Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease: Effects on Diadochokinetic Rate
The hypokinetic dysarthria observed in Parkinson's disease (PD) affects the range, speed, and accuracy of articulatory gestures in patients, reducing the perceived quality of speech acoustic output in continuous speech. Deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) and of th...
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Online Access: | http://dx.doi.org/10.4061/2011/605607 |
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doaj-acbd29288f824edcaefa077a52ab169f2020-11-24T23:23:02ZengHindawi LimitedParkinson's Disease2042-00802011-01-01201110.4061/2011/605607605607Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease: Effects on Diadochokinetic RateFredrik Karlsson0Elin Unger1Sofia Wahlgren2Patric Blomstedt3Jan Linder4Erik Nordh5Hamayun Zafar6Jan van Doorn7Division of Speech and Language Pathology, Department of Clinical Sciences, Umeå University, SE-90185 Umeå, SwedenDivision of Speech and Language Pathology, Department of Clinical Sciences, Umeå University, SE-90185 Umeå, SwedenDivision of Speech and Language Pathology, Department of Clinical Sciences, Umeå University, SE-90185 Umeå, SwedenDivision of Clinical Neuroscience, Department of Pharmacology and Clinical Neuroscience, Umeå University, SE-90185 Umeå, SwedenDivision of Clinical Neuroscience, Department of Pharmacology and Clinical Neuroscience, Umeå University, SE-90185 Umeå, SwedenDivision of Clinical Neuroscience, Department of Pharmacology and Clinical Neuroscience, Umeå University, SE-90185 Umeå, SwedenRehabilitation Research Chair, King Saud University, Riyadh 11433, Saudi ArabiaDivision of Speech and Language Pathology, Department of Clinical Sciences, Umeå University, SE-90185 Umeå, SwedenThe hypokinetic dysarthria observed in Parkinson's disease (PD) affects the range, speed, and accuracy of articulatory gestures in patients, reducing the perceived quality of speech acoustic output in continuous speech. Deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) and of the caudal zona incerta (cZi-DBS) are current surgical treatment options for PD. This study aimed at investigating the outcome of STN-DBS (7 patients) and cZi-DBS (7 patients) in two articulatory diadochokinesis tasks (AMR and SMR) using measurements of articulation rate and quality of the plosive consonants (using the percent measurable VOT metric). The results indicate that patients receiving STN-DBS increased in articulation rate in the Stim-ON condition in the AMR task only, with no effect on production quality. Patients receiving cZi-DBS decreased in articulation rate in the Stim-ON condition and further showed a reduction in production quality. The data therefore suggest that cZi-DBS is more detrimental for extended articulatory movements than STN-DBS.http://dx.doi.org/10.4061/2011/605607 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fredrik Karlsson Elin Unger Sofia Wahlgren Patric Blomstedt Jan Linder Erik Nordh Hamayun Zafar Jan van Doorn |
spellingShingle |
Fredrik Karlsson Elin Unger Sofia Wahlgren Patric Blomstedt Jan Linder Erik Nordh Hamayun Zafar Jan van Doorn Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease: Effects on Diadochokinetic Rate Parkinson's Disease |
author_facet |
Fredrik Karlsson Elin Unger Sofia Wahlgren Patric Blomstedt Jan Linder Erik Nordh Hamayun Zafar Jan van Doorn |
author_sort |
Fredrik Karlsson |
title |
Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease: Effects on Diadochokinetic Rate |
title_short |
Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease: Effects on Diadochokinetic Rate |
title_full |
Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease: Effects on Diadochokinetic Rate |
title_fullStr |
Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease: Effects on Diadochokinetic Rate |
title_full_unstemmed |
Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease: Effects on Diadochokinetic Rate |
title_sort |
deep brain stimulation of caudal zona incerta and subthalamic nucleus in patients with parkinson's disease: effects on diadochokinetic rate |
publisher |
Hindawi Limited |
series |
Parkinson's Disease |
issn |
2042-0080 |
publishDate |
2011-01-01 |
description |
The hypokinetic dysarthria observed in Parkinson's disease (PD) affects the range, speed, and accuracy of articulatory gestures in patients, reducing the perceived quality of speech acoustic output in continuous speech. Deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) and of the caudal zona incerta (cZi-DBS) are current surgical treatment options for PD. This study aimed at investigating the outcome of STN-DBS (7 patients) and cZi-DBS (7 patients) in two articulatory diadochokinesis tasks (AMR and SMR) using measurements of articulation rate and quality of the plosive consonants (using the percent measurable VOT metric). The results indicate that patients receiving STN-DBS increased in articulation rate in the Stim-ON condition in the AMR task only, with no effect on production quality. Patients receiving cZi-DBS decreased in articulation rate in the Stim-ON condition and further showed a reduction in production quality. The data therefore suggest that cZi-DBS is more detrimental for extended articulatory movements than STN-DBS. |
url |
http://dx.doi.org/10.4061/2011/605607 |
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