Constraints on eQTL Fine Mapping in the Presence of Multisite Local Regulation of Gene Expression

Constraints on eQTL Fine Mapping in the Presence of Multisite Local Regulation of Gene Expression

Expression quantitative trait locus (eQTL) detection has emerged as an important tool for unraveling of the relationship between genetic risk factors and disease or clinical phenotypes. Most studies use single marker linear regression to discover primary signals, followed by sequential conditional m...

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Bibliographic Details
Main Authors: Biao Zeng, Luke R. Lloyd-Jones, Alexander Holloway, Urko M. Marigorta, Andres Metspalu, Grant W. Montgomery, Tonu Esko, Kenneth L. Brigham, Arshed A. Quyyumi, Youssef Idaghdour, Jian Yang, Peter M. Visscher, Joseph E. Powell, Greg Gibson
Format: Article
Language:English
Published: Oxford University Press 2017-08-01
Series:G3: Genes, Genomes, Genetics
Subjects:
fine mapping
linkage disequilibrium
multivariable regression
colocalization
gene regulation
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.043752

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