Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer’s disease

Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer’s disease

Abstract Sustained brain chronic inflammation in Alzheimer’s disease (AD) includes glial cell activation, an increase in cytokines and chemokines, and lipid mediators (LMs), concomitant with decreased pro-homeostatic mediators. The inflammatory response at the onset of pathology engages activation o...

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Bibliographic Details
Main Authors: Ceren Emre, Khanh V. Do, Bokkyoo Jun, Erik Hjorth, Silvia Gómez Alcalde, Marie-Audrey I. Kautzmann, William C. Gordon, Per Nilsson, Nicolas G. Bazan, Marianne Schultzberg
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer
Amyloid
Astrocyte
Inflammation
Lipid mediators
Microglia
Online Access:https://doi.org/10.1186/s40478-021-01216-4

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