Immunotherapy against Systemic Fungal Infections Based on Monoclonal Antibodies
<b>: </b>The increasing incidence in systemic fungal infections in humans has increased focus for the development of fungal vaccines and use of monoclonal antibodies. Invasive mycoses are generally difficult to treat, as most occur in vulnerable individuals, with compromised innate and a...
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doaj-acbb597e8725477ea86674de7d2e24522020-11-25T02:15:06ZengMDPI AGJournal of Fungi2309-608X2020-02-01613110.3390/jof6010031jof6010031Immunotherapy against Systemic Fungal Infections Based on Monoclonal AntibodiesCamila Boniche0Suélen Andreia Rossi1Brenda Kischkel2Filipe Vieira Barbalho3Ágata Nogueira D’Aurea Moura4Joshua D. Nosanchuk5Luiz R. Travassos6Carlos Pelleschi Taborda7Biomedical Sciences Institute, Department of Microbiology, University of São Paulo, Sao Paulo 05508-000, BrazilBiomedical Sciences Institute, Department of Microbiology, University of São Paulo, Sao Paulo 05508-000, BrazilBiomedical Sciences Institute, Department of Microbiology, University of São Paulo, Sao Paulo 05508-000, BrazilBiomedical Sciences Institute, Department of Microbiology, University of São Paulo, Sao Paulo 05508-000, BrazilTropical Medicine Institute, Department of Dermatology, Faculty of Medicine, University of Sao Paulo, Sao Paulo 05403-000, BrazilDepartments of Medicine (Division of Infectious Diseases) and Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USADepartment of Microbiology, Immunology and Parasitology, Federal University of São Paulo, Sao Paulo 04021-001, BrazilBiomedical Sciences Institute, Department of Microbiology, University of São Paulo, Sao Paulo 05508-000, Brazil<b>: </b>The increasing incidence in systemic fungal infections in humans has increased focus for the development of fungal vaccines and use of monoclonal antibodies. Invasive mycoses are generally difficult to treat, as most occur in vulnerable individuals, with compromised innate and adaptive immune responses. Mortality rates in the setting of our current antifungal drugs remain excessively high. Moreover, systemic mycoses require prolonged durations of antifungal treatment and side effects frequently occur, particularly drug-induced liver and/or kidney injury. The use of monoclonal antibodies with or without concomitant administration of antifungal drugs emerges as a potentially efficient treatment modality to improve outcomes and reduce chemotherapy toxicities. In this review, we focus on the use of monoclonal antibodies with experimental evidence on the reduction of fungal burden and prolongation of survival in in vivo<i> </i>disease models. Presently, there are no licensed monoclonal antibodies for use in the treatment of systemic mycoses, although the potential of such a vaccine is very high as indicated by the substantial promising results from several experimental models.https://www.mdpi.com/2309-608X/6/1/31therapeutic vaccinesmonoclonal antibodiessystemic fungal infectionsimmunotherapyantifungal vaccinespassive immunization |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Camila Boniche Suélen Andreia Rossi Brenda Kischkel Filipe Vieira Barbalho Ágata Nogueira D’Aurea Moura Joshua D. Nosanchuk Luiz R. Travassos Carlos Pelleschi Taborda |
spellingShingle |
Camila Boniche Suélen Andreia Rossi Brenda Kischkel Filipe Vieira Barbalho Ágata Nogueira D’Aurea Moura Joshua D. Nosanchuk Luiz R. Travassos Carlos Pelleschi Taborda Immunotherapy against Systemic Fungal Infections Based on Monoclonal Antibodies Journal of Fungi therapeutic vaccines monoclonal antibodies systemic fungal infections immunotherapy antifungal vaccines passive immunization |
author_facet |
Camila Boniche Suélen Andreia Rossi Brenda Kischkel Filipe Vieira Barbalho Ágata Nogueira D’Aurea Moura Joshua D. Nosanchuk Luiz R. Travassos Carlos Pelleschi Taborda |
author_sort |
Camila Boniche |
title |
Immunotherapy against Systemic Fungal Infections Based on Monoclonal Antibodies |
title_short |
Immunotherapy against Systemic Fungal Infections Based on Monoclonal Antibodies |
title_full |
Immunotherapy against Systemic Fungal Infections Based on Monoclonal Antibodies |
title_fullStr |
Immunotherapy against Systemic Fungal Infections Based on Monoclonal Antibodies |
title_full_unstemmed |
Immunotherapy against Systemic Fungal Infections Based on Monoclonal Antibodies |
title_sort |
immunotherapy against systemic fungal infections based on monoclonal antibodies |
publisher |
MDPI AG |
series |
Journal of Fungi |
issn |
2309-608X |
publishDate |
2020-02-01 |
description |
<b>: </b>The increasing incidence in systemic fungal infections in humans has increased focus for the development of fungal vaccines and use of monoclonal antibodies. Invasive mycoses are generally difficult to treat, as most occur in vulnerable individuals, with compromised innate and adaptive immune responses. Mortality rates in the setting of our current antifungal drugs remain excessively high. Moreover, systemic mycoses require prolonged durations of antifungal treatment and side effects frequently occur, particularly drug-induced liver and/or kidney injury. The use of monoclonal antibodies with or without concomitant administration of antifungal drugs emerges as a potentially efficient treatment modality to improve outcomes and reduce chemotherapy toxicities. In this review, we focus on the use of monoclonal antibodies with experimental evidence on the reduction of fungal burden and prolongation of survival in in vivo<i> </i>disease models. Presently, there are no licensed monoclonal antibodies for use in the treatment of systemic mycoses, although the potential of such a vaccine is very high as indicated by the substantial promising results from several experimental models. |
topic |
therapeutic vaccines monoclonal antibodies systemic fungal infections immunotherapy antifungal vaccines passive immunization |
url |
https://www.mdpi.com/2309-608X/6/1/31 |
work_keys_str_mv |
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