CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase

CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase

Mutations in human CGI-58/ABHD5 cause Chanarin-Dorfman syndrome (CDS), characterized by excessive storage of triacylglycerol in tissues. CGI-58 is an α/β-hydrolase fold enzyme expressed in all vertebrates. The carboxyl terminus includes a highly conserved consensus sequence (HXXXXD) for acyltransfer...

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Bibliographic Details
Main Authors: Gabriela Montero-Moran, Jorge M. Caviglia, Derek McMahon, Alexis Rothenberg, Vidya Subramanian, Zhi Xu, Samuel Lara-Gonzalez, Judith Storch, George M. Carman, Dawn L. Brasaemle
Format: Article
Language:English
Published: Elsevier 2010-04-01
Series:Journal of Lipid Research
Subjects:
Chanarin-Dorfman Syndrome
neutral lipid storage disorder
α/β-hydrolase fold enzymes
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520304818

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http://www.sciencedirect.com/science/article/pii/S0022227520304818

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