Endoplasmic Reticulum Stress in Metabolic Disorders
Metabolic disorders have become among the most serious threats to human health, leading to severe chronic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease, as well as cardiovascular diseases. Interestingly, despite the fact that each of these diseases has different ph...
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doaj-ac899e17e0384ed9bc295c9e4e07b79d2020-11-24T23:08:39ZengMDPI AGCells2073-44092018-06-01766310.3390/cells7060063cells7060063Endoplasmic Reticulum Stress in Metabolic DisordersRose Ghemrawi0Shyue-Fang Battaglia-Hsu1Carole Arnold2College of Pharmacy, Al Ain University of Science and Technology, 112612 Abu Dhabi, UAENutrition Génétique et Exposition aux Risques Environnementaux, INSERM Unité 1256, Université de Lorraine, 54000 Vandoeuvre les Nancy, FranceNutrition Génétique et Exposition aux Risques Environnementaux, INSERM Unité 1256, Université de Lorraine, 54000 Vandoeuvre les Nancy, FranceMetabolic disorders have become among the most serious threats to human health, leading to severe chronic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease, as well as cardiovascular diseases. Interestingly, despite the fact that each of these diseases has different physiological and clinical symptoms, they appear to share certain pathological traits such as intracellular stress and inflammation induced by metabolic disturbance stemmed from over nutrition frequently aggravated by a modern, sedentary life style. These modern ways of living inundate cells and organs with saturating levels of sugar and fat, leading to glycotoxicity and lipotoxicity that induce intracellular stress signaling ranging from oxidative to ER stress response to cope with the metabolic insults (Mukherjee, et al., 2015). In this review, we discuss the roles played by cellular stress and its responses in shaping metabolic disorders. We have summarized here current mechanistic insights explaining the pathogenesis of these disorders. These are followed by a discussion of the latest therapies targeting the stress response pathways.http://www.mdpi.com/2073-4409/7/6/63endoplasmic reticulum stressmetabolic disordersunfolded protein responseinflammationlipotoxicityglucotoxicitytherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rose Ghemrawi Shyue-Fang Battaglia-Hsu Carole Arnold |
spellingShingle |
Rose Ghemrawi Shyue-Fang Battaglia-Hsu Carole Arnold Endoplasmic Reticulum Stress in Metabolic Disorders Cells endoplasmic reticulum stress metabolic disorders unfolded protein response inflammation lipotoxicity glucotoxicity therapy |
author_facet |
Rose Ghemrawi Shyue-Fang Battaglia-Hsu Carole Arnold |
author_sort |
Rose Ghemrawi |
title |
Endoplasmic Reticulum Stress in Metabolic Disorders |
title_short |
Endoplasmic Reticulum Stress in Metabolic Disorders |
title_full |
Endoplasmic Reticulum Stress in Metabolic Disorders |
title_fullStr |
Endoplasmic Reticulum Stress in Metabolic Disorders |
title_full_unstemmed |
Endoplasmic Reticulum Stress in Metabolic Disorders |
title_sort |
endoplasmic reticulum stress in metabolic disorders |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2018-06-01 |
description |
Metabolic disorders have become among the most serious threats to human health, leading to severe chronic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease, as well as cardiovascular diseases. Interestingly, despite the fact that each of these diseases has different physiological and clinical symptoms, they appear to share certain pathological traits such as intracellular stress and inflammation induced by metabolic disturbance stemmed from over nutrition frequently aggravated by a modern, sedentary life style. These modern ways of living inundate cells and organs with saturating levels of sugar and fat, leading to glycotoxicity and lipotoxicity that induce intracellular stress signaling ranging from oxidative to ER stress response to cope with the metabolic insults (Mukherjee, et al., 2015). In this review, we discuss the roles played by cellular stress and its responses in shaping metabolic disorders. We have summarized here current mechanistic insights explaining the pathogenesis of these disorders. These are followed by a discussion of the latest therapies targeting the stress response pathways. |
topic |
endoplasmic reticulum stress metabolic disorders unfolded protein response inflammation lipotoxicity glucotoxicity therapy |
url |
http://www.mdpi.com/2073-4409/7/6/63 |
work_keys_str_mv |
AT roseghemrawi endoplasmicreticulumstressinmetabolicdisorders AT shyuefangbattagliahsu endoplasmicreticulumstressinmetabolicdisorders AT carolearnold endoplasmicreticulumstressinmetabolicdisorders |
_version_ |
1725613134947811328 |