Rapid, two-pot procedure for the synthesis of dihydropyridinones; total synthesis of aza-goniothalamin
A fast, protecting-group-free synthesis of dihydropyridinones has been developed. Starting from commercially available aldehydes, a novel one-pot amidoallylation gave access to diene compounds in good yields. Ring-closing metathesis conditions were then employed to produce the target dihydropyridino...
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2020-01-01
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| Series: | Beilstein Journal of Organic Chemistry |
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| Online Access: | https://doi.org/10.3762/bjoc.16.15 |
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doaj-ac336ff30b444eed838411408f9b243f2021-02-02T06:49:49ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972020-01-0116113513910.3762/bjoc.16.151860-5397-16-15Rapid, two-pot procedure for the synthesis of dihydropyridinones; total synthesis of aza-goniothalaminThomas J. Cogswell0Craig S. Donald1Rodolfo Marquez2School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, U.KLucideon Limited., Queens Road, Penkhull, Stoke-on-Trent, Staffordshire, ST4 7LQ, U.KSchool of Chemistry, University of Glasgow, Glasgow, G12 8QQ, U.KA fast, protecting-group-free synthesis of dihydropyridinones has been developed. Starting from commercially available aldehydes, a novel one-pot amidoallylation gave access to diene compounds in good yields. Ring-closing metathesis conditions were then employed to produce the target dihydropyridinones efficiently and in high yields.https://doi.org/10.3762/bjoc.16.15amidoallylationaza-goniothalamindihydropyridinonesprotecting-group-freering-closing metathesistwo-pot procedure |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Thomas J. Cogswell Craig S. Donald Rodolfo Marquez |
| spellingShingle |
Thomas J. Cogswell Craig S. Donald Rodolfo Marquez Rapid, two-pot procedure for the synthesis of dihydropyridinones; total synthesis of aza-goniothalamin Beilstein Journal of Organic Chemistry amidoallylation aza-goniothalamin dihydropyridinones protecting-group-free ring-closing metathesis two-pot procedure |
| author_facet |
Thomas J. Cogswell Craig S. Donald Rodolfo Marquez |
| author_sort |
Thomas J. Cogswell |
| title |
Rapid, two-pot procedure for the synthesis of dihydropyridinones; total synthesis of aza-goniothalamin |
| title_short |
Rapid, two-pot procedure for the synthesis of dihydropyridinones; total synthesis of aza-goniothalamin |
| title_full |
Rapid, two-pot procedure for the synthesis of dihydropyridinones; total synthesis of aza-goniothalamin |
| title_fullStr |
Rapid, two-pot procedure for the synthesis of dihydropyridinones; total synthesis of aza-goniothalamin |
| title_full_unstemmed |
Rapid, two-pot procedure for the synthesis of dihydropyridinones; total synthesis of aza-goniothalamin |
| title_sort |
rapid, two-pot procedure for the synthesis of dihydropyridinones; total synthesis of aza-goniothalamin |
| publisher |
Beilstein-Institut |
| series |
Beilstein Journal of Organic Chemistry |
| issn |
1860-5397 |
| publishDate |
2020-01-01 |
| description |
A fast, protecting-group-free synthesis of dihydropyridinones has been developed. Starting from commercially available aldehydes, a novel one-pot amidoallylation gave access to diene compounds in good yields. Ring-closing metathesis conditions were then employed to produce the target dihydropyridinones efficiently and in high yields. |
| topic |
amidoallylation aza-goniothalamin dihydropyridinones protecting-group-free ring-closing metathesis two-pot procedure |
| url |
https://doi.org/10.3762/bjoc.16.15 |
| work_keys_str_mv |
AT thomasjcogswell rapidtwopotprocedureforthesynthesisofdihydropyridinonestotalsynthesisofazagoniothalamin AT craigsdonald rapidtwopotprocedureforthesynthesisofdihydropyridinonestotalsynthesisofazagoniothalamin AT rodolfomarquez rapidtwopotprocedureforthesynthesisofdihydropyridinonestotalsynthesisofazagoniothalamin |
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1724300531847921664 |