Potential genetic polymorphisms predicting polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a heterogenous endocrine disorder with typical symptoms of oligomenorrhoea, hyperandrogenism, hirsutism, obesity, insulin resistance and increased risk of type 2 diabetes mellitus. Extensive evidence indicates that PCOS is a genetic disease and numerous biochem...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2018-05-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | http://www.endocrineconnections.com/content/7/5/R187.full |
| Summary: | Polycystic ovary syndrome (PCOS) is a heterogenous endocrine disorder with typical
symptoms of oligomenorrhoea, hyperandrogenism, hirsutism, obesity, insulin resistance
and increased risk of type 2 diabetes mellitus. Extensive evidence indicates that PCOS
is a genetic disease and numerous biochemical pathways have been linked with its
pathogenesis. A number of genes from these pathways have been investigated, which
include those involved with steroid hormone biosynthesis and metabolism, action of
gonadotropin and gonadal hormones, folliculogenesis, obesity and energy regulation,
insulin secretion and action and many others. In this review, we summarize the historical
and recent findings in genetic polymorphisms of PCOS from the relevant publications
and outline some genetic polymorphisms that are potentially associated with the risk of
PCOS. This information could uncover candidate genes associating with PCOS, which will
be valuable for the development of novel diagnostic and treatment platforms for PCOS
patients. |
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| ISSN: | 2049-3614 2049-3614 |