Multiple specialized stem cell niches characterize hematopoiesis in the human fetal liver
Before birth, different organs retain hematopoiesis. The liver is involved in the 6th-8th week of gestation. The hepatic hematopoietic stem cell (HSC) niche begins when HSCs colonize the liver and make contact with sinusoidal endothelial cells. The aim of this study is to characterize the developmen...
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Hygeia Press di Corridori Marinella
2020-02-01
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doaj-ac91fb95819947b3aee6544b1f6d06212020-11-25T03:34:25ZengHygeia Press di Corridori MarinellaJournal of Pediatric and Neonatal Individualized Medicine2281-06922020-02-0191e090118e09011810.7363/090118619Multiple specialized stem cell niches characterize hematopoiesis in the human fetal liverDaniela Fanni0Francesco Angotzi1Clara Gerosa2Doris Barcellona3Giancarlo Senes4Federica Lai5Giovanni Martino6Stefano Ascani7Vassilios Fanos8Gavino Faa9Department of Pathology, University of Cagliari, “S. Giovanni di Dio” University Hospital, Cagliari, ItalyDepartment of Pathology, University of Cagliari, “S. Giovanni di Dio” University Hospital, Cagliari, ItalyDepartment of Pathology, University of Cagliari, “S. Giovanni di Dio” University Hospital, Cagliari, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, ItalyDepartment of Pathology, University of Cagliari, “S. Giovanni di Dio” University Hospital, Cagliari, ItalyDepartment of Pathology, University of Cagliari, “S. Giovanni di Dio” University Hospital, Cagliari, ItalyHematology and Clinical Immunology, University of Perugia, Perugia, ItalyInstitute of Pathology, Azienda Ospedaliera S. Maria Terni, University of Perugia, Perugia, ItalyNeonatal Intensive Care Unit, University of Cagliari, Cagliari, ItalyDepartment of Pathology, University of Cagliari, “S. Giovanni di Dio” University Hospital, Cagliari, ItalyBefore birth, different organs retain hematopoiesis. The liver is involved in the 6th-8th week of gestation. The hepatic hematopoietic stem cell (HSC) niche begins when HSCs colonize the liver and make contact with sinusoidal endothelial cells. The aim of this study is to characterize the development of each hematopoietic cell lineage in 9 human liver specimens between 10 and 29 weeks of gestation with immunohistochemistry. Hematopoietic activity was coherent with gestational age. Erythropoiesis was the greatest fraction of fetal liver hematopoiesis: myeloid/erythroid ratio was inverted compared to the adult bone marrow. Myelopoiesis was compartmentalized in the periportal zone. Factor-VIII-positive cells were small, with a megakaryoblast-like morphology. Lymphoid precursors were absent. A small quantity of T and B lymphocytes was found. CD34-reactive hematopoietic stem and progenitor cells were found in a minority of cells. The understanding of the hematopoietic process during gestation could in the future contribute to better understand child and adult hematologic conditions.https://www.jpnim.com/index.php/jpnim/article/view/736liverstem cell nicheshepatic hematopoiesishumanerythropoiesismyelopoiesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniela Fanni Francesco Angotzi Clara Gerosa Doris Barcellona Giancarlo Senes Federica Lai Giovanni Martino Stefano Ascani Vassilios Fanos Gavino Faa |
spellingShingle |
Daniela Fanni Francesco Angotzi Clara Gerosa Doris Barcellona Giancarlo Senes Federica Lai Giovanni Martino Stefano Ascani Vassilios Fanos Gavino Faa Multiple specialized stem cell niches characterize hematopoiesis in the human fetal liver Journal of Pediatric and Neonatal Individualized Medicine liver stem cell niches hepatic hematopoiesis human erythropoiesis myelopoiesis |
author_facet |
Daniela Fanni Francesco Angotzi Clara Gerosa Doris Barcellona Giancarlo Senes Federica Lai Giovanni Martino Stefano Ascani Vassilios Fanos Gavino Faa |
author_sort |
Daniela Fanni |
title |
Multiple specialized stem cell niches characterize hematopoiesis in the human fetal liver |
title_short |
Multiple specialized stem cell niches characterize hematopoiesis in the human fetal liver |
title_full |
Multiple specialized stem cell niches characterize hematopoiesis in the human fetal liver |
title_fullStr |
Multiple specialized stem cell niches characterize hematopoiesis in the human fetal liver |
title_full_unstemmed |
Multiple specialized stem cell niches characterize hematopoiesis in the human fetal liver |
title_sort |
multiple specialized stem cell niches characterize hematopoiesis in the human fetal liver |
publisher |
Hygeia Press di Corridori Marinella |
series |
Journal of Pediatric and Neonatal Individualized Medicine |
issn |
2281-0692 |
publishDate |
2020-02-01 |
description |
Before birth, different organs retain hematopoiesis. The liver is involved in the 6th-8th week of gestation. The hepatic hematopoietic stem cell (HSC) niche begins when HSCs colonize the liver and make contact with sinusoidal endothelial cells. The aim of this study is to characterize the development of each hematopoietic cell lineage in 9 human liver specimens between 10 and 29 weeks of gestation with immunohistochemistry. Hematopoietic activity was coherent with gestational age. Erythropoiesis was the greatest fraction of fetal liver hematopoiesis: myeloid/erythroid ratio was inverted compared to the adult bone marrow. Myelopoiesis was compartmentalized in the periportal zone. Factor-VIII-positive cells were small, with a megakaryoblast-like morphology. Lymphoid precursors were absent. A small quantity of T and B lymphocytes was found. CD34-reactive hematopoietic stem and progenitor cells were found in a minority of cells. The understanding of the hematopoietic process during gestation could in the future contribute to better understand child and adult hematologic conditions. |
topic |
liver stem cell niches hepatic hematopoiesis human erythropoiesis myelopoiesis |
url |
https://www.jpnim.com/index.php/jpnim/article/view/736 |
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