Effects of Basic Amino Acids and Their Derivatives on SARS-CoV-2 and Influenza-A Virus Infection
Amino acids have been implicated with virus infection and replication. Here, we demonstrate the effects of two basic amino acids, arginine and lysine, and their ester derivatives on infection of two enveloped viruses, SARS-CoV-2, and influenza A virus. We found that lysine and its ester derivative c...
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doaj-ac5f52dce5cd4d25bbb003c8d5afa9492021-07-23T14:11:28ZengMDPI AGViruses1999-49152021-07-01131301130110.3390/v13071301Effects of Basic Amino Acids and Their Derivatives on SARS-CoV-2 and Influenza-A Virus InfectionIvonne Melano0Li-Lan Kuo1Yan-Chung Lo2Po-Wei Sung3Ni Tien4Wen-Chi Su5Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 40402, TaiwanResearch Center for Emerging Viruses, China Medical University Hospital, Taichung 40402, TaiwanSinphar Pharmaceutical Co., Ltd., Sinphar Group, Yilan 269, TaiwanSchool of Medicine, China Medical University, Taichung 40402, TaiwanDepartment of Laboratory Medicine, China Medical University Hospital, Taichung 40402, TaiwanGraduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 40402, TaiwanAmino acids have been implicated with virus infection and replication. Here, we demonstrate the effects of two basic amino acids, arginine and lysine, and their ester derivatives on infection of two enveloped viruses, SARS-CoV-2, and influenza A virus. We found that lysine and its ester derivative can efficiently block infection of both viruses in vitro. Furthermore, the arginine ester derivative caused a significant boost in virus infection. Studies on their mechanism of action revealed that the compounds potentially disturb virus uncoating rather than virus attachment and endosomal acidification. Our findings suggest that lysine supplementation and the reduction of arginine-rich food intake can be considered as prophylactic and therapeutic regimens against these viruses while also providing a paradigm for the development of broad-spectrum antivirals.https://www.mdpi.com/1999-4915/13/7/1301SARS-CoV-2COVID-19influenza A viruslysineargininedisease prevention |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ivonne Melano Li-Lan Kuo Yan-Chung Lo Po-Wei Sung Ni Tien Wen-Chi Su |
spellingShingle |
Ivonne Melano Li-Lan Kuo Yan-Chung Lo Po-Wei Sung Ni Tien Wen-Chi Su Effects of Basic Amino Acids and Their Derivatives on SARS-CoV-2 and Influenza-A Virus Infection Viruses SARS-CoV-2 COVID-19 influenza A virus lysine arginine disease prevention |
author_facet |
Ivonne Melano Li-Lan Kuo Yan-Chung Lo Po-Wei Sung Ni Tien Wen-Chi Su |
author_sort |
Ivonne Melano |
title |
Effects of Basic Amino Acids and Their Derivatives on SARS-CoV-2 and Influenza-A Virus Infection |
title_short |
Effects of Basic Amino Acids and Their Derivatives on SARS-CoV-2 and Influenza-A Virus Infection |
title_full |
Effects of Basic Amino Acids and Their Derivatives on SARS-CoV-2 and Influenza-A Virus Infection |
title_fullStr |
Effects of Basic Amino Acids and Their Derivatives on SARS-CoV-2 and Influenza-A Virus Infection |
title_full_unstemmed |
Effects of Basic Amino Acids and Their Derivatives on SARS-CoV-2 and Influenza-A Virus Infection |
title_sort |
effects of basic amino acids and their derivatives on sars-cov-2 and influenza-a virus infection |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2021-07-01 |
description |
Amino acids have been implicated with virus infection and replication. Here, we demonstrate the effects of two basic amino acids, arginine and lysine, and their ester derivatives on infection of two enveloped viruses, SARS-CoV-2, and influenza A virus. We found that lysine and its ester derivative can efficiently block infection of both viruses in vitro. Furthermore, the arginine ester derivative caused a significant boost in virus infection. Studies on their mechanism of action revealed that the compounds potentially disturb virus uncoating rather than virus attachment and endosomal acidification. Our findings suggest that lysine supplementation and the reduction of arginine-rich food intake can be considered as prophylactic and therapeutic regimens against these viruses while also providing a paradigm for the development of broad-spectrum antivirals. |
topic |
SARS-CoV-2 COVID-19 influenza A virus lysine arginine disease prevention |
url |
https://www.mdpi.com/1999-4915/13/7/1301 |
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