Harmine suppresses hyper-activated Ras–MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans

Harmine suppresses hyper-activated Ras–MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans

Abstract Background Mutationally activated Ras proteins are closely linked to a wide variety of human cancers. Hence, there has been an intensive search for anti-Ras therapies for cancer treatment. The sole Ras gene, which encodes LET-60, in Caenorhabditis elegans regulates vulval development. While...

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Bibliographic Details
Main Authors: Jiaojiao Ji, Jiang Yuan, Xiaoyu Guo, Ruifang Ji, Qinghua Quan, Mei Ding, Xia Li, Yonggang Liu
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Cancer Cell International
Subjects:
Harmine
LET-60/Ras
LIN-45/Raf
MAPK pathway
C. elegans
Online Access:http://link.springer.com/article/10.1186/s12935-019-0880-4

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