Non-Coding RNAs in Castration-Resistant Prostate Cancer: Regulation of Androgen Receptor Signaling and Cancer Metabolism
Hormone-refractory prostate cancer frequently relapses from therapy and inevitably progresses to a bone-metastatic status with no cure. Understanding of the molecular mechanisms conferring resistance to androgen deprivation therapy has the potential to lead to the discovery of novel therapeutic targ...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2015-12-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/16/12/26138 |
id |
doaj-ac195ba9bf514512b573e7a012e15687 |
---|---|
record_format |
Article |
spelling |
doaj-ac195ba9bf514512b573e7a012e156872020-11-24T20:43:47ZengMDPI AGInternational Journal of Molecular Sciences1422-00672015-12-011612289432897810.3390/ijms161226138ijms161226138Non-Coding RNAs in Castration-Resistant Prostate Cancer: Regulation of Androgen Receptor Signaling and Cancer MetabolismJing-Wen Shih0Ling-Yu Wang1Chiu-Lien Hung2Hsing-Jien Kung3Chia-Ling Hsieh4Integrated Translational Lab, The Center of Translational Medicine, Taipei Medical University, Taipei 11031, TaiwanDepartment of Biochemistry and Molecular Medicine, Comprehensive Cancer Center, University of California at Davis, Sacramento, CA 95817, USADepartment of Biochemistry and Molecular Medicine, Comprehensive Cancer Center, University of California at Davis, Sacramento, CA 95817, USAIntegrated Translational Lab, The Center of Translational Medicine, Taipei Medical University, Taipei 11031, TaiwanThe Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, TaiwanHormone-refractory prostate cancer frequently relapses from therapy and inevitably progresses to a bone-metastatic status with no cure. Understanding of the molecular mechanisms conferring resistance to androgen deprivation therapy has the potential to lead to the discovery of novel therapeutic targets for type of prostate cancer with poor prognosis. Progression to castration-resistant prostate cancer (CRPC) is characterized by aberrant androgen receptor (AR) expression and persistent AR signaling activity. Alterations in metabolic activity regulated by oncogenic pathways, such as c-Myc, were found to promote prostate cancer growth during the development of CRPC. Non-coding RNAs represent a diverse family of regulatory transcripts that drive tumorigenesis of prostate cancer and various other cancers by their hyperactivity or diminished function. A number of studies have examined differentially expressed non-coding RNAs in each stage of prostate cancer. Herein, we highlight the emerging impacts of microRNAs and long non-coding RNAs linked to reactivation of the AR signaling axis and reprogramming of the cellular metabolism in prostate cancer. The translational implications of non-coding RNA research for developing new biomarkers and therapeutic strategies for CRPC are also discussed.http://www.mdpi.com/1422-0067/16/12/26138non-coding RNAmicro RNAslong non-coding RNAscastration-resistant prostate cancerandrogen receptorcancer metabolism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jing-Wen Shih Ling-Yu Wang Chiu-Lien Hung Hsing-Jien Kung Chia-Ling Hsieh |
spellingShingle |
Jing-Wen Shih Ling-Yu Wang Chiu-Lien Hung Hsing-Jien Kung Chia-Ling Hsieh Non-Coding RNAs in Castration-Resistant Prostate Cancer: Regulation of Androgen Receptor Signaling and Cancer Metabolism International Journal of Molecular Sciences non-coding RNA micro RNAs long non-coding RNAs castration-resistant prostate cancer androgen receptor cancer metabolism |
author_facet |
Jing-Wen Shih Ling-Yu Wang Chiu-Lien Hung Hsing-Jien Kung Chia-Ling Hsieh |
author_sort |
Jing-Wen Shih |
title |
Non-Coding RNAs in Castration-Resistant Prostate Cancer: Regulation of Androgen Receptor Signaling and Cancer Metabolism |
title_short |
Non-Coding RNAs in Castration-Resistant Prostate Cancer: Regulation of Androgen Receptor Signaling and Cancer Metabolism |
title_full |
Non-Coding RNAs in Castration-Resistant Prostate Cancer: Regulation of Androgen Receptor Signaling and Cancer Metabolism |
title_fullStr |
Non-Coding RNAs in Castration-Resistant Prostate Cancer: Regulation of Androgen Receptor Signaling and Cancer Metabolism |
title_full_unstemmed |
Non-Coding RNAs in Castration-Resistant Prostate Cancer: Regulation of Androgen Receptor Signaling and Cancer Metabolism |
title_sort |
non-coding rnas in castration-resistant prostate cancer: regulation of androgen receptor signaling and cancer metabolism |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2015-12-01 |
description |
Hormone-refractory prostate cancer frequently relapses from therapy and inevitably progresses to a bone-metastatic status with no cure. Understanding of the molecular mechanisms conferring resistance to androgen deprivation therapy has the potential to lead to the discovery of novel therapeutic targets for type of prostate cancer with poor prognosis. Progression to castration-resistant prostate cancer (CRPC) is characterized by aberrant androgen receptor (AR) expression and persistent AR signaling activity. Alterations in metabolic activity regulated by oncogenic pathways, such as c-Myc, were found to promote prostate cancer growth during the development of CRPC. Non-coding RNAs represent a diverse family of regulatory transcripts that drive tumorigenesis of prostate cancer and various other cancers by their hyperactivity or diminished function. A number of studies have examined differentially expressed non-coding RNAs in each stage of prostate cancer. Herein, we highlight the emerging impacts of microRNAs and long non-coding RNAs linked to reactivation of the AR signaling axis and reprogramming of the cellular metabolism in prostate cancer. The translational implications of non-coding RNA research for developing new biomarkers and therapeutic strategies for CRPC are also discussed. |
topic |
non-coding RNA micro RNAs long non-coding RNAs castration-resistant prostate cancer androgen receptor cancer metabolism |
url |
http://www.mdpi.com/1422-0067/16/12/26138 |
work_keys_str_mv |
AT jingwenshih noncodingrnasincastrationresistantprostatecancerregulationofandrogenreceptorsignalingandcancermetabolism AT lingyuwang noncodingrnasincastrationresistantprostatecancerregulationofandrogenreceptorsignalingandcancermetabolism AT chiulienhung noncodingrnasincastrationresistantprostatecancerregulationofandrogenreceptorsignalingandcancermetabolism AT hsingjienkung noncodingrnasincastrationresistantprostatecancerregulationofandrogenreceptorsignalingandcancermetabolism AT chialinghsieh noncodingrnasincastrationresistantprostatecancerregulationofandrogenreceptorsignalingandcancermetabolism |
_version_ |
1716818918596673536 |