Kiwifruit Alleviates Learning and Memory Deficits Induced by Pb through Antioxidation and Inhibition of Microglia Activation In Vitro and In Vivo
Lead (Pb) exposure, in particular during early postnatal life, increases susceptibility to cognitive dysfunction and neurodegenerative outcomes. The detrimental effect of Pb exposure is basically due to an increasing ROS production which overcomes the antioxidant systems and finally leads to cogniti...
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Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2017/5645324 |
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doaj-ac4321d98ed6492e9b73f8851852166b2020-11-24T21:25:10ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942017-01-01201710.1155/2017/56453245645324Kiwifruit Alleviates Learning and Memory Deficits Induced by Pb through Antioxidation and Inhibition of Microglia Activation In Vitro and In VivoWei-Zhen Xue0Qian-Qian Yang1Yiwen Chen2Rong-Xin Zou3Dong Xing4Yi Xu5Yong-Sheng Liu6Hui-Li Wang7School of Food Science and Engineering, Hefei University of Technology, Hefei, Anhui 230009, ChinaSchool of Food Science and Engineering, Hefei University of Technology, Hefei, Anhui 230009, ChinaHefei No. 8 High School, Hefei 230038, ChinaSchool of Food Science and Engineering, Hefei University of Technology, Hefei, Anhui 230009, ChinaSchool of Food Science and Engineering, Hefei University of Technology, Hefei, Anhui 230009, ChinaSchool of Food Science and Engineering, Hefei University of Technology, Hefei, Anhui 230009, ChinaSchool of Food Science and Engineering, Hefei University of Technology, Hefei, Anhui 230009, ChinaSchool of Food Science and Engineering, Hefei University of Technology, Hefei, Anhui 230009, ChinaLead (Pb) exposure, in particular during early postnatal life, increases susceptibility to cognitive dysfunction and neurodegenerative outcomes. The detrimental effect of Pb exposure is basically due to an increasing ROS production which overcomes the antioxidant systems and finally leads to cognitive dysfunction. Kiwifruit is rich in the antioxidants like vitamin C and polyphenols. This study aims to investigate the effects and mechanism of kiwifruit to alleviate learning and memory deficits induced by Pb exposure. Sprague-Dawley (SD) rat pups acquired Pb indirectly through their mothers during lactation period and after postnatal day 21 (PND21) directly acquired Pb by themselves. Five kinds of kiwifruits were collected in this study and the amounts of vitamin C and polyphenols in them were measured and the antioxidation effects were determined. Among them, Qinmei kiwifruit (Qm) showed the strongest antioxidation effects in vitro. In vivo, Qm significantly repaired Pb-induced learning and memory deficits and dendritic spine loss. In addition, Pb compromised the enzymatic activity and transcriptional levels of SOD and GSH-Px and decreased the microglial activation, which, to some extent, could be reversed by Qm kiwifruit administration. The results suggest that kiwifruit could alleviate Pb-induced cognitive deficits possibly through antioxidative stress and microglia inactivation. Consequently, kiwifruit could be potentially regarded as the functional food favorable in the prevention and treatment of Pb intoxication.http://dx.doi.org/10.1155/2017/5645324 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wei-Zhen Xue Qian-Qian Yang Yiwen Chen Rong-Xin Zou Dong Xing Yi Xu Yong-Sheng Liu Hui-Li Wang |
spellingShingle |
Wei-Zhen Xue Qian-Qian Yang Yiwen Chen Rong-Xin Zou Dong Xing Yi Xu Yong-Sheng Liu Hui-Li Wang Kiwifruit Alleviates Learning and Memory Deficits Induced by Pb through Antioxidation and Inhibition of Microglia Activation In Vitro and In Vivo Oxidative Medicine and Cellular Longevity |
author_facet |
Wei-Zhen Xue Qian-Qian Yang Yiwen Chen Rong-Xin Zou Dong Xing Yi Xu Yong-Sheng Liu Hui-Li Wang |
author_sort |
Wei-Zhen Xue |
title |
Kiwifruit Alleviates Learning and Memory Deficits Induced by Pb through Antioxidation and Inhibition of Microglia Activation In Vitro and In Vivo |
title_short |
Kiwifruit Alleviates Learning and Memory Deficits Induced by Pb through Antioxidation and Inhibition of Microglia Activation In Vitro and In Vivo |
title_full |
Kiwifruit Alleviates Learning and Memory Deficits Induced by Pb through Antioxidation and Inhibition of Microglia Activation In Vitro and In Vivo |
title_fullStr |
Kiwifruit Alleviates Learning and Memory Deficits Induced by Pb through Antioxidation and Inhibition of Microglia Activation In Vitro and In Vivo |
title_full_unstemmed |
Kiwifruit Alleviates Learning and Memory Deficits Induced by Pb through Antioxidation and Inhibition of Microglia Activation In Vitro and In Vivo |
title_sort |
kiwifruit alleviates learning and memory deficits induced by pb through antioxidation and inhibition of microglia activation in vitro and in vivo |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2017-01-01 |
description |
Lead (Pb) exposure, in particular during early postnatal life, increases susceptibility to cognitive dysfunction and neurodegenerative outcomes. The detrimental effect of Pb exposure is basically due to an increasing ROS production which overcomes the antioxidant systems and finally leads to cognitive dysfunction. Kiwifruit is rich in the antioxidants like vitamin C and polyphenols. This study aims to investigate the effects and mechanism of kiwifruit to alleviate learning and memory deficits induced by Pb exposure. Sprague-Dawley (SD) rat pups acquired Pb indirectly through their mothers during lactation period and after postnatal day 21 (PND21) directly acquired Pb by themselves. Five kinds of kiwifruits were collected in this study and the amounts of vitamin C and polyphenols in them were measured and the antioxidation effects were determined. Among them, Qinmei kiwifruit (Qm) showed the strongest antioxidation effects in vitro. In vivo, Qm significantly repaired Pb-induced learning and memory deficits and dendritic spine loss. In addition, Pb compromised the enzymatic activity and transcriptional levels of SOD and GSH-Px and decreased the microglial activation, which, to some extent, could be reversed by Qm kiwifruit administration. The results suggest that kiwifruit could alleviate Pb-induced cognitive deficits possibly through antioxidative stress and microglia inactivation. Consequently, kiwifruit could be potentially regarded as the functional food favorable in the prevention and treatment of Pb intoxication. |
url |
http://dx.doi.org/10.1155/2017/5645324 |
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