Healthy Aging and Dementia: Two Roads Diverging in Midlife?
Dementia, particularly Alzheimer’s disease (AD), is a growing pandemic that presents profound challenges to healthcare systems, families, and societies throughout the world. By 2050, the number of people living with dementia worldwide could almost triple, from 47 to 132 million, with associated cost...
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2018-09-01
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doaj-ac8a0fe365d04631aed1907b4f9f98c22020-11-24T22:19:34ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652018-09-011010.3389/fnagi.2018.00275412313Healthy Aging and Dementia: Two Roads Diverging in Midlife?Katie Irwin0Claire Sexton1Claire Sexton2Tarun Daniel3Brian Lawlor4Brian Lawlor5Lorina Naci6Lorina Naci7Department of Neuroscience, University of Georgia, Athens, GA, United StatesMemory and Aging Center, Global Brain Health Institute, University of California, San Francisco, San Francisco, CA, United StatesOxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Oxford, United KingdomDepartment of Neuroscience, University of Georgia, Athens, GA, United StatesMercer’s Institute for Successful Ageing, St. James’s Hospital, Dublin, IrelandThe Global Brain Health Institute, Trinity College Dublin, Dublin, IrelandThe Global Brain Health Institute, Trinity College Dublin, Dublin, IrelandSchool of Psychology, Trinity College Dublin, Dublin, IrelandDementia, particularly Alzheimer’s disease (AD), is a growing pandemic that presents profound challenges to healthcare systems, families, and societies throughout the world. By 2050, the number of people living with dementia worldwide could almost triple, from 47 to 132 million, with associated costs rising to $3 trillion. To reduce the future incidence of dementia, there is an immediate need for interventions that target the disease process from its earliest stages. Research programs are increasingly starting to focus on midlife as a critical period for the beginning of AD-related pathology, yet the indicators of the incipient disease process in asymptomatic individuals remain poorly understood. We address this important knowledge gap by examining evidence for cognitive and structural brain changes that may differentiate, from midlife, healthy aging and pathological AD-related processes. This review crystallizes emerging trends for divergence between the two and highlights current limitations and opportunities for future research in this area.https://www.frontiersin.org/article/10.3389/fnagi.2018.00275/fullagingearly markersmidlifeAlzheimer’s diseasedementiacognition and brain structure |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Katie Irwin Claire Sexton Claire Sexton Tarun Daniel Brian Lawlor Brian Lawlor Lorina Naci Lorina Naci |
spellingShingle |
Katie Irwin Claire Sexton Claire Sexton Tarun Daniel Brian Lawlor Brian Lawlor Lorina Naci Lorina Naci Healthy Aging and Dementia: Two Roads Diverging in Midlife? Frontiers in Aging Neuroscience aging early markers midlife Alzheimer’s disease dementia cognition and brain structure |
author_facet |
Katie Irwin Claire Sexton Claire Sexton Tarun Daniel Brian Lawlor Brian Lawlor Lorina Naci Lorina Naci |
author_sort |
Katie Irwin |
title |
Healthy Aging and Dementia: Two Roads Diverging in Midlife? |
title_short |
Healthy Aging and Dementia: Two Roads Diverging in Midlife? |
title_full |
Healthy Aging and Dementia: Two Roads Diverging in Midlife? |
title_fullStr |
Healthy Aging and Dementia: Two Roads Diverging in Midlife? |
title_full_unstemmed |
Healthy Aging and Dementia: Two Roads Diverging in Midlife? |
title_sort |
healthy aging and dementia: two roads diverging in midlife? |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2018-09-01 |
description |
Dementia, particularly Alzheimer’s disease (AD), is a growing pandemic that presents profound challenges to healthcare systems, families, and societies throughout the world. By 2050, the number of people living with dementia worldwide could almost triple, from 47 to 132 million, with associated costs rising to $3 trillion. To reduce the future incidence of dementia, there is an immediate need for interventions that target the disease process from its earliest stages. Research programs are increasingly starting to focus on midlife as a critical period for the beginning of AD-related pathology, yet the indicators of the incipient disease process in asymptomatic individuals remain poorly understood. We address this important knowledge gap by examining evidence for cognitive and structural brain changes that may differentiate, from midlife, healthy aging and pathological AD-related processes. This review crystallizes emerging trends for divergence between the two and highlights current limitations and opportunities for future research in this area. |
topic |
aging early markers midlife Alzheimer’s disease dementia cognition and brain structure |
url |
https://www.frontiersin.org/article/10.3389/fnagi.2018.00275/full |
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