The Ribosome Biogenesis—Cancer Connection

Multifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its relationship with cell proliferation: 1) allowed the understanding of the reasons for the nucleolar changes in cancer cel...

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Main Authors:	Marianna Penzo, Lorenzo Montanaro, Davide Treré, Massimo Derenzini
Format:	Article
Language:	English
Published:	MDPI AG 2019-01-01
Series:	Cells
Subjects:	nucleolus ribosome biogenesis ribosomal proteins p53 AgNORs tumour pathology chronic inflammatory diseases ribosomopathies tumourigenesis cancer chemotherapy
Online Access:	http://www.mdpi.com/2073-4409/8/1/55

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spelling	doaj-ac53d0f473ca4b7fb3e2f6aefc4d3afd2020-11-25T00:45:58ZengMDPI AGCells2073-44092019-01-01815510.3390/cells8010055cells8010055The Ribosome Biogenesis—Cancer ConnectionMarianna Penzo0Lorenzo Montanaro1Davide Treré2Massimo Derenzini3Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum-University of Bologna, 40138 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum-University of Bologna, 40138 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum-University of Bologna, 40138 Bologna, ItalyAlma Mater Studiorum-University of Bologna, 40126 Bologna, ItalyMultifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its relationship with cell proliferation: 1) allowed the understanding of the reasons for the nucleolar changes in cancer cells and their exploitation in tumor pathology, 2) defined the importance of the inhibition of ribosome biogenesis in cancer chemotherapy and 3) focused the attention on alterations of ribosome biogenesis in the pathogenesis of cancer. This review summarizes the research milestones regarding these relevant relationships between ribosome biogenesis and cancer. The structure and function of the nucleolus will also be briefly described.http://www.mdpi.com/2073-4409/8/1/55nucleolusribosome biogenesisribosomal proteinsp53AgNORstumour pathologychronic inflammatory diseasesribosomopathiestumourigenesiscancer chemotherapy
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Marianna Penzo Lorenzo Montanaro Davide Treré Massimo Derenzini
spellingShingle	Marianna Penzo Lorenzo Montanaro Davide Treré Massimo Derenzini The Ribosome Biogenesis—Cancer Connection Cells nucleolus ribosome biogenesis ribosomal proteins p53 AgNORs tumour pathology chronic inflammatory diseases ribosomopathies tumourigenesis cancer chemotherapy
author_facet	Marianna Penzo Lorenzo Montanaro Davide Treré Massimo Derenzini
author_sort	Marianna Penzo
title	The Ribosome Biogenesis—Cancer Connection
title_short	The Ribosome Biogenesis—Cancer Connection
title_full	The Ribosome Biogenesis—Cancer Connection
title_fullStr	The Ribosome Biogenesis—Cancer Connection
title_full_unstemmed	The Ribosome Biogenesis—Cancer Connection
title_sort	ribosome biogenesis—cancer connection
publisher	MDPI AG
series	Cells
issn	2073-4409
publishDate	2019-01-01
description	Multifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its relationship with cell proliferation: 1) allowed the understanding of the reasons for the nucleolar changes in cancer cells and their exploitation in tumor pathology, 2) defined the importance of the inhibition of ribosome biogenesis in cancer chemotherapy and 3) focused the attention on alterations of ribosome biogenesis in the pathogenesis of cancer. This review summarizes the research milestones regarding these relevant relationships between ribosome biogenesis and cancer. The structure and function of the nucleolus will also be briefly described.
topic	nucleolus ribosome biogenesis ribosomal proteins p53 AgNORs tumour pathology chronic inflammatory diseases ribosomopathies tumourigenesis cancer chemotherapy
url	http://www.mdpi.com/2073-4409/8/1/55
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The Ribosome Biogenesis—Cancer Connection

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