Indolent T-Cell Lymphoproliferative Disorders of the Gastrointestinal Tract (iTLPD-GI): A Review

• Main Authors: Francesca Sanguedolce, Magda Zanelli, Maurizio Zizzo, Stefano Luminari, Giovanni Martino, Alessandra Soriano, Linda Ricci, Cecilia Caprera, Stefano Ascani
• Format: Article
• Language: English
• Published: MDPI AG 2021-06-01
• Series: Cancers
• Subjects: indolent T-cell lymphoproliferative disorder of the gastro-intestinal tract (iTLPD-GI); diagnosis; immunohistochemistry
• Online Access: https://www.mdpi.com/2072-6694/13/11/2790

iTLPD-GI is a low-grade clonal T-cell lymphoproliferative disease arising in GI organs. It is an uncommon disease, and only recently has it been enlisted as a distinct provisional entity in the current WHO Classification. Data from the literature disclose high heterogeneity in terms of pathological and molecular features; on the other hand, establishing an accurate diagnosis of iTLPD-GI is of pivotal importance, since treatment options are different from that of other, more frequent lymphomas that arise in the gastrointestinal tract. In this review, we aimed to better define this novel entity, and to identify useful diagnostic biomarkers; moreover, we provide a biomarker-based approach to the diagnosis and describe the most common issues in differentiating iTLPD-GI from other neoplastic and non-neoplastic disorders.