Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal

Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal

Doxorubicin (Dox), an antitumor antibiotic, has therapeutic effects on many kinds of tumors. However, Dox can produce some serious side effects that limit its clinical application. Thus, exploration of effective drug targets or active lead compounds against Dox-induced organ damage is necessary. Dio...

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Bibliographic Details
Main Authors: Shasha Song, Liang Chu, Huifang Liang, Jin Chen, Junnan Liang, Zhao Huang, Bixiang Zhang, Xiaoping Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
dioscin
doxorubicin
liver injury
Sirt1/FOXO1/NF-κB signal
oxidative stress
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01030/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.01030/full

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