Expression and significance of transforming growth factor β-activated kinase 1 in uterine myoma tissue
Objective: To compare the expression of TAK1 in normal myometrium and uterine leiomyoma tissue, and explore the relationship between these molecules and pathogenesis of uterine leiomyoma. Methods: Formaldehyde-fixed, paraffin-embedded specimen from 76 patients with uterine leiomyoma and normal my...
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doaj-ac97649d725e47f092ea7c50723c721f2020-11-24T22:30:07ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372016-03-012267072Expression and significance of transforming growth factor β-activated kinase 1 in uterine myoma tissueXiao-Ping Chen0Li Zhao1Department of Obstetrics and Gynecology, Xi'an Sports Trauma Hospital, Xi'an 710068,Shaanxi Province, ChinaDepartment of Obstetrics and Gynecology, Xi'an Sports Trauma Hospital, Xi'an 710068,Shaanxi Province, ChinaObjective: To compare the expression of TAK1 in normal myometrium and uterine leiomyoma tissue, and explore the relationship between these molecules and pathogenesis of uterine leiomyoma. Methods: Formaldehyde-fixed, paraffin-embedded specimen from 76 patients with uterine leiomyoma and normal myometrium adjacent were obtained from our hospital. The expression of TAK1 was detected by immunohistochemical staining and PCR analysis. Results: The expression of protein and mRNA levels TAK1 in uterine leiomyoma tissues were significantly increased when compared with normal myometrium, but not related to the number of leiomyoma. Furthermore, TAK1 expression was associated with the size of uterine leiomyoma. Conclusion: The present results suggest that the abundant expression of TAK1 protein may have a molecular basis characteristic of leiomyomas in the human uterus, and TAK1 may be a therapeutic target for the treatment of uterine leiomyoma.http://www.jhmuweb.net/PDF/201606/20.pdfUterine leiomyomaTAK1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiao-Ping Chen Li Zhao |
spellingShingle |
Xiao-Ping Chen Li Zhao Expression and significance of transforming growth factor β-activated kinase 1 in uterine myoma tissue Journal of Hainan Medical University Uterine leiomyoma TAK1 |
author_facet |
Xiao-Ping Chen Li Zhao |
author_sort |
Xiao-Ping Chen |
title |
Expression and significance of transforming growth factor β-activated kinase 1 in uterine myoma tissue |
title_short |
Expression and significance of transforming growth factor β-activated kinase 1 in uterine myoma tissue |
title_full |
Expression and significance of transforming growth factor β-activated kinase 1 in uterine myoma tissue |
title_fullStr |
Expression and significance of transforming growth factor β-activated kinase 1 in uterine myoma tissue |
title_full_unstemmed |
Expression and significance of transforming growth factor β-activated kinase 1 in uterine myoma tissue |
title_sort |
expression and significance of transforming growth factor β-activated kinase 1 in uterine myoma tissue |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2016-03-01 |
description |
Objective: To compare the expression of TAK1 in normal myometrium and uterine leiomyoma
tissue, and explore the relationship between these molecules and pathogenesis of uterine
leiomyoma. Methods: Formaldehyde-fixed, paraffin-embedded specimen from 76 patients
with uterine leiomyoma and normal myometrium adjacent were obtained from our hospital.
The expression of TAK1 was detected by immunohistochemical staining and PCR analysis.
Results: The expression of protein and mRNA levels TAK1 in uterine leiomyoma tissues
were significantly increased when compared with normal myometrium, but not related to the
number of leiomyoma. Furthermore, TAK1 expression was associated with the size of uterine
leiomyoma. Conclusion: The present results suggest that the abundant expression of TAK1
protein may have a molecular basis characteristic of leiomyomas in the human uterus, and
TAK1 may be a therapeutic target for the treatment of uterine leiomyoma. |
topic |
Uterine leiomyoma TAK1 |
url |
http://www.jhmuweb.net/PDF/201606/20.pdf |
work_keys_str_mv |
AT xiaopingchen expressionandsignificanceoftransforminggrowthfactorbactivatedkinase1inuterinemyomatissue AT lizhao expressionandsignificanceoftransforminggrowthfactorbactivatedkinase1inuterinemyomatissue |
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