Th9 Cell Differentiation and Its Dual Effects in Tumor Development
With the improved understanding of the molecular pathogenesis and characteristics of cancers, the critical role of the immune system in preventing tumor development has been widely accepted. The understanding of the relationship between the immune system and cancer progression is constantly evolving...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2020-05-01
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Series: | Frontiers in Immunology |
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Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01026/full |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tao Chen Tao Chen Jufeng Guo Zhenhai Cai Binghao Li Binghao Li Lingling Sun Lingling Sun Yingying Shen Shengdong Wang Shengdong Wang Zhan Wang Zhan Wang Zenan Wang Zenan Wang Yucheng Wang Yucheng Wang Hao Zhou Hao Zhou Zhijian Cai Zhijian Cai Zhijian Cai Zhaoming Ye Zhaoming Ye |
spellingShingle |
Tao Chen Tao Chen Jufeng Guo Zhenhai Cai Binghao Li Binghao Li Lingling Sun Lingling Sun Yingying Shen Shengdong Wang Shengdong Wang Zhan Wang Zhan Wang Zenan Wang Zenan Wang Yucheng Wang Yucheng Wang Hao Zhou Hao Zhou Zhijian Cai Zhijian Cai Zhijian Cai Zhaoming Ye Zhaoming Ye Th9 Cell Differentiation and Its Dual Effects in Tumor Development Frontiers in Immunology Th9 cells IL-9 cancer cancer immunotherapy adoptive cell therapy regulation of CD4 helper T cell differentiation |
author_facet |
Tao Chen Tao Chen Jufeng Guo Zhenhai Cai Binghao Li Binghao Li Lingling Sun Lingling Sun Yingying Shen Shengdong Wang Shengdong Wang Zhan Wang Zhan Wang Zenan Wang Zenan Wang Yucheng Wang Yucheng Wang Hao Zhou Hao Zhou Zhijian Cai Zhijian Cai Zhijian Cai Zhaoming Ye Zhaoming Ye |
author_sort |
Tao Chen |
title |
Th9 Cell Differentiation and Its Dual Effects in Tumor Development |
title_short |
Th9 Cell Differentiation and Its Dual Effects in Tumor Development |
title_full |
Th9 Cell Differentiation and Its Dual Effects in Tumor Development |
title_fullStr |
Th9 Cell Differentiation and Its Dual Effects in Tumor Development |
title_full_unstemmed |
Th9 Cell Differentiation and Its Dual Effects in Tumor Development |
title_sort |
th9 cell differentiation and its dual effects in tumor development |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2020-05-01 |
description |
With the improved understanding of the molecular pathogenesis and characteristics of cancers, the critical role of the immune system in preventing tumor development has been widely accepted. The understanding of the relationship between the immune system and cancer progression is constantly evolving, from the cancer immunosurveillance hypothesis to immunoediting theory and the delicate balance in the tumor microenvironment. Currently, immunotherapy is regarded as a promising strategy against cancers. Although adoptive cell therapy (ACT) has shown some exciting results regarding the rejection of tumors, the effect is not always satisfactory. Cellular therapy with CD4+ T cells remains to be further explored since the current ACT is mainly focused on CD8+ cytotoxic T lymphocytes (CTLs). Recently, Th9 cells, a subgroup of CD4+ T helper cells characterized by the secretion of IL-9 and IL-10, have been reported to be effective in the elimination of solid tumors and to exhibit superior antitumor properties to Th1 and Th17 cells. In this review, we summarize the most recent advances in the understanding of Th9 cell differentiation and the dual role, both anti-tumor and pro-tumor effects, of Th9 cells in tumor progression. |
topic |
Th9 cells IL-9 cancer cancer immunotherapy adoptive cell therapy regulation of CD4 helper T cell differentiation |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2020.01026/full |
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doaj-accf1f9f6666481695ae0e9146fa79e72020-11-25T03:36:34ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-05-011110.3389/fimmu.2020.01026539666Th9 Cell Differentiation and Its Dual Effects in Tumor DevelopmentTao Chen0Tao Chen1Jufeng Guo2Zhenhai Cai3Binghao Li4Binghao Li5Lingling Sun6Lingling Sun7Yingying Shen8Shengdong Wang9Shengdong Wang10Zhan Wang11Zhan Wang12Zenan Wang13Zenan Wang14Yucheng Wang15Yucheng Wang16Hao Zhou17Hao Zhou18Zhijian Cai19Zhijian Cai20Zhijian Cai21Zhaoming Ye22Zhaoming Ye23Department of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaInstitute of Orthopedic Research, Zhejiang University, Hangzhou, ChinaDepartment of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Orthopedics Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing, ChinaDepartment of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaInstitute of Orthopedic Research, Zhejiang University, Hangzhou, ChinaDepartment of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaInstitute of Orthopedic Research, Zhejiang University, Hangzhou, ChinaInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaInstitute of Orthopedic Research, Zhejiang University, Hangzhou, ChinaDepartment of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaInstitute of Orthopedic Research, Zhejiang University, Hangzhou, ChinaDepartment of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaInstitute of Orthopedic Research, Zhejiang University, Hangzhou, ChinaDepartment of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaInstitute of Orthopedic Research, Zhejiang University, Hangzhou, ChinaDepartment of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaInstitute of Orthopedic Research, Zhejiang University, Hangzhou, ChinaDepartment of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaInstitute of Orthopedic Research, Zhejiang University, Hangzhou, ChinaInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaInstitute of Orthopedic Research, Zhejiang University, Hangzhou, ChinaWith the improved understanding of the molecular pathogenesis and characteristics of cancers, the critical role of the immune system in preventing tumor development has been widely accepted. The understanding of the relationship between the immune system and cancer progression is constantly evolving, from the cancer immunosurveillance hypothesis to immunoediting theory and the delicate balance in the tumor microenvironment. Currently, immunotherapy is regarded as a promising strategy against cancers. Although adoptive cell therapy (ACT) has shown some exciting results regarding the rejection of tumors, the effect is not always satisfactory. Cellular therapy with CD4+ T cells remains to be further explored since the current ACT is mainly focused on CD8+ cytotoxic T lymphocytes (CTLs). Recently, Th9 cells, a subgroup of CD4+ T helper cells characterized by the secretion of IL-9 and IL-10, have been reported to be effective in the elimination of solid tumors and to exhibit superior antitumor properties to Th1 and Th17 cells. In this review, we summarize the most recent advances in the understanding of Th9 cell differentiation and the dual role, both anti-tumor and pro-tumor effects, of Th9 cells in tumor progression.https://www.frontiersin.org/article/10.3389/fimmu.2020.01026/fullTh9 cellsIL-9cancercancer immunotherapyadoptive cell therapyregulation of CD4 helper T cell differentiation |