IL-25 Could Be Involved in the Development of Allergic Rhinitis Sensitized to House Dust Mite
Background and Purpose. When house dust mite (HDM), a common allergen, comes into the mucosal membrane, it may stimulate innate immunity. However, the precise role of interleukin- (IL-) 25 in the development of HDM-induced nasal allergic inflammation is still unclear. Therefore, we investigated the...
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doaj-ac78127435f244e6b4e60ab709fdd20e2020-11-24T22:38:58ZengHindawi LimitedMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/39080493908049IL-25 Could Be Involved in the Development of Allergic Rhinitis Sensitized to House Dust MiteDae Woo Kim0Dong-Kyu Kim1Kyoung Mi Eun2Jun-Sang Bae3Young-Jun Chung4Jun Xu5Yong Min Kim6Ji-Hun Mo7Department of Otorhinolaryngology-Head and Neck Surgery, Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, Republic of KoreaDepartment of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Research Institute for Medical Science, Chungnam National University School of Medicine, Daejeon, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Research Institute for Medical Science, Chungnam National University School of Medicine, Daejeon, Republic of KoreaDepartment of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, Republic of KoreaBackground and Purpose. When house dust mite (HDM), a common allergen, comes into the mucosal membrane, it may stimulate innate immunity. However, the precise role of interleukin- (IL-) 25 in the development of HDM-induced nasal allergic inflammation is still unclear. Therefore, we investigated the role of IL-25 in allergic rhinitis (AR) patients sensitized to HDM. Methods. To confirm the production of IL-25 in human nasal epithelial cells (HNECs), we stimulated HNECs. IL-25 expression in the nasal mucosa from control, non-AR (NAR) patients, and HDM-sensitized AR patients was assessed using immunohistochemistry, and quantitative reverse transcription PCR. Correlations between IL-25 and other inflammatory markers were explored. Results. An in vitro study showed significantly elevated concentrations of IL-25 in the HNEC samples with highest doses of HDM. Nasal tissues from AR patients sensitized to HDM showed significantly higher IL-25 expression, compared to those from the control or NAR patients. Moreover, the expression of IL-25 in nasal tissues from AR patients sensitized to HDM was positively associated with Th2 markers, such as ECP and GATA3. Conclusions. IL-25 expression increased with high-dose HDM stimulation and was related to Th2 markers. Therefore, IL-25 neutralization might offer a new strategy for treating patients with HDM-sensitized AR.http://dx.doi.org/10.1155/2017/3908049 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dae Woo Kim Dong-Kyu Kim Kyoung Mi Eun Jun-Sang Bae Young-Jun Chung Jun Xu Yong Min Kim Ji-Hun Mo |
spellingShingle |
Dae Woo Kim Dong-Kyu Kim Kyoung Mi Eun Jun-Sang Bae Young-Jun Chung Jun Xu Yong Min Kim Ji-Hun Mo IL-25 Could Be Involved in the Development of Allergic Rhinitis Sensitized to House Dust Mite Mediators of Inflammation |
author_facet |
Dae Woo Kim Dong-Kyu Kim Kyoung Mi Eun Jun-Sang Bae Young-Jun Chung Jun Xu Yong Min Kim Ji-Hun Mo |
author_sort |
Dae Woo Kim |
title |
IL-25 Could Be Involved in the Development of Allergic Rhinitis Sensitized to House Dust Mite |
title_short |
IL-25 Could Be Involved in the Development of Allergic Rhinitis Sensitized to House Dust Mite |
title_full |
IL-25 Could Be Involved in the Development of Allergic Rhinitis Sensitized to House Dust Mite |
title_fullStr |
IL-25 Could Be Involved in the Development of Allergic Rhinitis Sensitized to House Dust Mite |
title_full_unstemmed |
IL-25 Could Be Involved in the Development of Allergic Rhinitis Sensitized to House Dust Mite |
title_sort |
il-25 could be involved in the development of allergic rhinitis sensitized to house dust mite |
publisher |
Hindawi Limited |
series |
Mediators of Inflammation |
issn |
0962-9351 1466-1861 |
publishDate |
2017-01-01 |
description |
Background and Purpose. When house dust mite (HDM), a common allergen, comes into the mucosal membrane, it may stimulate innate immunity. However, the precise role of interleukin- (IL-) 25 in the development of HDM-induced nasal allergic inflammation is still unclear. Therefore, we investigated the role of IL-25 in allergic rhinitis (AR) patients sensitized to HDM. Methods. To confirm the production of IL-25 in human nasal epithelial cells (HNECs), we stimulated HNECs. IL-25 expression in the nasal mucosa from control, non-AR (NAR) patients, and HDM-sensitized AR patients was assessed using immunohistochemistry, and quantitative reverse transcription PCR. Correlations between IL-25 and other inflammatory markers were explored. Results. An in vitro study showed significantly elevated concentrations of IL-25 in the HNEC samples with highest doses of HDM. Nasal tissues from AR patients sensitized to HDM showed significantly higher IL-25 expression, compared to those from the control or NAR patients. Moreover, the expression of IL-25 in nasal tissues from AR patients sensitized to HDM was positively associated with Th2 markers, such as ECP and GATA3. Conclusions. IL-25 expression increased with high-dose HDM stimulation and was related to Th2 markers. Therefore, IL-25 neutralization might offer a new strategy for treating patients with HDM-sensitized AR. |
url |
http://dx.doi.org/10.1155/2017/3908049 |
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