SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A
S-adenosylmethionine (SAM) is the methyl donor for nearly all cellular methylation events. Cells regulate intracellular SAM levels through intron detention of MAT2A, the only SAM synthetase expressed in most cells. The N6-adenosine methyltransferase METTL16 promotes splicing of the MAT2A detained in...
Main Authors: | Anna M Scarborough, Juliana N Flaherty, Olga V Hunter, Kuanqing Liu, Ashwani Kumar, Chao Xing, Benjamin P Tu, Nicholas K Conrad |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-05-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/64930 |
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