HMGB1 in severe soft tissue infections caused by Streptococcus pyogenes

HMGB1 in severe soft tissue infections caused by Streptococcus pyogenes

Extracellular High Mobility Group Box 1 (HMGB1) has been associated with acute and chronic inflammatory conditions. However, little is known about HMGB1 in necrotizing bacterial infections. We hypothesized that the local HMGB1 response is excessive in severe soft tissue infections, which are charact...

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Bibliographic Details
Main Authors: Linda eJohansson, Johanna eSnäll, Parham eSendi, Anna eLinnér, Pontus eThulin, Adam eLinder, Carl-Johan eTreutiger, Anna eNorrby-Teglund
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Inflammation
Necrosis
Soft Tissue Infections
Streptococcus pyogenes
HMGB1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00004/full

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