Study on safety of laparoscopic total gastrectomy for clinical stage I gastric cancer: the protocol of the CLASS02–01 multicenter randomized controlled clinical trial

• Main Authors: Hongyong He, Haojie Li, Xiangqian Su, Ziyu Li, Peiwu Yu, Hua Huang, Changming Huang, Jianxin Ye, Yong Li, Jian Suo, Jiren Yu, Guoxin Li, Zekuan Xu, Gang Zhao, Hui Cao, Jiankun Hu, Xiaohui Du, Fenglin Liu, Yihong Sun, on behalf of the Chinese Laparoscopic Gastrointestinal Surgery Study (CLASS) Group
• Format: Article
• Language: English
• Published: BMC 2018-10-01
• Series: BMC Cancer
• Subjects: Gastric cancer; Laparoscopic total gastrectomy; Safety; Randomized controlled trial
• Online Access: http://link.springer.com/article/10.1186/s12885-018-4846-z

Abstract Background The safety of laparoscopic total gastrectomy (LTG) for the treatment of gastric cancer remains lack of clinical evidence. The Chinese Laparoscopic Gastrointestinal Surgery Study (CLASS) Group recently launched a multicenter randomized clinical trial (CLASS02–01) to compare the safety of LTG for clinical stage I gastric cancer with the conventional open total gastrectomy (OTG). Methods This CLASS02–01 trial is a prospective, multicenter, randomized, controlled, open, and non-inferiority trial. Two hundred patients who met the inclusion criteria and did not accord with the exclusion criteria will be randomly divided into LTG group (n = 100) and OTG group (n = 100). The primary purpose of this study is to evaluate the early operative morbidity and mortality of LTG compared with OTG for clinical stage I gastric adenocarcinoma. The second purpose is to evaluate the recovery course and compare the postoperative hospital stay of the patients enrolled in this study. Discussion This CLASS02–01 trial is the first prospective randomized two-arm controlled study to determine the safety of LTG compared with OTG. Through this trial, we hope to show that experienced surgeons can safely perform LTG with lymphadenectomy for gastric cancer. Trial registration ClinicalTrials.gov ID: NCT03007550. December 30, 2016.