Obesity promotes gastric cancer metastasis via diacylglycerol acyltransferase 2-dependent lipid droplets accumulation and redox homeostasis

Obesity promotes gastric cancer metastasis via diacylglycerol acyltransferase 2-dependent lipid droplets accumulation and redox homeostasis

Experimental and molecular epidemiological studies indicate important roles for adipose tissue or high-fat diet (HFD) in tumor growth and metastasis. Gastric cancer (GC) possesses a metastatic predilection for the adipocyte-rich peritoneum. However, the precise molecular relevance of HFD in the peri...

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Bibliographic Details
Main Authors:	Shuai Li, Teng Wu, Yun-Xin Lu, Jin-Xiang Wang, Feng-Hai Yu, Mei-Zhu Yang, Yi-Jia Huang, Zhi-Jing Li, Sen-Lan Wang, Ling Huang, Lei Lu, Tian Tian
Format:	Article
Language:	English
Published:	Elsevier 2020-09-01
Series:	Redox Biology
Subjects:	DGAT2 Gastric cancer Lipid droplets Anoikis resistance NADPH
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231720303268

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