Glycated albumin and its variability as an indicator of cardiovascular autonomic neuropathy development in type 2 diabetic patients
Abstract Background We investigated whether glycated albumin (GA) and its variability are associated with cardiovascular autonomic neuropathy (CAN) and further compared their associations with glycated hemoglobin (HbA1c). Methods This retrospective longitudinal study included 498 type 2 diabetic pat...
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doaj-ac7f0b1bf12141b4b7fecea03c57a32c2020-11-24T23:06:00ZengBMCCardiovascular Diabetology1475-28402017-10-011611910.1186/s12933-017-0619-2Glycated albumin and its variability as an indicator of cardiovascular autonomic neuropathy development in type 2 diabetic patientsJi Eun Jun0Seung-Eun Lee1You-Bin Lee2Ji Yeon Ahn3Gyuri Kim4Sang-Man Jin5Kyu Yeon Hur6Moon-Kyu Lee7Jae Hyeon Kim8Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineAbstract Background We investigated whether glycated albumin (GA) and its variability are associated with cardiovascular autonomic neuropathy (CAN) and further compared their associations with glycated hemoglobin (HbA1c). Methods This retrospective longitudinal study included 498 type 2 diabetic patients without CAN. CAN was defined as at least two abnormal results in parasympathetic tests or presence of orthostatic hypotension. The mean, standard deviation (SD), and coefficient of variance (CV) were calculated from consecutively measured GA (median 7 times) and HbA1c levels (median 8 times) over 2 years. Logistic regression analysis was used to compare the associations between CAN and GA- or HbA1c-related parameters. Receiver operating characteristic (ROC) curve analysis was used to compare the predictive power for CAN between GA- and HbA1c-related parameters. Results A total of 53 subjects (10.6%) developed CAN over 2 years. The mean, SD, and CV of GA or HbA1c were significantly higher in subjects with CAN. Higher mean GA and GA variability were associated with the risk of developing CAN, independent of conventional risk factors and HbA1c. In ROC curve analysis, the SD and CV of GA showed higher predictive value for CAN compared to the SD and CV of HbA1c, whereas the predictive value of mean GA did not differ from that of mean HbA1c. The mean, SD, and CV of GA showed additive predictive power to detect CAN development along with mean HbA1c. Conclusions Higher serum GA and its variability are significantly associated with the risk of developing CAN. Serum GA might be a useful indicator for diabetic complications and can enhance HbA1c’s modest clinical prediction for CAN.http://link.springer.com/article/10.1186/s12933-017-0619-2Glycated albuminCardiovascular autonomic neuropathyGlycemic variabilityType 2 diabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ji Eun Jun Seung-Eun Lee You-Bin Lee Ji Yeon Ahn Gyuri Kim Sang-Man Jin Kyu Yeon Hur Moon-Kyu Lee Jae Hyeon Kim |
spellingShingle |
Ji Eun Jun Seung-Eun Lee You-Bin Lee Ji Yeon Ahn Gyuri Kim Sang-Man Jin Kyu Yeon Hur Moon-Kyu Lee Jae Hyeon Kim Glycated albumin and its variability as an indicator of cardiovascular autonomic neuropathy development in type 2 diabetic patients Cardiovascular Diabetology Glycated albumin Cardiovascular autonomic neuropathy Glycemic variability Type 2 diabetes |
author_facet |
Ji Eun Jun Seung-Eun Lee You-Bin Lee Ji Yeon Ahn Gyuri Kim Sang-Man Jin Kyu Yeon Hur Moon-Kyu Lee Jae Hyeon Kim |
author_sort |
Ji Eun Jun |
title |
Glycated albumin and its variability as an indicator of cardiovascular autonomic neuropathy development in type 2 diabetic patients |
title_short |
Glycated albumin and its variability as an indicator of cardiovascular autonomic neuropathy development in type 2 diabetic patients |
title_full |
Glycated albumin and its variability as an indicator of cardiovascular autonomic neuropathy development in type 2 diabetic patients |
title_fullStr |
Glycated albumin and its variability as an indicator of cardiovascular autonomic neuropathy development in type 2 diabetic patients |
title_full_unstemmed |
Glycated albumin and its variability as an indicator of cardiovascular autonomic neuropathy development in type 2 diabetic patients |
title_sort |
glycated albumin and its variability as an indicator of cardiovascular autonomic neuropathy development in type 2 diabetic patients |
publisher |
BMC |
series |
Cardiovascular Diabetology |
issn |
1475-2840 |
publishDate |
2017-10-01 |
description |
Abstract Background We investigated whether glycated albumin (GA) and its variability are associated with cardiovascular autonomic neuropathy (CAN) and further compared their associations with glycated hemoglobin (HbA1c). Methods This retrospective longitudinal study included 498 type 2 diabetic patients without CAN. CAN was defined as at least two abnormal results in parasympathetic tests or presence of orthostatic hypotension. The mean, standard deviation (SD), and coefficient of variance (CV) were calculated from consecutively measured GA (median 7 times) and HbA1c levels (median 8 times) over 2 years. Logistic regression analysis was used to compare the associations between CAN and GA- or HbA1c-related parameters. Receiver operating characteristic (ROC) curve analysis was used to compare the predictive power for CAN between GA- and HbA1c-related parameters. Results A total of 53 subjects (10.6%) developed CAN over 2 years. The mean, SD, and CV of GA or HbA1c were significantly higher in subjects with CAN. Higher mean GA and GA variability were associated with the risk of developing CAN, independent of conventional risk factors and HbA1c. In ROC curve analysis, the SD and CV of GA showed higher predictive value for CAN compared to the SD and CV of HbA1c, whereas the predictive value of mean GA did not differ from that of mean HbA1c. The mean, SD, and CV of GA showed additive predictive power to detect CAN development along with mean HbA1c. Conclusions Higher serum GA and its variability are significantly associated with the risk of developing CAN. Serum GA might be a useful indicator for diabetic complications and can enhance HbA1c’s modest clinical prediction for CAN. |
topic |
Glycated albumin Cardiovascular autonomic neuropathy Glycemic variability Type 2 diabetes |
url |
http://link.springer.com/article/10.1186/s12933-017-0619-2 |
work_keys_str_mv |
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