Hoffmann's syndrome: a case report
This syndrome is characterized by the presence of hypothyroidism with myxoedema, muscle stiffness and pseudo hypertrophy. We describe the disorder in a 21 year old male, who got admitted with complaints of generalized weakness, cold intolerance, constipation, and hoarse voice, difficulty in walking...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | deu |
Published: |
German Medical Science GMS Publishing House
2005-07-01
|
Series: | GMS German Medical Science |
Subjects: | |
Online Access: | http://www.egms.de/en/gms/2005-3/000023.shtml |
id |
doaj-ac40d08aef9d42e0a2ff0b4a7b0caa61 |
---|---|
record_format |
Article |
spelling |
doaj-ac40d08aef9d42e0a2ff0b4a7b0caa612020-11-25T02:19:37ZdeuGerman Medical Science GMS Publishing HouseGMS German Medical Science1612-31742005-07-013Doc05Hoffmann's syndrome: a case reportIbrahim, MohammadRather, Abdul RashidHussain, ShowkatKundal, Darshan LalTak, ShahidAhmad, ManzoorKak, ManishKadri, Syed ManzoorKhan, Ghulam QadirHassan, GhulamQureshi, WaseemSikander, SabiaThis syndrome is characterized by the presence of hypothyroidism with myxoedema, muscle stiffness and pseudo hypertrophy. We describe the disorder in a 21 year old male, who got admitted with complaints of generalized weakness, cold intolerance, constipation, and hoarse voice, difficulty in walking and progressive enlargement of muscles of thighs and back with crampy pains for two years. Examination revealed mild mental retardation, enlarged tongue, dry and rough skin, enlargement of thighs and back muscles, motor weakness in flexors of hips and knees with delayed relaxation of deep tendon reflexes. Investigations revealed evidence of hypothyroidism with marked elevation of muscle enzymes. Following institution of replacement therapy with thyroxine, the patient showed marked clinical and biochemical improvements after six months, but insignificant decrease in muscle mass. In this report we review relevant literature.http://www.egms.de/en/gms/2005-3/000023.shtmlhypothyroidismmyopathypseudohypertrophy |
collection |
DOAJ |
language |
deu |
format |
Article |
sources |
DOAJ |
author |
Ibrahim, Mohammad Rather, Abdul Rashid Hussain, Showkat Kundal, Darshan Lal Tak, Shahid Ahmad, Manzoor Kak, Manish Kadri, Syed Manzoor Khan, Ghulam Qadir Hassan, Ghulam Qureshi, Waseem Sikander, Sabia |
spellingShingle |
Ibrahim, Mohammad Rather, Abdul Rashid Hussain, Showkat Kundal, Darshan Lal Tak, Shahid Ahmad, Manzoor Kak, Manish Kadri, Syed Manzoor Khan, Ghulam Qadir Hassan, Ghulam Qureshi, Waseem Sikander, Sabia Hoffmann's syndrome: a case report GMS German Medical Science hypothyroidism myopathy pseudohypertrophy |
author_facet |
Ibrahim, Mohammad Rather, Abdul Rashid Hussain, Showkat Kundal, Darshan Lal Tak, Shahid Ahmad, Manzoor Kak, Manish Kadri, Syed Manzoor Khan, Ghulam Qadir Hassan, Ghulam Qureshi, Waseem Sikander, Sabia |
author_sort |
Ibrahim, Mohammad |
title |
Hoffmann's syndrome: a case report |
title_short |
Hoffmann's syndrome: a case report |
title_full |
Hoffmann's syndrome: a case report |
title_fullStr |
Hoffmann's syndrome: a case report |
title_full_unstemmed |
Hoffmann's syndrome: a case report |
title_sort |
hoffmann's syndrome: a case report |
publisher |
German Medical Science GMS Publishing House |
series |
GMS German Medical Science |
issn |
1612-3174 |
publishDate |
2005-07-01 |
description |
This syndrome is characterized by the presence of hypothyroidism with myxoedema, muscle stiffness and pseudo hypertrophy. We describe the disorder in a 21 year old male, who got admitted with complaints of generalized weakness, cold intolerance, constipation, and hoarse voice, difficulty in walking and progressive enlargement of muscles of thighs and back with crampy pains for two years. Examination revealed mild mental retardation, enlarged tongue, dry and rough skin, enlargement of thighs and back muscles, motor weakness in flexors of hips and knees with delayed relaxation of deep tendon reflexes. Investigations revealed evidence of hypothyroidism with marked elevation of muscle enzymes. Following institution of replacement therapy with thyroxine, the patient showed marked clinical and biochemical improvements after six months, but insignificant decrease in muscle mass. In this report we review relevant literature. |
topic |
hypothyroidism myopathy pseudohypertrophy |
url |
http://www.egms.de/en/gms/2005-3/000023.shtml |
work_keys_str_mv |
AT ibrahimmohammad hoffmannssyndromeacasereport AT ratherabdulrashid hoffmannssyndromeacasereport AT hussainshowkat hoffmannssyndromeacasereport AT kundaldarshanlal hoffmannssyndromeacasereport AT takshahid hoffmannssyndromeacasereport AT ahmadmanzoor hoffmannssyndromeacasereport AT kakmanish hoffmannssyndromeacasereport AT kadrisyedmanzoor hoffmannssyndromeacasereport AT khanghulamqadir hoffmannssyndromeacasereport AT hassanghulam hoffmannssyndromeacasereport AT qureshiwaseem hoffmannssyndromeacasereport AT sikandersabia hoffmannssyndromeacasereport |
_version_ |
1724875509850963968 |