF-A, sVEGFR-1, and sVEGFR-2 in BCR-ABL negative myeloproliferative neoplasms |
title_full |
VEGF-A, sVEGFR-1, and sVEGFR-2 in BCR-ABL negative myeloproliferative neoplasms |
title_fullStr |
VEGF-A, sVEGFR-1, and sVEGFR-2 in BCR-ABL negative myeloproliferative neoplasms |
title_full_unstemmed |
VEGF-A, sVEGFR-1, and sVEGFR-2 in BCR-ABL negative myeloproliferative neoplasms |
title_sort |
vegf-a, svegfr-1, and svegfr-2 in bcr-abl negative myeloproliferative neoplasms |
publisher |
MDPI AG |
series |
Medicina |
issn |
1010-660X |
publishDate |
2017-01-01 |
description |
Background and objective: Data from the literature indicate the relationship between the bone marrow microvessel density and the blood parameters of angiogenesis. The aim of this study was to evaluate selected parameters of angiogenesis (VEGF-A, sVEGFR-1, and sVEGFR-2) and their correlations with white blood cells, platelets, and red blood cells.
Materials and methods: The study included 72 patients (mean age, 61.84 years) with myeloproliferative neoplasms (MPNs): essential thrombocythemia (ET) (n = 46), polycythemia vera (PV) (n = 19), and primary myelofibrosis (PMF) (n = 7). Serum VEGF-A, sVEGFR-1, and sVEGFR-2 were determined using the ELISA assay.
Results: We observed a significantly higher level of VEGF-A and reduced concentrations of sVEGFR-1 and sVEGFR-2 in the whole group of patients with MPNs as compared to controls. Detailed analysis confirmed significantly higher level of VEGF-A and lower concentration of sVEGFR-2 in each subgroups of MPNs patients. However, sVEGFR-1 concentrations were significantly lower only in PV and ET patients.
Conclusions: The study showed an increased level of VEGF-A, which may indicate the intensity of neoangiogenesis in the bone marrow. Decreased sVEGFR-1 and sVEGFR-2 in the blood of patients with MPNs may reflect consumption of these soluble receptors. |
topic |
BCR-ABL-negative myeloproliferative neoplasm VEGF-A sVEGFR-1 sVEGFR-2 |
url |
http://www.sciencedirect.com/science/article/pii/S1010660X17300046 |
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