Implication of heme oxygenase-1 in the sensitivity of nasopharyngeal carcinomas to radiotherapy
<p>Abstract</p> <p>High expression of the inducible isoform of heme oxygenase (HO-1) is well known in various solid tumors in human and experimental animal models. To investigate the relationship between HO-1 and nasopharyngeal carcinomas, especially its involvement in the response...
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doaj-acc078be6145473e9f0e9fe28dadf2972020-11-24T22:16:23ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662008-06-012711310.1186/1756-9966-27-13Implication of heme oxygenase-1 in the sensitivity of nasopharyngeal carcinomas to radiotherapyFang JunShi Lei<p>Abstract</p> <p>High expression of the inducible isoform of heme oxygenase (HO-1) is well known in various solid tumors in human and experimental animal models. To investigate the relationship between HO-1 and nasopharyngeal carcinomas, especially its involvement in the response of nasopharyngeal carcinomas to radiotherapy, thirty-two nasopharyngeal carcinomas were semi-quantitatively analyzed by RT-PCR, and the expression of HO-1 was correlated with the consequence after novel radiotherapy, which was evaluated by the reduction of tumor size. Among 32 nasopharyngeal carcinomas, HO-1 expression was found in19 samples (59.4%), in which 9 patients (47.4%) showed no response to radiotherapy. Interestingly, in 13 nasopharyngeal carcinoma patients with negative expression of HO-1, radiotherapy exhibited to be effective (9 patients, 69.2%) or responsive (3 patients, 23.1%). In this study, we first demonstrated the expression of HO-1 in nasopharyngeal carcinomas, and more important, these findings strongly suggest the potential of HO-1as a useful index in identifying patients with well response to radiotherapy, further these data indicate a new therapeutic for nasopharyngeal carcinoma by inhibiting HO-1 activity, which warrants further investigation.</p> http://www.jeccr.com/content/27/1/13 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fang Jun Shi Lei |
spellingShingle |
Fang Jun Shi Lei Implication of heme oxygenase-1 in the sensitivity of nasopharyngeal carcinomas to radiotherapy Journal of Experimental & Clinical Cancer Research |
author_facet |
Fang Jun Shi Lei |
author_sort |
Fang Jun |
title |
Implication of heme oxygenase-1 in the sensitivity of nasopharyngeal carcinomas to radiotherapy |
title_short |
Implication of heme oxygenase-1 in the sensitivity of nasopharyngeal carcinomas to radiotherapy |
title_full |
Implication of heme oxygenase-1 in the sensitivity of nasopharyngeal carcinomas to radiotherapy |
title_fullStr |
Implication of heme oxygenase-1 in the sensitivity of nasopharyngeal carcinomas to radiotherapy |
title_full_unstemmed |
Implication of heme oxygenase-1 in the sensitivity of nasopharyngeal carcinomas to radiotherapy |
title_sort |
implication of heme oxygenase-1 in the sensitivity of nasopharyngeal carcinomas to radiotherapy |
publisher |
BMC |
series |
Journal of Experimental & Clinical Cancer Research |
issn |
1756-9966 |
publishDate |
2008-06-01 |
description |
<p>Abstract</p> <p>High expression of the inducible isoform of heme oxygenase (HO-1) is well known in various solid tumors in human and experimental animal models. To investigate the relationship between HO-1 and nasopharyngeal carcinomas, especially its involvement in the response of nasopharyngeal carcinomas to radiotherapy, thirty-two nasopharyngeal carcinomas were semi-quantitatively analyzed by RT-PCR, and the expression of HO-1 was correlated with the consequence after novel radiotherapy, which was evaluated by the reduction of tumor size. Among 32 nasopharyngeal carcinomas, HO-1 expression was found in19 samples (59.4%), in which 9 patients (47.4%) showed no response to radiotherapy. Interestingly, in 13 nasopharyngeal carcinoma patients with negative expression of HO-1, radiotherapy exhibited to be effective (9 patients, 69.2%) or responsive (3 patients, 23.1%). In this study, we first demonstrated the expression of HO-1 in nasopharyngeal carcinomas, and more important, these findings strongly suggest the potential of HO-1as a useful index in identifying patients with well response to radiotherapy, further these data indicate a new therapeutic for nasopharyngeal carcinoma by inhibiting HO-1 activity, which warrants further investigation.</p> |
url |
http://www.jeccr.com/content/27/1/13 |
work_keys_str_mv |
AT fangjun implicationofhemeoxygenase1inthesensitivityofnasopharyngealcarcinomastoradiotherapy AT shilei implicationofhemeoxygenase1inthesensitivityofnasopharyngealcarcinomastoradiotherapy |
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1725790186181230592 |