Genetically elevated high‐density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease
Abstract Introduction There is conflicting evidence whether high‐density lipoprotein cholesterol (HDL‐C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (CETP) locus is associated with altered HDL‐C. We aimed to assess AD r...
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Format: | Article |
Language: | English |
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Wiley
2018-01-01
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Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
Subjects: | |
Online Access: | https://doi.org/10.1016/j.dadm.2018.08.008 |
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Gina M. Peloso Sven J. van derLee International Genomics of Alzheimer's Project (IGAP) R. Sims S.J. van derLee A.C. Naj C. Bellenguez N. Badarinarayan J. Jakobsdottir B.W. Kunkle A. Boland R. Raybould J.C. Bis E.R. Martin B. Grenier‐Boley S. Heilmann‐Heimbach V. Chouraki A.B. Kuzma K. Sleegers M. Vronskaya A. Ruiz R.R. Graham R. Olaso P. Hoffmann M.L. Grove B.N. Vardarajan M. Hiltunen M.M. Nöthen C.C. White K.L. Hamilton‐Nelson J. Epelbaum W. Maier S.H. Choi G.W. Beecham C. Dulary S. Herms A.V. Smith C.C. Funk Derbois A.J. Forstner S. Ahmad H. Li D. Bacq D. Harold C.L. Satizabal O. Valladares A. Squassina R. Thomas J.A. Brody L. Qu P. Sánchez‐Juan T. Morgan F.J. Wolters Y. Zhao F.S. Garcia N. Denning M. Fornage J. Malamon M.C.D. Naranjo E. Majounie T.H. Mosley B. Dombroski D. Wallon M.K. Lupton J. Dupuis P. Whitehead L. Fratiglioni C. Medway X. Jian S. Mukherjee L. Keller K. Brown H. Lin L.B. Cantwell F. Panza B. McGuinness S. Moreno‐Grau J.D. Burgess V. Solfrizzi P. Proitsi H.H. Adams M. Allen D. Seripa P. Pastor L.A. Cupples N.D. Price D. Hannequin A. Frank‐García D. Levy P. Chakrabarty P. Caffarra I. Giegling A.S. Beiser V. Giedraitis H. Hampel M.E. Garcia X. Wang L. Lannfelt P. Mecocci G. Eiriksdottir P.K. Crane F. Pasquier V. Boccardi I. Henández R.C. Barber M. Scherer L. Tarraga P.M. Adams M. Leber Y. Chen M.S. Albert S. Riedel‐Heller V. Emilsson D. Beekly A. Braae R. Schmidt D. Blacker C. Masullo H. Schmidt R.S. Doody G. Spalletta W.T. Longstreth Jr. T.J. Fairchild P. Bossù O.L. Lopez M.P. Frosch E. Sacchinelli B. Ghetti Q. Yang R.M. Huebinger F. Jessen S. Li M.I. Kamboh J. Morris O. Sotolongo‐Grau M.J. Katz C. Corcoran M. Dunstan A. Braddel C. Thomas A. Meggy R. Marshall A. Gerrish J. Chapman M. Aguilar S. Taylor M. Hill M.D. Fairén A. Hodges B. Vellas H. Soininen I. Kloszewska M. Daniilidou J. Uphill Y. Patel J.T. Hughes J. Lord J. Turton A.M. Hartmann R. Cecchetti C. Fenoglio M. Serpente M. Arcaro C. Caltagirone M.D. Orfei A. Ciaramella S. Pichler M. Mayhaus W. Gu A. Lleó J. Fortea R. Blesa I.S. Barber K. Brookes C. Cupidi R.G. Maletta D. Carrell S. Sorbi S. Moebus M. Urbano A. Pilotto J. Kornhuber P. Bosco S. Todd D. Craig J. Johnston M. Gill B. Lawlor A. Lynch N.C. Fox J. Hardy ARUK Consortium R.L. Albin L.G. Apostolova S.E. Arnold S. Asthana C.S. Atwood C.T. Baldwin L.L. Barnes S. Barral T.G. Beach J.T. Becker E.H. Bigio T.D. Bird B.F. Boeve J.D. Bowen A. Boxer J.R. Burke J.M. Burns J.D. Buxbaum N.J. Cairns C. Cao C.S. Carlson C.M. Carlsson R.M. Carney M.M. Carrasquillo S.L. Carroll C.C. Diaz H.C. Chui D.G. Clark D.H. Cribbs E.A. Crocco C. DeCarli M. Dick R. Duara D.A. Evans K.M. Faber K.B. Fallon D.W. Fardo M.R. Farlow S. Ferris T.M. Foroud D.R. Galasko M. Gearing D.H. Geschwind J.R. Gilbert N.R. Graff‐Radford R.C. Green J.H. Growdon R.L. Hamilton L.E. Harrell L.S. Honig M.J. Huentelman C.M. Hulette B.T. Hyman G.P. Jarvik E. Abner L.W. Jin G. Jun A. Karydas J.A. Kaye R. Kim N.W. Kowall J.H. Kramer F.M. LaFerla J.J. Lah J.B. Leverenz A.I. Levey G. Li A.P. Lieberman K.L. Lunetta C.G. Lyketsos D.C. Marson F. Martiniuk D.C. Mash E. Masliah W.C. McCormick S.M. McCurry A.N. McDavid A.C. McKee M. Mesulam B.L. Miller C.A. Miller J.W. Miller J.C. Morris J.R. Murrell A.J. Myers S. O'Bryant J.M. Olichney V.S. Pankratz J.E. Parisi H.L. Paulson W. Perry E. Peskind A. Pierce W.W. Poon H. Potter J.F. Quinn A. Raj M. Raskind B. Reisberg C. Reitz J.M. Ringman E.D. Roberson E. Rogaeva H.J. Rosen R.N. Rosenberg M.A. Sager A.J. Saykin J.A. Schneider L.S. Schneider W.W. Seeley A.G. Smith J.A. Sonnen S. Spina R.A. Stern R.H. Swerdlow R.E. Tanzi T.A. Thornton‐Wells J.Q. Trojanowski J.C. Troncoso V.M. Van Deerlin L.J. Van Eldik H.V. Vinters J.P. Vonsattel S. Weintraub K.A. Welsh‐Bohmer K.C. Wilhelmsen J. Williamson T.S. Wingo R.L. Woltjer C.B. Wright C.E. Yu L. Yu F. Garzia F. Golamaully G. Septier S. Engelborghs R. Vandenberghe P.P. De Deyn C.M. Fernadez Y.A. Benito H. Thonberg C. Forsell L. Lilius A. Kinhult‐Stählbom L. Kilander R. Brundin L. Concari S. Helisalmi A.M. Koivisto A. Haapasalo V. Dermecourt N. Fievet O. Hanon C. Dufouil A. Brice K. Ritchie B. Dubois J.J. Himali C.D. Keene J. Tschanz A.L. Fitzpatrick W.A. Kukull M. Norton T. Aspelund E.B. Larson R. Munger J.I. Rotter R.B. Lipton M.J. Bullido A. Hofman T.J. Montine E. Coto E. Boerwinkle R.C. Petersen V. Alvarez F. Rivadeneira E.M. Reiman M. Gallo C.J. O'Donnell J.S. Reisch A.C. Bruni D.R. Royall M. Dichgans M. Sano D. Galimberti P. St George‐Hyslop E. Scarpini D.W. Tsuang M. Mancuso U. Bonuccelli A.R. Winslow A. Daniele C.K. Wu GERAD/PERADES, CHARGE, ADGC, EADI O. Peters B. Nacmias M. Riemenschneider R. Heun C. Brayne D.C. Rubinsztein J. Bras R. Guerreiro A. Al‐Chalabi C.E. Shaw J. Collinge D. Mann M. Tsolaki J. Clarimón R. Sussams S. Lovestone M.C. O'Donovan M.J. Owen T.W. Behrens S. Mead A.M. Goate A.G. Uitterlinden C. Holmes C. Cruchaga M. Ingelsson D.A. Bennett J. Powell T.E. Golde C. Graff P.L. De Jager K. Morgan N. Ertekin‐Taner O. Combarros B.M. Psaty P. Passmore S.G. Younkin C. Berr V. Gudnason D. Rujescu D.W. Dickson J.F. Dartigues A.L. DeStefano S. Ortega‐Cubero H. Hakonarson D. Campion M. Boada J.K. Kauwe L.A. Farrer C. Van Broeckhoven M.A. Ikram L. Jones J.L. Haines C. Tzourio L.J. Launer V. Escott‐Price R. Mayeux J.F. Deleuze N. Amin P.A. Holmans M.A. Pericak‐Vance P. Amouyel C.M. vanDuijn A. Ramirez L.S. Wang J.C. Lambert S. Seshadri J. Williams G.D. Schellenberg Anita L. Destefano Sudha Seshardi |
spellingShingle |
Gina M. Peloso Sven J. van derLee International Genomics of Alzheimer's Project (IGAP) R. Sims S.J. van derLee A.C. Naj C. Bellenguez N. Badarinarayan J. Jakobsdottir B.W. Kunkle A. Boland R. Raybould J.C. Bis E.R. Martin B. Grenier‐Boley S. Heilmann‐Heimbach V. Chouraki A.B. Kuzma K. Sleegers M. Vronskaya A. Ruiz R.R. Graham R. Olaso P. Hoffmann M.L. Grove B.N. Vardarajan M. Hiltunen M.M. Nöthen C.C. White K.L. Hamilton‐Nelson J. Epelbaum W. Maier S.H. Choi G.W. Beecham C. Dulary S. Herms A.V. Smith C.C. Funk Derbois A.J. Forstner S. Ahmad H. Li D. Bacq D. Harold C.L. Satizabal O. Valladares A. Squassina R. Thomas J.A. Brody L. Qu P. Sánchez‐Juan T. Morgan F.J. Wolters Y. Zhao F.S. Garcia N. Denning M. Fornage J. Malamon M.C.D. Naranjo E. Majounie T.H. Mosley B. Dombroski D. Wallon M.K. Lupton J. Dupuis P. Whitehead L. Fratiglioni C. Medway X. Jian S. Mukherjee L. Keller K. Brown H. Lin L.B. Cantwell F. Panza B. McGuinness S. Moreno‐Grau J.D. Burgess V. Solfrizzi P. Proitsi H.H. Adams M. Allen D. Seripa P. Pastor L.A. Cupples N.D. Price D. Hannequin A. Frank‐García D. Levy P. Chakrabarty P. Caffarra I. Giegling A.S. Beiser V. Giedraitis H. Hampel M.E. Garcia X. Wang L. Lannfelt P. Mecocci G. Eiriksdottir P.K. Crane F. Pasquier V. Boccardi I. Henández R.C. Barber M. Scherer L. Tarraga P.M. Adams M. Leber Y. Chen M.S. Albert S. Riedel‐Heller V. Emilsson D. Beekly A. Braae R. Schmidt D. Blacker C. Masullo H. Schmidt R.S. Doody G. Spalletta W.T. Longstreth Jr. T.J. Fairchild P. Bossù O.L. Lopez M.P. Frosch E. Sacchinelli B. Ghetti Q. Yang R.M. Huebinger F. Jessen S. Li M.I. Kamboh J. Morris O. Sotolongo‐Grau M.J. Katz C. Corcoran M. Dunstan A. Braddel C. Thomas A. Meggy R. Marshall A. Gerrish J. Chapman M. Aguilar S. Taylor M. Hill M.D. Fairén A. Hodges B. Vellas H. Soininen I. Kloszewska M. Daniilidou J. Uphill Y. Patel J.T. Hughes J. Lord J. Turton A.M. Hartmann R. Cecchetti C. Fenoglio M. Serpente M. Arcaro C. Caltagirone M.D. Orfei A. Ciaramella S. Pichler M. Mayhaus W. Gu A. Lleó J. Fortea R. Blesa I.S. Barber K. Brookes C. Cupidi R.G. Maletta D. Carrell S. Sorbi S. Moebus M. Urbano A. Pilotto J. Kornhuber P. Bosco S. Todd D. Craig J. Johnston M. Gill B. Lawlor A. Lynch N.C. Fox J. Hardy ARUK Consortium R.L. Albin L.G. Apostolova S.E. Arnold S. Asthana C.S. Atwood C.T. Baldwin L.L. Barnes S. Barral T.G. Beach J.T. Becker E.H. Bigio T.D. Bird B.F. Boeve J.D. Bowen A. Boxer J.R. Burke J.M. Burns J.D. Buxbaum N.J. Cairns C. Cao C.S. Carlson C.M. Carlsson R.M. Carney M.M. Carrasquillo S.L. Carroll C.C. Diaz H.C. Chui D.G. Clark D.H. Cribbs E.A. Crocco C. DeCarli M. Dick R. Duara D.A. Evans K.M. Faber K.B. Fallon D.W. Fardo M.R. Farlow S. Ferris T.M. Foroud D.R. Galasko M. Gearing D.H. Geschwind J.R. Gilbert N.R. Graff‐Radford R.C. Green J.H. Growdon R.L. Hamilton L.E. Harrell L.S. Honig M.J. Huentelman C.M. Hulette B.T. Hyman G.P. Jarvik E. Abner L.W. Jin G. Jun A. Karydas J.A. Kaye R. Kim N.W. Kowall J.H. Kramer F.M. LaFerla J.J. Lah J.B. Leverenz A.I. Levey G. Li A.P. Lieberman K.L. Lunetta C.G. Lyketsos D.C. Marson F. Martiniuk D.C. Mash E. Masliah W.C. McCormick S.M. McCurry A.N. McDavid A.C. McKee M. Mesulam B.L. Miller C.A. Miller J.W. Miller J.C. Morris J.R. Murrell A.J. Myers S. O'Bryant J.M. Olichney V.S. Pankratz J.E. Parisi H.L. Paulson W. Perry E. Peskind A. Pierce W.W. Poon H. Potter J.F. Quinn A. Raj M. Raskind B. Reisberg C. Reitz J.M. Ringman E.D. Roberson E. Rogaeva H.J. Rosen R.N. Rosenberg M.A. Sager A.J. Saykin J.A. Schneider L.S. Schneider W.W. Seeley A.G. Smith J.A. Sonnen S. Spina R.A. Stern R.H. Swerdlow R.E. Tanzi T.A. Thornton‐Wells J.Q. Trojanowski J.C. Troncoso V.M. Van Deerlin L.J. Van Eldik H.V. Vinters J.P. Vonsattel S. Weintraub K.A. Welsh‐Bohmer K.C. Wilhelmsen J. Williamson T.S. Wingo R.L. Woltjer C.B. Wright C.E. Yu L. Yu F. Garzia F. Golamaully G. Septier S. Engelborghs R. Vandenberghe P.P. De Deyn C.M. Fernadez Y.A. Benito H. Thonberg C. Forsell L. Lilius A. Kinhult‐Stählbom L. Kilander R. Brundin L. Concari S. Helisalmi A.M. Koivisto A. Haapasalo V. Dermecourt N. Fievet O. Hanon C. Dufouil A. Brice K. Ritchie B. Dubois J.J. Himali C.D. Keene J. Tschanz A.L. Fitzpatrick W.A. Kukull M. Norton T. Aspelund E.B. Larson R. Munger J.I. Rotter R.B. Lipton M.J. Bullido A. Hofman T.J. Montine E. Coto E. Boerwinkle R.C. Petersen V. Alvarez F. Rivadeneira E.M. Reiman M. Gallo C.J. O'Donnell J.S. Reisch A.C. Bruni D.R. Royall M. Dichgans M. Sano D. Galimberti P. St George‐Hyslop E. Scarpini D.W. Tsuang M. Mancuso U. Bonuccelli A.R. Winslow A. Daniele C.K. Wu GERAD/PERADES, CHARGE, ADGC, EADI O. Peters B. Nacmias M. Riemenschneider R. Heun C. Brayne D.C. Rubinsztein J. Bras R. Guerreiro A. Al‐Chalabi C.E. Shaw J. Collinge D. Mann M. Tsolaki J. Clarimón R. Sussams S. Lovestone M.C. O'Donovan M.J. Owen T.W. Behrens S. Mead A.M. Goate A.G. Uitterlinden C. Holmes C. Cruchaga M. Ingelsson D.A. Bennett J. Powell T.E. Golde C. Graff P.L. De Jager K. Morgan N. Ertekin‐Taner O. Combarros B.M. Psaty P. Passmore S.G. Younkin C. Berr V. Gudnason D. Rujescu D.W. Dickson J.F. Dartigues A.L. DeStefano S. Ortega‐Cubero H. Hakonarson D. Campion M. Boada J.K. Kauwe L.A. Farrer C. Van Broeckhoven M.A. Ikram L. Jones J.L. Haines C. Tzourio L.J. Launer V. Escott‐Price R. Mayeux J.F. Deleuze N. Amin P.A. Holmans M.A. Pericak‐Vance P. Amouyel C.M. vanDuijn A. Ramirez L.S. Wang J.C. Lambert S. Seshadri J. Williams G.D. Schellenberg Anita L. Destefano Sudha Seshardi Genetically elevated high‐density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Genetics HDL‐C Single nucleotide polymorphisms Instrumental variables Cholesteryl ester transfer protein |
author_facet |
Gina M. Peloso Sven J. van derLee International Genomics of Alzheimer's Project (IGAP) R. Sims S.J. van derLee A.C. Naj C. Bellenguez N. Badarinarayan J. Jakobsdottir B.W. Kunkle A. Boland R. Raybould J.C. Bis E.R. Martin B. Grenier‐Boley S. Heilmann‐Heimbach V. Chouraki A.B. Kuzma K. Sleegers M. Vronskaya A. Ruiz R.R. Graham R. Olaso P. Hoffmann M.L. Grove B.N. Vardarajan M. Hiltunen M.M. Nöthen C.C. White K.L. Hamilton‐Nelson J. Epelbaum W. Maier S.H. Choi G.W. Beecham C. Dulary S. Herms A.V. Smith C.C. Funk Derbois A.J. Forstner S. Ahmad H. Li D. Bacq D. Harold C.L. Satizabal O. Valladares A. Squassina R. Thomas J.A. Brody L. Qu P. Sánchez‐Juan T. Morgan F.J. Wolters Y. Zhao F.S. Garcia N. Denning M. Fornage J. Malamon M.C.D. Naranjo E. Majounie T.H. Mosley B. Dombroski D. Wallon M.K. Lupton J. Dupuis P. Whitehead L. Fratiglioni C. Medway X. Jian S. Mukherjee L. Keller K. Brown H. Lin L.B. Cantwell F. Panza B. McGuinness S. Moreno‐Grau J.D. Burgess V. Solfrizzi P. Proitsi H.H. Adams M. Allen D. Seripa P. Pastor L.A. Cupples N.D. Price D. Hannequin A. Frank‐García D. Levy P. Chakrabarty P. Caffarra I. Giegling A.S. Beiser V. Giedraitis H. Hampel M.E. Garcia X. Wang L. Lannfelt P. Mecocci G. Eiriksdottir P.K. Crane F. Pasquier V. Boccardi I. Henández R.C. Barber M. Scherer L. Tarraga P.M. Adams M. Leber Y. Chen M.S. Albert S. Riedel‐Heller V. Emilsson D. Beekly A. Braae R. Schmidt D. Blacker C. Masullo H. Schmidt R.S. Doody G. Spalletta W.T. Longstreth Jr. T.J. Fairchild P. Bossù O.L. Lopez M.P. Frosch E. Sacchinelli B. Ghetti Q. Yang R.M. Huebinger F. Jessen S. Li M.I. Kamboh J. Morris O. Sotolongo‐Grau M.J. Katz C. Corcoran M. Dunstan A. Braddel C. Thomas A. Meggy R. Marshall A. Gerrish J. Chapman M. Aguilar S. Taylor M. Hill M.D. Fairén A. Hodges B. Vellas H. Soininen I. Kloszewska M. Daniilidou J. Uphill Y. Patel J.T. Hughes J. Lord J. Turton A.M. Hartmann R. Cecchetti C. Fenoglio M. Serpente M. Arcaro C. Caltagirone M.D. Orfei A. Ciaramella S. Pichler M. Mayhaus W. Gu A. Lleó J. Fortea R. Blesa I.S. Barber K. Brookes C. Cupidi R.G. Maletta D. Carrell S. Sorbi S. Moebus M. Urbano A. Pilotto J. Kornhuber P. Bosco S. Todd D. Craig J. Johnston M. Gill B. Lawlor A. Lynch N.C. Fox J. Hardy ARUK Consortium R.L. Albin L.G. Apostolova S.E. Arnold S. Asthana C.S. Atwood C.T. Baldwin L.L. Barnes S. Barral T.G. Beach J.T. Becker E.H. Bigio T.D. Bird B.F. Boeve J.D. Bowen A. Boxer J.R. Burke J.M. Burns J.D. Buxbaum N.J. Cairns C. Cao C.S. Carlson C.M. Carlsson R.M. Carney M.M. Carrasquillo S.L. Carroll C.C. Diaz H.C. Chui D.G. Clark D.H. Cribbs E.A. Crocco C. DeCarli M. Dick R. Duara D.A. Evans K.M. Faber K.B. Fallon D.W. Fardo M.R. Farlow S. Ferris T.M. Foroud D.R. Galasko M. Gearing D.H. Geschwind J.R. Gilbert N.R. Graff‐Radford R.C. Green J.H. Growdon R.L. Hamilton L.E. Harrell L.S. Honig M.J. Huentelman C.M. Hulette B.T. Hyman G.P. Jarvik E. Abner L.W. Jin G. Jun A. Karydas J.A. Kaye R. Kim N.W. Kowall J.H. Kramer F.M. LaFerla J.J. Lah J.B. Leverenz A.I. Levey G. Li A.P. Lieberman K.L. Lunetta C.G. Lyketsos D.C. Marson F. Martiniuk D.C. Mash E. Masliah W.C. McCormick S.M. McCurry A.N. McDavid A.C. McKee M. Mesulam B.L. Miller C.A. Miller J.W. Miller J.C. Morris J.R. Murrell A.J. Myers S. O'Bryant J.M. Olichney V.S. Pankratz J.E. Parisi H.L. Paulson W. Perry E. Peskind A. Pierce W.W. Poon H. Potter J.F. Quinn A. Raj M. Raskind B. Reisberg C. Reitz J.M. Ringman E.D. Roberson E. Rogaeva H.J. Rosen R.N. Rosenberg M.A. Sager A.J. Saykin J.A. Schneider L.S. Schneider W.W. Seeley A.G. Smith J.A. Sonnen S. Spina R.A. Stern R.H. Swerdlow R.E. Tanzi T.A. Thornton‐Wells J.Q. Trojanowski J.C. Troncoso V.M. Van Deerlin L.J. Van Eldik H.V. Vinters J.P. Vonsattel S. Weintraub K.A. Welsh‐Bohmer K.C. Wilhelmsen J. Williamson T.S. Wingo R.L. Woltjer C.B. Wright C.E. Yu L. Yu F. Garzia F. Golamaully G. Septier S. Engelborghs R. Vandenberghe P.P. De Deyn C.M. Fernadez Y.A. Benito H. Thonberg C. Forsell L. Lilius A. Kinhult‐Stählbom L. Kilander R. Brundin L. Concari S. Helisalmi A.M. Koivisto A. Haapasalo V. Dermecourt N. Fievet O. Hanon C. Dufouil A. Brice K. Ritchie B. Dubois J.J. Himali C.D. Keene J. Tschanz A.L. Fitzpatrick W.A. Kukull M. Norton T. Aspelund E.B. Larson R. Munger J.I. Rotter R.B. Lipton M.J. Bullido A. Hofman T.J. Montine E. Coto E. Boerwinkle R.C. Petersen V. Alvarez F. Rivadeneira E.M. Reiman M. Gallo C.J. O'Donnell J.S. Reisch A.C. Bruni D.R. Royall M. Dichgans M. Sano D. Galimberti P. St George‐Hyslop E. Scarpini D.W. Tsuang M. Mancuso U. Bonuccelli A.R. Winslow A. Daniele C.K. Wu GERAD/PERADES, CHARGE, ADGC, EADI O. Peters B. Nacmias M. Riemenschneider R. Heun C. Brayne D.C. Rubinsztein J. Bras R. Guerreiro A. Al‐Chalabi C.E. Shaw J. Collinge D. Mann M. Tsolaki J. Clarimón R. Sussams S. Lovestone M.C. O'Donovan M.J. Owen T.W. Behrens S. Mead A.M. Goate A.G. Uitterlinden C. Holmes C. Cruchaga M. Ingelsson D.A. Bennett J. Powell T.E. Golde C. Graff P.L. De Jager K. Morgan N. Ertekin‐Taner O. Combarros B.M. Psaty P. Passmore S.G. Younkin C. Berr V. Gudnason D. Rujescu D.W. Dickson J.F. Dartigues A.L. DeStefano S. Ortega‐Cubero H. Hakonarson D. Campion M. Boada J.K. Kauwe L.A. Farrer C. Van Broeckhoven M.A. Ikram L. Jones J.L. Haines C. Tzourio L.J. Launer V. Escott‐Price R. Mayeux J.F. Deleuze N. Amin P.A. Holmans M.A. Pericak‐Vance P. Amouyel C.M. vanDuijn A. Ramirez L.S. Wang J.C. Lambert S. Seshadri J. Williams G.D. Schellenberg Anita L. Destefano Sudha Seshardi |
author_sort |
Gina M. Peloso |
title |
Genetically elevated high‐density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease |
title_short |
Genetically elevated high‐density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease |
title_full |
Genetically elevated high‐density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease |
title_fullStr |
Genetically elevated high‐density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease |
title_full_unstemmed |
Genetically elevated high‐density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease |
title_sort |
genetically elevated high‐density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of alzheimer's disease |
publisher |
Wiley |
series |
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
issn |
2352-8729 |
publishDate |
2018-01-01 |
description |
Abstract Introduction There is conflicting evidence whether high‐density lipoprotein cholesterol (HDL‐C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (CETP) locus is associated with altered HDL‐C. We aimed to assess AD risk by genetically predicted HDL‐C. Methods Ten single nucleotide polymorphisms within the CETP locus predicting HDL‐C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. We performed instrumental variables analysis using inverse variance weighting, weighted median, and MR‐Egger. Results Based on 10 single nucleotide polymorphisms distinctly predicting HDL‐C in the CETP locus, we found that HDL‐C was not associated with risk of AD (P > .7). Discussion Our study does not support the role of HDL‐C on risk of AD through HDL‐C altered by CETP. This study does not rule out other mechanisms by which HDL‐C affects risk of AD. |
topic |
Genetics HDL‐C Single nucleotide polymorphisms Instrumental variables Cholesteryl ester transfer protein |
url |
https://doi.org/10.1016/j.dadm.2018.08.008 |
work_keys_str_mv |
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geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ccaltagirone geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mdorfei geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT aciaramella geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT spichler geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mmayhaus geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT wgu geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT alleo geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jfortea geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rblesa geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT isbarber geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT kbrookes geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ccupidi geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rgmaletta geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT dcarrell geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ssorbi geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT smoebus geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT murbano geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT apilotto geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jkornhuber geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT pbosco geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT stodd geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT dcraig geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jjohnston geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mgill geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT blawlor geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT alynch geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ncfox geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jhardy geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT arukconsortium geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rlalbin geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT lgapostolova geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT searnold geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT sasthana geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT csatwood geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ctbaldwin geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT llbarnes geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT sbarral geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT tgbeach geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jtbecker geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ehbigio geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT tdbird geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT bfboeve geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jdbowen geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT aboxer geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jrburke geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jmburns geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jdbuxbaum geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT njcairns geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ccao geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT cscarlson geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT cmcarlsson geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rmcarney geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mmcarrasquillo geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT slcarroll geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ccdiaz geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT hcchui geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT dgclark geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT dhcribbs geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT eacrocco geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT cdecarli geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mdick geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rduara geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT daevans geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT kmfaber geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT kbfallon geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT dwfardo geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mrfarlow geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT sferris geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT tmforoud geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT drgalasko geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mgearing geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT dhgeschwind geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jrgilbert geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT nrgraffradford geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rcgreen geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jhgrowdon geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rlhamilton geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT leharrell geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT lshonig geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mjhuentelman geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT cmhulette geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT bthyman geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT gpjarvik geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT eabner geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT lwjin geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT gjun geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT akarydas geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jakaye geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rkim geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT nwkowall geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jhkramer geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT fmlaferla geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jjlah geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jbleverenz geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ailevey geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT gli geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT aplieberman geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT kllunetta geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT cglyketsos geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT dcmarson geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT fmartiniuk geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT dcmash geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT emasliah geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT wcmccormick geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT smmccurry geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT anmcdavid geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT acmckee geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mmesulam geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT blmiller geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT camiller geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jwmiller geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jcmorris geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jrmurrell geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ajmyers geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT sobryant geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jmolichney geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT vspankratz geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jeparisi geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT hlpaulson geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT wperry geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT epeskind geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT apierce geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT wwpoon geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT hpotter geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jfquinn geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT araj geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mraskind geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT breisberg geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT creitz geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jmringman geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT edroberson geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT erogaeva geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT hjrosen geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rnrosenberg geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT masager geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ajsaykin geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jaschneider geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT lsschneider geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT wwseeley geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT agsmith geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jasonnen geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT sspina geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rastern geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rhswerdlow geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT retanzi geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT tathorntonwells geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jqtrojanowski geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jctroncoso geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT vmvandeerlin geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ljvaneldik geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT hvvinters geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jpvonsattel geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT sweintraub geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT kawelshbohmer geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT kcwilhelmsen geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jwilliamson geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT tswingo geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rlwoltjer geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT cbwright geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ceyu geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT lyu geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT fgarzia geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT fgolamaully geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT gseptier geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT sengelborghs geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rvandenberghe geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ppdedeyn geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT cmfernadez geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT yabenito geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT hthonberg geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT cforsell geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT llilius geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT akinhultstahlbom geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT lkilander geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rbrundin geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT lconcari geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT shelisalmi geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT amkoivisto geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ahaapasalo geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT vdermecourt geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT nfievet geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ohanon geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT cdufouil geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT abrice geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT kritchie geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT bdubois geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jjhimali geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT cdkeene geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jtschanz geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT alfitzpatrick geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT wakukull geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mnorton geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT taspelund geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT eblarson geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rmunger geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jirotter geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rblipton geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mjbullido geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ahofman geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT tjmontine geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ecoto geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT eboerwinkle geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rcpetersen geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT valvarez geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT frivadeneira geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT emreiman geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mgallo geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT cjodonnell geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jsreisch geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT acbruni geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT drroyall geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mdichgans geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT msano geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT dgalimberti geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT pstgeorgehyslop geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT escarpini geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT dwtsuang geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mmancuso geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ubonuccelli geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT arwinslow geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT adaniele geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ckwu geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT geradperadeschargeadgceadi geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT opeters geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT bnacmias geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mriemenschneider geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rheun geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT cbrayne geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT dcrubinsztein geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jbras geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rguerreiro geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT aalchalabi geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ceshaw geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jcollinge geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT dmann geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mtsolaki geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jclarimon geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rsussams geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT slovestone geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mcodonovan geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mjowen geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT twbehrens geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT smead geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT amgoate geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT aguitterlinden geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT cholmes geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ccruchaga geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mingelsson geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT dabennett geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jpowell geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT tegolde geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT cgraff geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT pldejager geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT kmorgan geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT nertekintaner geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ocombarros geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT bmpsaty geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ppassmore geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT sgyounkin geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT cberr geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT vgudnason geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT drujescu geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT dwdickson geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jfdartigues geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT aldestefano geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT sortegacubero geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT hhakonarson geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT dcampion geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mboada geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jkkauwe geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT lafarrer geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT cvanbroeckhoven geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT maikram geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ljones geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jlhaines geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ctzourio geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT ljlauner geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT vescottprice geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT rmayeux geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jfdeleuze geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT namin geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT paholmans geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT mapericakvance geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT pamouyel geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT cmvanduijn geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT aramirez geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT lswang geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jclambert geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT sseshadri geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT jwilliams geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT gdschellenberg geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT anitaldestefano geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease AT sudhaseshardi geneticallyelevatedhighdensitylipoproteincholesterolthroughthecholesterylestertransferproteingenedoesnotassociatewithriskofalzheimersdisease |
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doaj-accd30591f1c42d8a1e20fc987ef9a6d2020-11-25T03:38:46ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292018-01-0110159559810.1016/j.dadm.2018.08.008Genetically elevated high‐density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's diseaseGina M. Peloso0Sven J. van derLee1International Genomics of Alzheimer's Project (IGAP)R. Sims2S.J. van derLee3A.C. Naj4C. Bellenguez5N. Badarinarayan6J. Jakobsdottir7B.W. Kunkle8A. Boland9R. Raybould10J.C. Bis11E.R. Martin12B. Grenier‐Boley13S. Heilmann‐Heimbach14V. Chouraki15A.B. Kuzma16K. Sleegers17M. Vronskaya18A. Ruiz19R.R. Graham20R. Olaso21P. Hoffmann22M.L. Grove23B.N. Vardarajan24M. Hiltunen25M.M. Nöthen26C.C. White27K.L. Hamilton‐Nelson28J. Epelbaum29W. Maier30S.H. Choi31G.W. Beecham32C. Dulary33S. Herms34A.V. Smith35C.C. Funk36Derbois37A.J. Forstner38S. Ahmad39H. Li40D. Bacq41D. Harold42C.L. Satizabal43O. Valladares44A. Squassina45R. Thomas46J.A. Brody47L. Qu48P. Sánchez‐Juan49T. Morgan50F.J. Wolters51Y. Zhao52F.S. Garcia53N. Denning54M. Fornage55J. Malamon56M.C.D. Naranjo57E. Majounie58T.H. Mosley59B. Dombroski60D. Wallon61M.K. Lupton62J. Dupuis63P. Whitehead64L. Fratiglioni65C. Medway66X. Jian67S. Mukherjee68L. Keller69K. Brown70H. Lin71L.B. Cantwell72F. Panza73B. McGuinness74S. Moreno‐Grau75J.D. Burgess76V. Solfrizzi77P. Proitsi78H.H. Adams79M. Allen80D. Seripa81P. Pastor82L.A. Cupples83N.D. Price84D. Hannequin85A. Frank‐García86D. Levy87P. Chakrabarty88P. Caffarra89I. Giegling90A.S. Beiser91V. Giedraitis92H. Hampel93M.E. Garcia94X. Wang95L. Lannfelt96P. Mecocci97G. Eiriksdottir98P.K. Crane99F. Pasquier100V. Boccardi101I. Henández102R.C. Barber103M. Scherer104L. Tarraga105P.M. Adams106M. Leber107Y. Chen108M.S. Albert109S. Riedel‐Heller110V. Emilsson111D. Beekly112A. Braae113R. Schmidt114D. Blacker115C. Masullo116H. Schmidt117R.S. Doody118G. Spalletta119W.T. Longstreth Jr.120T.J. Fairchild121P. Bossù122O.L. Lopez123M.P. Frosch124E. Sacchinelli125B. Ghetti126Q. Yang127R.M. Huebinger128F. Jessen129S. Li130M.I. Kamboh131J. Morris132O. Sotolongo‐Grau133M.J. Katz134C. Corcoran135M. Dunstan136A. Braddel137C. Thomas138A. Meggy139R. Marshall140A. Gerrish141J. Chapman142M. Aguilar143S. Taylor144M. Hill145M.D. Fairén146A. Hodges147B. Vellas148H. Soininen149I. Kloszewska150M. Daniilidou151J. Uphill152Y. Patel153J.T. Hughes154J. Lord155J. Turton156A.M. Hartmann157R. Cecchetti158C. Fenoglio159M. Serpente160M. Arcaro161C. Caltagirone162M.D. Orfei163A. Ciaramella164S. Pichler165M. Mayhaus166W. Gu167A. Lleó168J. Fortea169R. Blesa170I.S. Barber171K. Brookes172C. Cupidi173R.G. Maletta174D. Carrell175S. Sorbi176S. Moebus177M. Urbano178A. Pilotto179J. Kornhuber180P. Bosco181S. Todd182D. Craig183J. Johnston184M. Gill185B. Lawlor186A. Lynch187N.C. Fox188J. Hardy189ARUK Consortium190R.L. Albin191L.G. Apostolova192S.E. Arnold193S. Asthana194C.S. Atwood195C.T. Baldwin196L.L. Barnes197S. Barral198T.G. Beach199J.T. Becker200E.H. Bigio201T.D. Bird202B.F. Boeve203J.D. Bowen204A. Boxer205J.R. Burke206J.M. Burns207J.D. Buxbaum208N.J. Cairns209C. Cao210C.S. Carlson211C.M. Carlsson212R.M. Carney213M.M. Carrasquillo214S.L. Carroll215C.C. Diaz216H.C. Chui217D.G. Clark218D.H. Cribbs219E.A. Crocco220C. DeCarli221M. Dick222R. Duara223D.A. Evans224K.M. Faber225K.B. Fallon226D.W. Fardo227M.R. Farlow228S. Ferris229T.M. Foroud230D.R. Galasko231M. Gearing232D.H. Geschwind233J.R. Gilbert234N.R. Graff‐Radford235R.C. Green236J.H. Growdon237R.L. Hamilton238L.E. Harrell239L.S. Honig240M.J. Huentelman241C.M. Hulette242B.T. Hyman243G.P. Jarvik244E. Abner245L.W. Jin246G. Jun247A. Karydas248J.A. Kaye249R. Kim250N.W. Kowall251J.H. Kramer252F.M. LaFerla253J.J. Lah254J.B. Leverenz255A.I. Levey256G. Li257A.P. Lieberman258K.L. Lunetta259C.G. Lyketsos260D.C. Marson261F. Martiniuk262D.C. Mash263E. Masliah264W.C. McCormick265S.M. McCurry266A.N. McDavid267A.C. McKee268M. Mesulam269B.L. Miller270C.A. Miller271J.W. Miller272J.C. Morris273J.R. Murrell274A.J. Myers275S. O'Bryant276J.M. Olichney277V.S. Pankratz278J.E. Parisi279H.L. Paulson280W. Perry281E. Peskind282A. Pierce283W.W. Poon284H. Potter285J.F. Quinn286A. Raj287M. Raskind288B. Reisberg289C. Reitz290J.M. Ringman291E.D. Roberson292E. Rogaeva293H.J. Rosen294R.N. Rosenberg295M.A. Sager296A.J. Saykin297J.A. Schneider298L.S. Schneider299W.W. Seeley300A.G. Smith301J.A. Sonnen302S. Spina303R.A. Stern304R.H. Swerdlow305R.E. Tanzi306T.A. Thornton‐Wells307J.Q. Trojanowski308J.C. Troncoso309V.M. Van Deerlin310L.J. Van Eldik311H.V. Vinters312J.P. Vonsattel313S. Weintraub314K.A. Welsh‐Bohmer315K.C. Wilhelmsen316J. Williamson317T.S. Wingo318R.L. Woltjer319C.B. Wright320C.E. Yu321L. Yu322F. Garzia323F. Golamaully324G. Septier325S. Engelborghs326R. Vandenberghe327P.P. De Deyn328C.M. Fernadez329Y.A. Benito330H. Thonberg331C. Forsell332L. Lilius333A. Kinhult‐Stählbom334L. Kilander335R. Brundin336L. Concari337S. Helisalmi338A.M. Koivisto339A. Haapasalo340V. Dermecourt341N. Fievet342O. Hanon343C. Dufouil344A. Brice345K. Ritchie346B. Dubois347J.J. Himali348C.D. Keene349J. Tschanz350A.L. Fitzpatrick351W.A. Kukull352M. Norton353T. Aspelund354E.B. Larson355R. Munger356J.I. Rotter357R.B. Lipton358M.J. Bullido359A. Hofman360T.J. Montine361E. Coto362E. Boerwinkle363R.C. Petersen364V. Alvarez365F. Rivadeneira366E.M. Reiman367M. Gallo368C.J. O'Donnell369J.S. Reisch370A.C. Bruni371D.R. Royall372M. Dichgans373M. Sano374D. Galimberti375P. St George‐Hyslop376E. Scarpini377D.W. Tsuang378M. Mancuso379U. Bonuccelli380A.R. Winslow381A. Daniele382C.K. Wu383GERAD/PERADES, CHARGE, ADGC, EADI384O. Peters385B. Nacmias386M. Riemenschneider387R. Heun388C. Brayne389D.C. Rubinsztein390J. Bras391R. Guerreiro392A. Al‐Chalabi393C.E. Shaw394J. Collinge395D. Mann396M. Tsolaki397J. Clarimón398R. Sussams399S. Lovestone400M.C. O'Donovan401M.J. Owen402T.W. Behrens403S. Mead404A.M. Goate405A.G. Uitterlinden406C. Holmes407C. Cruchaga408M. Ingelsson409D.A. Bennett410J. Powell411T.E. Golde412C. Graff413P.L. De Jager414K. Morgan415N. Ertekin‐Taner416O. Combarros417B.M. Psaty418P. Passmore419S.G. Younkin420C. Berr421V. Gudnason422D. Rujescu423D.W. Dickson424J.F. Dartigues425A.L. DeStefano426S. Ortega‐Cubero427H. Hakonarson428D. Campion429M. Boada430J.K. Kauwe431L.A. Farrer432C. Van Broeckhoven433M.A. Ikram434L. Jones435J.L. Haines436C. Tzourio437L.J. Launer438V. Escott‐Price439R. Mayeux440J.F. Deleuze441N. Amin442P.A. Holmans443M.A. Pericak‐Vance444P. Amouyel445C.M. vanDuijn446A. Ramirez447L.S. Wang448J.C. Lambert449S. Seshadri450J. Williams451G.D. Schellenberg452Anita L. Destefano453Sudha Seshardi454Department of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSADepartment of BiostatisticsBoston University School of Public HealthBostonMAUSAAbstract Introduction There is conflicting evidence whether high‐density lipoprotein cholesterol (HDL‐C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (CETP) locus is associated with altered HDL‐C. We aimed to assess AD risk by genetically predicted HDL‐C. Methods Ten single nucleotide polymorphisms within the CETP locus predicting HDL‐C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. We performed instrumental variables analysis using inverse variance weighting, weighted median, and MR‐Egger. Results Based on 10 single nucleotide polymorphisms distinctly predicting HDL‐C in the CETP locus, we found that HDL‐C was not associated with risk of AD (P > .7). Discussion Our study does not support the role of HDL‐C on risk of AD through HDL‐C altered by CETP. This study does not rule out other mechanisms by which HDL‐C affects risk of AD.https://doi.org/10.1016/j.dadm.2018.08.008GeneticsHDL‐CSingle nucleotide polymorphismsInstrumental variablesCholesteryl ester transfer protein |